Q12882 | DPYD_HUMAN | Dihydropyrimidine dehydrogenase [NADP(+)] (DPYD)
Pfam Domain Table
Accession | Domain | Range | Color |
---|---|---|---|
PF01180 | DHO_dh - Dihydroorotate dehydrogenase | 534~838 | |
PF07992 | Pyr_redox_2 - Pyridine nucleotide-disulphide oxidoreductase | 189~494 | |
PF14691 | Fer4_20 - Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster | 57~166 | |
PF14697 | Fer4_21 - 4Fe-4S dicluster domain | 946~1004 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
---|---|---|---|---|---|---|---|---|---|---|
CHEMBL355200 | IC50 | = | 14.0 | nM | 136.11 | C#Cc1c[nH]c(=O)[nH]c1=O | Homo sapiens | CHEMBL665825 | single protein format | |
CHEMBL352944 | IC50 | = | 43.0 | nM | 214.22 | Oc1ncc(/C=C/c2ccccc2)c(O)n1 | Homo sapiens | CHEMBL665825 | single protein format | |
CHEMBL170188 | IC50 | = | 89.0 | nM | 138.13 | C=Cc1cnc(O)nc1O | Homo sapiens | CHEMBL665825 | single protein format | |
CHEMBL127691 | IC50 | = | 97.0 | nM | 308.34 | Oc1ncc(Cc2cccc(OCc3ccccc3)c2)c(O)n1 | Homo sapiens | CHEMBL665825 | single protein format | |
CHEMBL443038 | IC50 | = | 200.0 | nM | 137.1 | N#Cc1cnc(O)nc1O | Homo sapiens | CHEMBL665825 | single protein format | |
CHEMBL1173 | IC50 | = | 220.0 | nM | 237.98 | O=c1[nH]cc(I)c(=O)[nH]1 | Homo sapiens | CHEMBL665825 | single protein format |