Q13093 | PAFA_HUMAN | Platelet-activating factor acetylhydrolase (PLA2G7)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF03403 | PAF-AH_p_II - Platelet-activating factor acetylhydrolase, isoform II | 49~416 |
3D structures mapped by conservation among orthologs
[ Domain: "alpha/beta-Hydrolases" // Hydrolase_4 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL87729 |  |
IC50 | = | 0.1 | nM | 553.75 | CCCCCCCCCCNC(=O)CCCn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1 | Homo sapiens | CHEMBL707412 | cell-free format |
| CHEMBL85885 |  |
IC50 | = | 0.3 | nM | 553.75 | CCCCCCCCCCCCNC(=O)Cn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1 | Homo sapiens | CHEMBL707412 | cell-free format |
| CHEMBL421165 |  |
IC50 | = | 0.4 | nM | 525.69 | CCCCCCCCNC(=O)CCCn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1 | Homo sapiens | CHEMBL707412 | cell-free format |
| CHEMBL153142 |  |
IC50 | = | 0.9 | nM | 581.72 | Cc1ccc(-c2ccc(CN(C)C(=O)Cn3cc(Cc4cnn(C)c4)c(=O)nc3SCc3ccc(F)cc3)cc2)cc1 | Homo sapiens | CHEMBL707411 | single protein format |
| CHEMBL87741 |  |
IC50 | = | 1.0 | nM | 567.78 | CCCCCCCCCCCCN(C)C(=O)Cn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1 | Homo sapiens | CHEMBL707412 | cell-free format |
| CHEMBL57713 |  |
IC50 | = | 1.0 | nM | 597.8 | CCCCCCCCCCCCN(C)C(=O)Cn1cc(Cc2cnc(OC)nc2)c(=O)nc1SCc1ccc(F)cc1 | Homo sapiens | CHEMBL767153 | single protein format |
| CHEMBL3792774 |  |
IC50 | = | 1.1 | nM | 561.89 | CCOC(=O)CN(C)c1cc(OCc2cc(F)c(Oc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)nc(=O)n1C | Homo sapiens | CHEMBL3796340 | single protein format |
| CHEMBL3792873 |  |
IC50 | = | 1.1 | nM | 559.92 | COC1CCN(c2cc(OCc3cc(F)c(Oc4ccc(Cl)c(C(F)(F)F)c4)c(F)c3)nc(=O)n2C)CC1 | Homo sapiens | CHEMBL3796340 | single protein format |
| CHEMBL3792756 |  |
IC50 | = | 1.2 | nM | 533.88 | COCCN(C)c1cc(OCc2cc(F)c(Oc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)nc(=O)n1C | Homo sapiens | CHEMBL3796340 | single protein format |
| CHEMBL3818650 |  |
IC50 | = | 1.4 | nM | 410.52 | COC(CO)Cn1ccc(Nc2cc(-c3ccccc3C)c(C)cc2OCCN)n1 | Homo sapiens | CHEMBL3820395 | single protein format |
| CHEMBL152387 |  |
IC50 | = | 1.6 | nM | 588.11 | Cn1cc(Cc2cn(CC(=O)NCc3ccc(-c4ccc(Cl)cc4)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1 | Homo sapiens | CHEMBL707411 | single protein format |
| CHEMBL3794023 |  |
IC50 | = | 1.6 | nM | 531.87 | Cn1c(N2CCOCC2)cc(OCc2cc(F)c(Oc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)nc1=O | Homo sapiens | CHEMBL3796340 | single protein format |
| CHEMBL3792924 |  |
IC50 | = | 1.7 | nM | 579.93 | Cn1c(N2CCS(=O)(=O)CC2)cc(OCc2cc(F)c(Oc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)nc1=O | Homo sapiens | CHEMBL3796340 | single protein format |
| CHEMBL3793007 |  |
IC50 | = | 1.8 | nM | 547.93 | Cn1c(N2CCSCC2)cc(OCc2cc(F)c(Oc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)nc1=O | Homo sapiens | CHEMBL3796340 | single protein format |
| CHEMBL3792761 |  |
IC50 | = | 1.8 | nM | 570.95 | Cn1c(N2CCN(C3CC3)CC2)cc(OCc2cc(F)c(Oc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)nc1=O | Homo sapiens | CHEMBL3796340 | single protein format |
| CHEMBL3794575 |  |
IC50 | = | 1.9 | nM | 495.89 | Cn1c(N2CCOCC2)cc(OCc2ccc(Oc3ccc(Cl)c(C(F)(F)F)c3)cc2)nc1=O | Homo sapiens | CHEMBL3796340 | single protein format |
| CHEMBL82956 |  |
IC50 | = | 2.0 | nM | 511.67 | CCCCCCCNC(=O)CCCn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1 | Homo sapiens | CHEMBL707412 | cell-free format |
| CHEMBL83522 |  |
IC50 | = | 2.0 | nM | 563.67 | O=C(Cn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1)NCCCCCCc1ccc(F)cc1 | Homo sapiens | CHEMBL707412 | cell-free format |
| CHEMBL3793506 |  |
IC50 | = | 2.2 | nM | 520.9 | Cn1c(N2CCOCC2)cc(OCc2ccc(Oc3ccc(Cl)c(C(F)(F)F)c3)c(C#N)c2)nc1=O | Homo sapiens | CHEMBL3796340 | single protein format |
| CHEMBL3794220 |  |
IC50 | = | 2.2 | nM | 547.88 | Cn1c(N2CCC(F)CC2)cc(OCc2cc(F)c(Oc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)nc1=O | Homo sapiens | CHEMBL3796340 | single protein format |