Q13126 | MTAP_HUMAN | S-methyl-5'-thioadenosine phosphorylase (MTAP)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01048 | PNP_UDP_1 - Phosphorylase superfamily | 11~255 |
3D structures mapped by conservation among orthologs
[ Domain: "Peptidyl-tRNA hydrolase-like" // PNP_UDP_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL554896 |  |
IC50 | = | 1.2 | nM | 331.83 | CSC[C@H]1N[C@@H](c2c[nH]c3c(N)ncnc23)[C@H](O)[C@@H]1O.Cl | Homo sapiens | CHEMBL713611 | single protein format |
| CHEMBL405346 |  |
Ki | = | 0.09 | nM | 293.4 | CSC[C@H]1CN(Cc2c[nH]c3c(N)ncnc23)C[C@@H]1O | Homo sapiens | CHEMBL931723 | single protein format |
| CHEMBL365378 |  |
Ki | = | 0.28 | nM | 337.49 | CCCCSCC1CN(Cc2c[nH]c3c2NC=NC3N)CC1O | Homo sapiens | CHEMBL827883 | single protein format |
| CHEMBL365813 |  |
Ki | = | 0.36 | nM | 391.93 | NC1N=CNc2c(CN3CC(O)C(CSc4ccc(Cl)cc4)C3)c[nH]c21 | Homo sapiens | CHEMBL827883 | single protein format |
| CHEMBL552894 |  |
Ki | = | 0.576 | nM | 428.35 | Cl.Nc1[nH]cnc2c(C3NC(CSc4ccc(Cl)cc4)C(O)C3O)cnc1-2 | Homo sapiens | CHEMBL615270 | single protein format |
| CHEMBL191544 |  |
Ki | = | 0.65 | nM | 309.44 | CCSCC1CN(Cc2c[nH]c3c2NC=NC3N)CC1O | Homo sapiens | CHEMBL827883 | single protein format |
| CHEMBL190867 |  |
Ki | = | 0.76 | nM | 363.53 | NC1N=CNc2c(CN3CC(O)C(CSC4CCCCC4)C3)c[nH]c21 | Homo sapiens | CHEMBL827883 | single protein format |
| CHEMBL1243249 |  |
Ki | = | 0.8 | nM | 289.38 | CCCC[C@H]1CN(Cc2c[nH]c3c(N)ncnc23)C[C@@H]1O | Homo sapiens | CHEMBL1246404 | single protein format |
| CHEMBL190216 |  |
Ki | = | 0.81 | nM | 375.47 | NC1N=CNc2c(CN3CC(O)C(CSc4ccc(F)cc4)C3)c[nH]c21 | Homo sapiens | CHEMBL827883 | single protein format |
| CHEMBL191281 |  |
Ki | = | 0.9 | nM | 323.47 | CC(C)SCC1CN(Cc2c[nH]c3c2NC=NC3N)CC1O | Homo sapiens | CHEMBL827883 | single protein format |
| CHEMBL1195586 |  |
Ki | = | 1.0 | nM | 295.37 | CSC[C@H]1N[C@@H](c2c[nH]c3c(N)ncnc23)[C@H](O)[C@@H]1O | Homo sapiens | CHEMBL2073357 | single protein format |
| CHEMBL425188 |  |
Ki | = | 1.3 | nM | 323.47 | CCCSCC1CN(Cc2c[nH]c3c2NC=NC3N)CC1O | Homo sapiens | CHEMBL827883 | single protein format |
| CHEMBL542449 |  |
Ki | = | 1.39 | nM | 407.93 | Cc1cccc(SCC2NC(c3c[nH]c4c(N)ncnc34)C(O)C2O)c1.Cl | Homo sapiens | CHEMBL615270 | single protein format |
| CHEMBL191436 |  |
Ki | = | 1.4 | nM | 369.49 | Nc1[nH]cnc2c(CN3CC(O)C(CSCc4ccccc4)C3)cnc1-2 | Homo sapiens | CHEMBL827883 | single protein format |
| CHEMBL188034 |  |
Ki | = | 1.5 | nM | 357.48 | NC1N=CNc2c(CN3CC(O)C(CSc4ccccc4)C3)c[nH]c21 | Homo sapiens | CHEMBL827883 | single protein format |
| CHEMBL1243250 |  |
Ki | = | 1.7 | nM | 289.38 | CC(C)C[C@H]1CN(Cc2c[nH]c3c(N)ncnc23)C[C@@H]1O | Homo sapiens | CHEMBL1246404 | single protein format |
| CHEMBL188375 |  |
Ki | = | 1.7 | nM | 293.4 | CSCC1CN(Cc2c[nH]c3c(N)ncnc23)CC1O | Homo sapiens | CHEMBL827883 | single protein format |
| CHEMBL190139 |  |
Ki | = | 2.0 | nM | 358.47 | NC1N=CNc2c(CN3CC(O)C(CSc4ccncc4)C3)c[nH]c21 | Homo sapiens | CHEMBL827883 | single protein format |
| CHEMBL405371 |  |
Ki | = | 2.0 | nM | 263.37 | CSCC1CN(Cc2c[nH]c3c(N)ncnc23)C1 | Homo sapiens | CHEMBL931723 | single protein format |
| CHEMBL191177 |  |
Ki | = | 2.0 | nM | 391.93 | NC1N=CNc2c(CN3CC(O)C(CSc4cccc(Cl)c4)C3)c[nH]c21 | Homo sapiens | CHEMBL827883 | single protein format |