Q13085 | ACACA_HUMAN | Acetyl-CoA carboxylase 1 (ACACA)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00289 | Biotin_carb_N - Biotin carboxylase, N-terminal domain | 118~237 | |
| PF00364 | Biotin_lipoyl - Biotin-requiring enzyme | 753~818 | |
| PF01039 | Carboxyl_trans - Carboxyl transferase domain | 1669~2222 | |
| PF02785 | Biotin_carb_C - Biotin carboxylase C-terminal domain | 508~614 | |
| PF02786 | CPSase_L_D2 - Carbamoyl-phosphate synthase L chain, ATP binding domain | 288~471 | |
| PF08326 | ACC_central - Acetyl-CoA carboxylase, central region | 819~1569 | |
| PF21385 | ACCA_BT - Acetyl-CoA carboxylase, BT domain | 627~746 |
3D structures mapped by conservation among orthologs
[ Domain: "Four-helical bundle in acetyl-CoA carboxylase" // ACC_central_1st_1 ]
[ Domain: "Helical domain in acetyl-CoA carboxylase" // ACC_central_1st ]
[ Domain: "Barrel domain in methylcrotonyl-CoA carboxylase alpha-subunit" // KOG0368 ]
[ Domain: "ATP-grasp" // ATP-grasp ]
[ Domain: "CO dehydrogenase molybdoprotein N-domain-like" // Biotin_carb_C ]
[ Domain: "Single hybrid motif" // Biotin_lipoyl ]
[ Domain: "PreATP-grasp domain" // Biotin_carb_N ]
[ Domain: "Acetyl-CoA carboxylase AC4 and AC5 domains" // ACC_central_2nd ]
[ Domain: "ClpP/crotonase" // Carboxyl_trans_C ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4073202 |  |
IC50 | = | 0.58 | nM | 423.47 | C[C@@H](COc1cnc(-c2ccc(Oc3cccc(OCC4CC4)c3)cc2)o1)NC(N)=O | Homo sapiens | CHEMBL4027523 | cell-based format |
| CHEMBL5404551 |  |
IC50 | = | 0.9 | nM | 545.71 | CN(C)c1cc(C(=O)N2CCC3(CC2)CC(=O)c2nc(C(C)(C)C)sc2C3)cc(-c2ccc(C(N)=O)cc2)n1 | Homo sapiens | CHEMBL5338512 | cell-based format |
| CHEMBL4085633 |  |
IC50 | = | 0.96 | nM | 422.48 | CC(=O)N[C@@H](C)COc1cnc(-c2ccc(Oc3cccc(OCC4CC4)c3)cc2)o1 | Homo sapiens | CHEMBL4027523 | cell-based format |
| CHEMBL4086127 |  |
IC50 | = | 0.96 | nM | 423.47 | CC(=O)N[C@@H](C)COc1cnc(-c2ccc(Oc3cccc(OCC4CC4)c3)nc2)o1 | Homo sapiens | CHEMBL4027523 | cell-based format |
| CHEMBL4777068 |  |
IC50 | = | 1.29 | nM | 509.61 | CC(C)(C)n1cc2c(n1)C(=O)CC1(CCN(C(=O)c3cc(-c4ccc(N)cc4)nc4ccccc34)CC1)O2 | Homo sapiens | CHEMBL4735021 | cell-based format |
| CHEMBL5411569 |  |
IC50 | = | 1.3 | nM | 486.04 | COc1cc(C(=O)N2CCC3(CC2)CC(=O)c2nc(C(C)(C)C)sc2C3)c2[nH]ccc2c1Cl | Homo sapiens | CHEMBL5338512 | cell-based format |
| CHEMBL5435853 |  |
