Q12882 | DPYD_HUMAN | Dihydropyrimidine dehydrogenase [NADP(+)] (DPYD)

Pfam Domain Table

AccessionDomainRangeColor
PF01180DHO_dh - Dihydroorotate dehydrogenase534~838
PF07992Pyr_redox_2 - Pyridine nucleotide-disulphide oxidoreductase189~494
PF14691Fer4_20 - Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster57~166
PF14697Fer4_21 - 4Fe-4S dicluster domain946~1004

3D structures mapped by conservation among orthologs


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL355200 IC50 = 14.0 nM 136.11 C#Cc1c[nH]c(=O)[nH]c1=O Homo sapiens CHEMBL665825 single protein format
CHEMBL352944 IC50 = 43.0 nM 214.22 Oc1ncc(/C=C/c2ccccc2)c(O)n1 Homo sapiens CHEMBL665825 single protein format
CHEMBL170188 IC50 = 89.0 nM 138.13 C=Cc1cnc(O)nc1O Homo sapiens CHEMBL665825 single protein format
CHEMBL127691 IC50 = 97.0 nM 308.34 Oc1ncc(Cc2cccc(OCc3ccccc3)c2)c(O)n1 Homo sapiens CHEMBL665825 single protein format
CHEMBL443038 IC50 = 200.0 nM 137.1 N#Cc1cnc(O)nc1O Homo sapiens CHEMBL665825 single protein format
CHEMBL1173 IC50 = 220.0 nM 237.98 O=c1[nH]cc(I)c(=O)[nH]1 Homo sapiens CHEMBL665825 single protein format