Q12931 | TRAP1_HUMAN | Heat shock protein 75 kDa, mitochondrial (TRAP1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00183 | HSP90 - Hsp90 protein | 291~702 | |
| PF13589 | HATPase_c_3 - Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase | 110~222 |
3D structures mapped by conservation among orthologs
[ Domain: "Ribosomal protein S5 domain 2-like" // HSP90_1st ]
[ Domain: "ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase" // HATPase_c ]
[ Domain: "HSP90 C-terminal a/b domain" // HSP90_2nd ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2103879 |  |
IC50 | = | 51.0 | nM | 364.41 | CC(C)c1cc(-c2n[nH]c(=O)n2-c2ccc3c(ccn3C)c2)c(O)cc1O | Homo sapiens | CHEMBL2424065 | single protein format |
| CHEMBL4866705 |  |
IC50 | = | 58.0 | nM | 372.58 | Nc1nc(Cl)c2nc(O)n(Cc3ccc(Br)cc3F)c2n1 | Homo sapiens | CHEMBL4824939 | single protein format |
| CHEMBL4863672 |  |
IC50 | = | 62.4 | nM | 307.72 | Cc1ccc(Cn2c(O)nc3c(Cl)nc(N)nc32)c(F)c1 | Homo sapiens | CHEMBL4824939 | single protein format |
| CHEMBL4864922 |  |
IC50 | = | 63.5 | nM | 360.66 | Nc1nc(Cl)c2nc(S)n(Cc3ccc(Cl)c(Cl)c3)c2n1 | Homo sapiens | CHEMBL4824939 | single protein format |
| CHEMBL4869481 |  |
IC50 | = | 65.8 | nM | 398.6 | Nc1nc(Cl)c2nc(O)n(Cc3cc4c(cc3Br)OCO4)c2n1 | Homo sapiens | CHEMBL4824939 | single protein format |
| CHEMBL4879021 |  |
IC50 | = | 76.6 | nM | 344.59 | Nc1nc(Cl)c2nc(O)n(Cc3ccc(Cl)c(Cl)c3)c2n1 | Homo sapiens | CHEMBL4824939 | single protein format |
| CHEMBL4068596 |  |
IC50 | = | 79.0 | nM | 382.61 | Nc1nc(Cl)c2cnn(Cc3cc4c(cc3Br)OCO4)c2n1 | Homo sapiens | CHEMBL4019095 | assay format |
| CHEMBL4866958 |  |
IC50 | = | 81.5 | nM | 343.6 | Nc1nc(Cl)c2c(n1)N(Cc1ccc(Cl)c(Cl)c1)C(=O)C2 | Homo sapiens | CHEMBL4824939 | single protein format |
| CHEMBL4876871 |  |
IC50 | = | 82.7 | nM | 323.78 | Cc1ccc(Cn2c(S)nc3c(Cl)nc(N)nc32)c(F)c1 | Homo sapiens | CHEMBL4824939 | single protein format |
| CHEMBL4863988 |  |
IC50 | = | 89.9 | nM | 306.73 | Cc1ccc(CN2C(=O)Cc3c(Cl)nc(N)nc32)c(F)c1 | Homo sapiens | CHEMBL4824939 | single protein format |
| CHEMBL467399 |  |
IC50 | = | 90.0 | nM | 318.77 | COc1c(C)cnc(Cn2cnc3c(Cl)nc(N)nc32)c1C | Homo sapiens | CHEMBL2424065 | single protein format |
| CHEMBL4871630 |  |
IC50 | = | 100.0 | nM | 371.6 | Nc1nc(Cl)c2c(n1)N(Cc1ccc(Br)cc1F)C(=O)C2 | Homo sapiens | CHEMBL4824939 | single protein format |
| CHEMBL4080323 |  |
IC50 | = | 138.0 | nM | 318.77 | COc1c(C)cnc(Cn2ncc3c(Cl)nc(N)nc32)c1C | Homo sapiens | CHEMBL4019095 | assay format |
| CHEMBL4857569 |  |
IC50 | = | 170.0 | nM | 378.14 | Nc1nc(Cl)c2nc(O)n(Cc3cc(C(F)(F)F)ccc3Cl)c2n1 | Homo sapiens | CHEMBL4824939 | single protein format |
| CHEMBL4860652 |  |
IC50 | = | 178.0 | nM | 357.77 | COc1cc(F)c(Cn2c(S)nc3c(Cl)nc(N)nc32)c(F)c1 | Homo sapiens | CHEMBL4824939 | single protein format |
| CHEMBL3360305 |  |
IC50 | = | 200.0 | nM | 379.4 | COc1cccc(-c2cc(F)ccc2[C@H]2Cc3nc(N)nc(C)c3C(=O)N2)n1 | Homo sapiens | CHEMBL4124123 | assay format |
| CHEMBL200102 |  |
IC50 | = | 205.0 | nM | 512.38 | CC(C)NCCCn1c(Sc2cc3c(cc2I)OCO3)nc2c(N)ncnc21 | Homo sapiens | CHEMBL2424065 | single protein format |
| CHEMBL4850126 |  |
IC50 | = | 230.0 | nM | 340.72 | COc1ccc(F)c(CN2C(=O)Cc3c(Cl)nc(N)nc32)c1F | Homo sapiens | CHEMBL4824939 | single protein format |
| CHEMBL4846028 |  |
IC50 | = | 243.0 | nM | 328.13 | Nc1nc(Cl)c2nc(O)n(Cc3cc(Cl)ccc3F)c2n1 | Homo sapiens | CHEMBL4824939 | single protein format |
| CHEMBL4870087 |  |
IC50 | = | 296.0 | nM | 397.62 | Nc1nc(Cl)c2c(n1)N(Cc1cc3c(cc1Br)OCO3)C(=O)C2 | Homo sapiens | CHEMBL4824939 | single protein format |