Q13133 | NR1H3_HUMAN | Oxysterols receptor LXR-alpha (NR1H3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00104 | Hormone_recep - Ligand-binding domain of nuclear hormone receptor | 252~430 | |
| PF00105 | zf-C4 - Double treble clef zinc finger, C4 type | 97~164 |
3D structures mapped by conservation among orthologs
[ Domain: "Nuclear receptor ligand-binding domain" // Hormone_recep ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL595012 |  |
IC50 | = | 0.8 | nM | 488.53 | CC(C)Cc1nc2c(C(F)(F)F)cccc2n1-c1cccc(Oc2cccc(S(C)(=O)=O)c2)c1 | Homo sapiens | CHEMBL1069926 | single protein format |
| CHEMBL611735 |  |
IC50 | = | 0.81 | nM | 522.55 | CS(=O)(=O)c1cccc(Oc2cccc(-c3c(Cc4ccccc4)nc4c(C(F)(F)F)cccn34)c2)c1 | Homo sapiens | CHEMBL1071219 | single protein format |
| CHEMBL592506 |  |
IC50 | = | 0.92 | nM | 533.57 | CS(=O)(=O)c1cccc(Oc2cccc(-c3c(Cc4ccccc4)cnc4c(C(F)(F)F)cccc34)c2)c1 | Homo sapiens | CHEMBL1047697 | single protein format |
| CHEMBL603636 |  |
IC50 | = | 1.0 | nM | 474.5 | CC(C)c1nc2c(C(F)(F)F)cccc2n1-c1cccc(Oc2cccc(S(C)(=O)=O)c2)c1 | Homo sapiens | CHEMBL1069926 | single protein format |
| CHEMBL365544 |  |
IC50 | = | 1.0 | nM | 529.72 | CC1(C(=O)NC(=O)[C@@]2(C)CCC[C@]3(C)c4cc(O)ccc4CC[C@@H]23)CCC[C@]2(C)c3cc(O)ccc3CC[C@@H]12 | Homo sapiens | CHEMBL828112 | assay format |
| CHEMBL384246 |  |
IC50 | = | 1.0 | nM | 465.74 | OC(c1ccc(N(Cc2ccccc2)CC(F)(F)F)c(Cl)c1)(C(F)(F)F)C(F)(F)F | Homo sapiens | CHEMBL912135 | single protein format |
| CHEMBL595689 |  |
IC50 | = | 1.0 | nM | 457.47 | Cc1cnc2c(C(F)(F)F)cccc2c1-c1cccc(Oc2cccc(S(C)(=O)=O)c2)c1 | Homo sapiens | CHEMBL1069926 | single protein format |
| CHEMBL595224 |  |
IC50 | = | 1.1 | nM | 508.52 | CS(=O)(=O)c1cccc(Oc2cccc(-n3c(-c4ccccc4)nc4c(C(F)(F)F)cccc43)c2)c1 | Homo sapiens | CHEMBL1069926 | single protein format |
| CHEMBL595782 |  |
IC50 | = | 1.1 | nM | 423.92 | Cc1cnc2c(Cl)cccc2c1-c1cccc(Oc2cccc(S(C)(=O)=O)c2)c1 | Homo sapiens | CHEMBL1047697 | single protein format |
| CHEMBL606539 |  |
IC50 | = | 1.2 | nM | 500.02 | CS(=O)(=O)c1cccc(Oc2cccc(-c3c(Cc4ccccc4)cnc4c(Cl)cccc34)c2)c1 | Homo sapiens | CHEMBL1047697 | single protein format |
| CHEMBL594062 |  |
IC50 | = | 1.2 | nM | 540.54 | CS(=O)(=O)c1cccc(Oc2cccc(-n3c(Cc4ccc(F)cc4)nc4c(C(F)(F)F)cccc43)c2)c1 | Homo sapiens | CHEMBL1069926 | single protein format |
| CHEMBL605730 |  |
IC50 | = | 1.3 | nM | 500.42 | CS(=O)(=O)c1cccc(Oc2cccc(-n3c(C(F)(F)F)nc4c(C(F)(F)F)cccc43)c2)c1 | Homo sapiens | CHEMBL1069926 | single protein format |
| CHEMBL593472 |  |
IC50 | = | 1.4 | nM | 501.53 | Cc1cnc2c(C(F)(F)F)cccc2c1-c1cccc(Oc2cccc(S(=O)(=O)CCCO)c2)c1 | Homo sapiens | CHEMBL1047697 | single protein format |
| CHEMBL594063 |  |
IC50 | = | 1.5 | nM | 440.95 | CC(C)c1nc2c(Cl)cccc2n1-c1cccc(Oc2cccc(S(C)(=O)=O)c2)c1 | Homo sapiens | CHEMBL1069926 | single protein format |
| CHEMBL593473 |  |
IC50 | = | 1.6 | nM | 471.5 | CCS(=O)(=O)c1cccc(Oc2cccc(-c3c(C)cnc4c(C(F)(F)F)cccc34)c2)c1 | Homo sapiens | CHEMBL1047697 | single protein format |
| CHEMBL595936 |  |
IC50 | = | 1.7 | nM | 460.48 | CCc1nc2c(C(F)(F)F)cccc2n1-c1cccc(Oc2cccc(S(C)(=O)=O)c2)c1 | Homo sapiens | CHEMBL1069926 | single protein format |
| CHEMBL595113 |  |
IC50 | = | 1.8 | nM | 485.53 | Cc1cnc2c(C(F)(F)F)cccc2c1-c1cccc(Oc2cccc(S(=O)(=O)C(C)C)c2)c1 | Homo sapiens | CHEMBL1047697 | single protein format |
| CHEMBL594175 |  |
IC50 | = | 1.9 | nM | 475.46 | Cc1cnc2c(C(F)(F)F)cccc2c1-c1cccc(Oc2cc(F)cc(S(C)(=O)=O)c2)c1 | Homo sapiens | CHEMBL1047697 | single protein format |
| CHEMBL555373 |  |
IC50 | = | 2.0 | nM | 530.71 | CC1(C(=O)OC(=O)C2(C)CCC[C@]3(C)c4cc(O)ccc4CC[C@@H]23)CCCC2(C)c3cc(O)ccc3CCC12 | Homo sapiens | CHEMBL828112 | assay format |
| CHEMBL215108 |  |
IC50 | = | 2.0 | nM | 527.29 | CCN(Cc1nc(-c2cccc(Cl)c2)oc1C)c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1Cl | Homo sapiens | CHEMBL912135 | single protein format |