IC50 | = | 1.3 | nM | 471.03 | Cc1cc(C(=O)N2CCC3(CC2)CC(=O)c2nc(C(C)(C)C)sc2C3)c2[nH]ncc2c1Cl | Homo sapiens | CHEMBL5338512 | cell-based format |
| CHEMBL4528475 |  |
IC50 | = | 1.5 | nM | 444.49 | CC(NC(N)=O)c1ccc2nc(-c3ccc(Oc4cccc(OCC5CC5)c4)nc3)oc2c1 | Homo sapiens | CHEMBL4410467 | cell-based format |
| CHEMBL5411576 |  |
IC50 | = | 1.5 | nM | 492.65 | CNc1ccc2c(OC)cc(C(=O)N3CCC4(CC3)CC(=O)c3nc(C(C)(C)C)sc3C4)cc2n1 | Homo sapiens | CHEMBL5338512 | cell-based format |
| CHEMBL5401918 |  |
IC50 | = | 1.8 | nM | 476.65 | CNc1nc2c(C)cccc2cc1C(=O)N1CCC2(CC1)CC(=O)c1nc(C(C)(C)C)sc1C2 | Homo sapiens | CHEMBL5338512 | cell-based format |
| CHEMBL2419600 |  |
IC50 | = | 1.8 | nM | 474.61 | CCCNc1ccc2ccc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc2n1 | Homo sapiens | CHEMBL2422748 | single protein format |
| CHEMBL4060253 |  |
IC50 | = | 1.8 | nM | 443.5 | CC(=O)NC(C)c1ccc2nc(-c3ccc(Oc4cccc(OCC5CC5)c4)nc3)oc2c1 | Homo sapiens | CHEMBL4027523 | cell-based format |
| CHEMBL4435891 |  |
IC50 | = | 2.1 | nM | 472.55 | CC(NC(=O)N(C)C)c1ccc2nc(-c3ccc(Oc4cccc(OCC5CC5)c4)nc3)oc2c1 | Homo sapiens | CHEMBL4410467 | cell-based format |
| CHEMBL5436442 |  |
IC50 | = | 2.2 | nM | 494.66 | CCOc1cc(C(=O)N2CCC3(CC2)CC(=O)c2nc(C(C)(C)C)sc2C3)cc2c(C)nn(C)c12 | Homo sapiens | CHEMBL5338512 | cell-based format |
| CHEMBL2323626 |  |
IC50 | = | 2.2 | nM | 445.57 | CNc1ccc2ccc(C(=O)N3CCC4(CC3)CC(=O)c3nn(C(C)(C)C)cc3C4)cc2n1 | Homo sapiens | CHEMBL2329346 | single protein format |
| CHEMBL4792495 |  |
IC50 | = | 2.22 | nM | 508.62 | Cc1ccc(-c2cc(C(=O)N3CCC4(CC3)CC(=O)c3nn(C(C)(C)C)cc3O4)c3ccccc3n2)cc1 | Homo sapiens | CHEMBL4735021 | cell-based format |
| CHEMBL3407547 |  |
IC50 | = | 2.6 | nM | 569.64 | COc1ccccc1[C@H](Cn1c(=O)n(C(C)(C)C(=O)O)c(=O)c2c(C)c(-c3ncco3)sc21)OC1CCOCC1 | Homo sapiens | CHEMBL3412273 | single protein format |
| CHEMBL4777090 |  |
IC50 | = | 2.72 | nM | 537.66 | CN(C)c1ccc(-c2cc(C(=O)N3CCC4(CC3)CC(=O)c3nn(C(C)(C)C)cc3O4)c3ccccc3n2)cc1 | Homo sapiens | CHEMBL4735021 | cell-based format |
| CHEMBL4557289 |  |
IC50 | = | 3.0 | nM | 565.63 | COc1cc(C(=O)N2CCC3(CC2)CC(=O)c2cc(-c4cncc(C(=O)O)c4)ccc2O3)cc2c1c(C)cn2C1CC1 | Homo sapiens | CHEMBL4344283 | single protein format |
| CHEMBL4793476 |  |
IC50 | = | 3.18 | nM | 524.62 | COc1ccc(-c2cc(C(=O)N3CCC4(CC3)CC(=O)c3nn(C(C)(C)C)cc3O4)c3ccccc3n2)cc1 | Homo sapiens | CHEMBL4735021 | cell-based format |