Q13131 | AAPK1_HUMAN | 5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 29~279 | |
| PF16579 | AdenylateSensor - Adenylate sensor of SNF1-like protein kinase | 406~480 | |
| PF21147 | AMPK_alpha_AID - AMP-activated protein kinase, alpha subunit, autoinhibitory domain | 299~344 |
3D structures mapped by conservation among orthologs
[ Domain: "Kinase associated domain 1, KA1" // AdenylateSensor_1 ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Domain: "Protein kinase" // Pkinase_Tyr,UBA_AID_AMPKalpha ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3780091 |  |
IC50 | = | 5.5 | nM | 323.4 | N[C@H]1CC[C@@H](Nc2cc[nH]c(=O)c2-c2nc3ccccc3[nH]2)CC1 | Homo sapiens | CHEMBL3784665 | single protein format |
| CHEMBL4580220 |  |
IC50 | = | 10.0 | nM | 468.54 | CCc1ccccc1C(=O)Nc1n[nH]c2c(C)c(F)c(C3C(C#N)=C(C)N(C)C(C)=C3C#N)cc12 | Homo sapiens | CHEMBL4884218 | single protein format |
| CHEMBL4794096 |  |
IC50 | = | 93.0 | nM | 405.5 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(C#N)cc32)c1C | Homo sapiens | CHEMBL4769103 | single protein format |
| CHEMBL4781578 |  |
IC50 | = | 107.0 | nM | 451.57 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(CCC(N)=O)cc32)c1C | Homo sapiens | CHEMBL4769103 | single protein format |
| CHEMBL1231206 |  |
IC50 | = | 117.0 | nM | 374.47 | Cc1ccc(-c2ccc3c(ccc4sc5c(c43)NC[C@@H](C)NC5=O)n2)cn1 | Homo sapiens | CHEMBL5212746 | single protein format |
| CHEMBL13976 |  |
IC50 | = | 136.0 | nM | 370.43 | Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NCCN(C)C | Homo sapiens | CHEMBL4769103 | single protein format |
| CHEMBL4796639 |  |
IC50 | = | 139.0 | nM | 449.56 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(CCN=[N+]=[N-])cc32)c1C | Homo sapiens | CHEMBL4769103 | single protein format |
| CHEMBL4788980 |  |
IC50 | = | 152.0 | nM | 412.51 | CCN(CC)CCCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C | Homo sapiens | CHEMBL4769103 | single protein format |
| CHEMBL535 |  |
IC50 | = | 158.0 | nM | 398.48 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C | Homo sapiens | CHEMBL4769103 | single protein format |
| CHEMBL4788376 |  |
IC50 | = | 164.0 | nM | 433.56 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(CCC#N)cc32)c1C | Homo sapiens | CHEMBL4769103 | single protein format |
| CHEMBL4800500 |  |
IC50 | = | 173.0 | nM | 424.55 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(CCO)cc32)c1C | Homo sapiens | CHEMBL4769103 | single protein format |
| CHEMBL3542344 |  |
IC50 | = | 180.0 | nM | 370.43 | CCNCCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C | Homo sapiens | CHEMBL4769103 | single protein format |
| CHEMBL4795330 |  |
IC50 | = | 184.0 | nM | 465.6 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(CCNC(C)=O)cc32)c1C | Homo sapiens | CHEMBL4769103 | single protein format |
| CHEMBL5281003 |  |
IC50 | = | 202.0 | nM | 461.5 | COc1cccc(F)c1-c1nccc(C(=O)Nc2ccc3c(ncn3C)c2N2CC[C@@H](N)C2)n1 | Homo sapiens | CHEMBL5225834 | single protein format |
| CHEMBL4792246 |  |
IC50 | = | 205.0 | nM | 452.56 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(CNC(N)=O)cc32)c1C | Homo sapiens | CHEMBL4769103 | single protein format |
| CHEMBL4782796 |  |
IC50 | = | 208.0 | nM | 459.39 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3cc(Br)ccc32)c1C | Homo sapiens | CHEMBL4769103 | single protein format |
| CHEMBL4786972 |  |
IC50 | = | 217.0 | nM | 414.94 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3cc(Cl)ccc32)c1C | Homo sapiens | CHEMBL4769103 | single protein format |
| CHEMBL4799580 |  |
IC50 | = | 221.0 | nM | 384.46 | Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NCCCN(C)C | Homo sapiens | CHEMBL4769103 | single protein format |
| CHEMBL4779166 |  |
IC50 | = | 240.0 | nM | 398.48 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3cc(F)ccc32)c1C | Homo sapiens | CHEMBL4769103 | single protein format |
| CHEMBL275117 |  |
IC50 | = | 246.0 | nM | 380.49 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccccc32)c1C | Homo sapiens | CHEMBL4769103 | single protein format |