Q12908 | NTCP2_HUMAN | Ileal sodium/bile acid cotransporter (SLC10A2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01758 | SBF - Sodium Bile acid symporter family | 39~217 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL370103 |  |
IC50 | = | 0.3 | nM | 573.76 | CCCCC1(CCCC)CS(=O)(=O)c2ccc(N(C)C)cc2[C@@H](c2cccc(NCC(=O)NCC(=O)O)c2)[C@H]1O | Homo sapiens | CHEMBL882493 | cell-based format |
| CHEMBL194685 |  |
IC50 | = | 0.75 | nM | 565.8 | CCCCC1(CCCC)CS(=O)(=O)c2ccc(N(C)C)cc2[C@@H](c2ccc(OCc3cc[n+](C)cc3)cc2)[C@H]1O | Homo sapiens | CHEMBL882493 | cell-based format |
| CHEMBL3658914 |  |
IC50 | = | 1.0 | nM | 559.73 | CCCC[C@]1(CC)CS(=O)(=O)c2cc(CNC(CC(=O)O)CC(=O)O)c(N(C)C)cc2[C@@H](c2ccccc2)N1 | Homo sapiens | CHEMBL3706108 | single protein format |
| CHEMBL372275 |  |
IC50 | = | 2.0 | nM | 503.71 | CCCCC1(CCCC)CS(=O)(=O)c2c(OC)cc(N(C)C)cc2[C@@H](c2ccc(OC)cc2)[C@H]1O | Homo sapiens | CHEMBL881968 | cell-based format |
| CHEMBL372324 |  |
IC50 | = | 2.0 | nM | 550.79 | CCCCC1(CCCC)CS(=O)(=O)c2ccc(N(C)C)cc2[C@@H](c2cccc(Nc3cc[n+](C)cc3)c2)[C@H]1O | Homo sapiens | CHEMBL882493 | cell-based format |
| CHEMBL2387520 |  |
IC50 | = | 2.0 | nM | 473.64 | CCCC[C@]1(CC)CS(=O)(=O)c2cc(CCCC(=O)O)c(OC)cc2[C@@H](c2ccccc2)N1 | Homo sapiens | CHEMBL2388857 | cell-based format |
| CHEMBL197508 |  |
IC50 | = | 2.0 | nM | 458.67 | CCCCC1(CCCC)CS(=O)(=O)c2ccc(N(C)C)cc2[C@@H](c2cccc(N)c2)[C@H]1O | Homo sapiens | CHEMBL882493 | cell-based format |
| CHEMBL2387421 |  |
IC50 | = | 2.0 | nM | 538.69 | CCCC[C@]1(CC)CS(=O)(=O)c2cc(C(=O)NCCS(=O)(=O)O)c(OC)cc2[C@@H](c2ccccc2)N1 | Homo sapiens | CHEMBL2388857 | cell-based format |
| CHEMBL3658901 |  |
IC50 | = | 2.0 | nM | 490.62 | CCCC[C@]1(CC)CS(=O)(=O)c2cc(CNCC(=O)O)c(OC)cc2[C@@H](c2ccccc2)N1O | Homo sapiens | CHEMBL3706108 | single protein format |
| CHEMBL3658886 |  |
IC50 | = | 2.0 | nM | 429.63 | CCCC[C@]1(CC)CS(=O)(=O)c2cc(CCC)c(OC)cc2[C@@H](c2ccccc2)N1 | Homo sapiens | CHEMBL3706108 | single protein format |
| CHEMBL194461 |  |
IC50 | = | 2.2 | nM | 459.65 | CCCCC1(CCCC)CS(=O)(=O)c2ccc(N(C)C)cc2[C@@H](c2ccc(O)cc2)[C@H]1O | Homo sapiens | CHEMBL882493 | cell-based format |
| CHEMBL3658876 |  |
IC50 | = | 3.0 | nM | 413.58 | C=Cc1cc2c(cc1OC)[C@@H](c1ccccc1)N[C@](CC)(CCCC)CS2(=O)=O | Homo sapiens | CHEMBL3706108 | single protein format |
| CHEMBL196459 |  |
IC50 | = | 3.6 | nM | 491.67 | CCCCC1(CCCC)CS(=O)(=O)c2ccc(N(C)C)cc2[C@@H](c2ccc(OC)c(F)c2)[C@H]1O | Homo sapiens | CHEMBL882493 | cell-based format |
| CHEMBL426152 |  |
IC50 | = | 3.7 | nM | 537.74 | CCCCC1(CCCC)CS(=O)(=O)c2ccc(N(C)C)cc2[C@@H](c2cccc(CS(=O)(=O)O)c2)[C@H]1O | Homo sapiens | CHEMBL882493 | cell-based format |
| CHEMBL2387521 |  |
IC50 | = | 4.0 | nM | 481.64 | CCCC[C@]1(CC)CS(=O)(=O)c2cc(CS(=O)(=O)O)c(OC)cc2[C@@H](c2ccccc2)N1 | Homo sapiens | CHEMBL2388857 | cell-based format |
| CHEMBL2387522 |  |
IC50 | = | 4.0 | nM | 509.69 | CCCC[C@]1(CC)CS(=O)(=O)c2cc(CCCS(=O)(=O)O)c(OC)cc2[C@@H](c2ccccc2)N1 | Homo sapiens | CHEMBL2388857 | cell-based format |
| CHEMBL2387397 |  |
IC50 | = | 4.0 | nM | 474.62 | CCCC[C@]1(CC)CS(=O)(=O)c2cc(CNCC(=O)O)c(OC)cc2[C@@H](c2ccccc2)N1 | Homo sapiens | CHEMBL2388857 | cell-based format |
| CHEMBL3658874 |  |
IC50 | = | 4.0 | nM | 401.57 | CCCC[C@]1(CC)CS(=O)(=O)c2cc(C)c(OC)cc2[C@@H](c2ccccc2)N1 | Homo sapiens | CHEMBL3706108 | single protein format |
| CHEMBL2387527 |  |
IC50 | = | 4.0 | nM | 511.66 | CCCC[C@]1(CC)CS(=O)(=O)c2cc(OCCS(=O)(=O)O)c(OC)cc2[C@@H](c2ccccc2)N1 | Homo sapiens | CHEMBL2388857 | cell-based format |
| CHEMBL197311 |  |
IC50 | = | 4.5 | nM | 473.68 | CCCCC1(CCCC)CS(=O)(=O)c2ccc(N(C)C)cc2[C@@H](c2cccc(CO)c2)[C@H]1O | Homo sapiens | CHEMBL882493 | cell-based format |