Q12852 | M3K12_HUMAN | Mitogen-activated protein kinase kinase kinase 12 (MAP3K12)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 131~363 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5286166 |  |
IC50 | = | 2.0 | nM | 512.47 | CCOC(=O)N1C[C@@H]2C[C@H]1CN2c1nc(-c2cnc(N)c(OC(F)F)n2)cc(N2CCC(F)(F)C2)n1 | Homo sapiens | CHEMBL5239394 | cell-based format |
| CHEMBL5272522 |  |
IC50 | = | 2.0 | nM | 488.5 | CCOC(=O)N1C[C@@H]2C[C@H]1CN2c1nc(-c2cnc(N)c(OC(F)F)n2)cc(N2CC3CC2C3)n1 | Homo sapiens | CHEMBL5239394 | cell-based format |
| CHEMBL5287658 |  |
IC50 | = | 2.0 | nM | 451.49 | CC(C)C(O)c1nc(-c2cnc(N)c(C(F)(F)F)c2)cn1C12CC(N3CCOCC3)(C1)C2 | Homo sapiens | CHEMBL5239392 | single protein format |
| CHEMBL5281494 |  |
IC50 | = | 3.0 | nM | 473.48 | COC(=O)N1C[C@@H]2C[C@H]1CN2c1cc(-c2cnc(N)c(OC(F)F)n2)cc(N2CC3CC2C3)n1 | Homo sapiens | CHEMBL5239394 | cell-based format |
| CHEMBL5283101 |  |
IC50 | = | 3.0 | nM | 447.45 | CCOC(=O)N1C[C@@H]2C[C@H]1CN2c1nc(-c2cnc(N)c(OC(F)F)n2)cc(C2CC2)n1 | Homo sapiens | CHEMBL5239394 | cell-based format |
| CHEMBL5288706 |  |
IC50 | = | 3.0 | nM | 453.48 | CCOC(=O)N1C[C@@H]2C[C@H]1CN2c1nc(SC)cc(-c2cnc(N)c(OC(F)F)n2)n1 | Homo sapiens | CHEMBL5239394 | cell-based format |
| CHEMBL5271665 |  |
IC50 | = | 4.0 | nM | 532.51 | Cc1ccc(N2C[C@@H]3C[C@H]2CN3c2nc(-c3cnc(N)c(OC(F)F)n3)cc(N3CCC(F)(F)C3)n2)nn1 | Homo sapiens | CHEMBL5239394 | cell-based format |
| CHEMBL5271972 |  |
IC50 | = | 4.0 | nM | 417.42 | Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CC4CC3C4)n2)nc1OC(F)F | Homo sapiens | CHEMBL5239394 | cell-based format |
| CHEMBL5268969 |  |
IC50 | = | 4.0 | nM | 440.4 | Nc1ncc(-c2cc(N3CCC(F)(F)C3)nc(N3C[C@@H]4C[C@H]3CO4)c2)nc1OC(F)F | Homo sapiens | CHEMBL5239394 | cell-based format |
| CHEMBL3732012 |  |
IC50 | = | 11.0 | nM | 440.4 | Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F | Homo sapiens | CHEMBL5239392 | single protein format |
| CHEMBL5270353 |  |
IC50 | = | 12.0 | nM | 441.39 | Nc1ncc(-c2cc(N3CCC(F)(F)C3)nc(N3CC4CC(C3)O4)n2)nc1OC(F)F | Homo sapiens | CHEMBL5239394 | cell-based format |
| CHEMBL5276415 |  |
IC50 | = | 13.0 | nM | 406.39 | Nc1ncc(-c2cc([C@@H]3CCCO3)nc(N3C[C@@H]4C[C@H]3CO4)n2)nc1OC(F)F | Homo sapiens | CHEMBL5239394 | cell-based format |
| CHEMBL5268950 |  |
IC50 | = | 13.0 | nM | 382.4 | CSc1cc(-c2cnc(N)c(OC(F)F)n2)nc(N2C[C@@H]3C[C@H]2CO3)n1 | Homo sapiens | CHEMBL5239394 | cell-based format |
| CHEMBL5276337 |  |
IC50 | = | 13.0 | nM | 417.42 | Nc1ncc(-c2cc(N3CC4CC3C4)nc(N3C[C@@H]4C[C@H]3CO4)n2)nc1OC(F)F | Homo sapiens | CHEMBL5239394 | cell-based format |
| CHEMBL5277276 |  |
IC50 | = | 14.0 | nM | 375.38 | Nc1ncc(-c2cc(C3CC3)nc(N3C[C@@H]4C[C@H]3CO4)c2)nc1OC(F)F | Homo sapiens | CHEMBL5239394 | cell-based format |
| CHEMBL5284890 |  |
IC50 | = | 17.0 | nM | 441.39 | Nc1ncc(-c2cc(N3CCC(F)(F)C3)nc(N3C[C@@H]4C[C@H]3CO4)n2)nc1OC(F)F | Homo sapiens | CHEMBL5239394 | cell-based format |
| CHEMBL5420393 |  |
IC50 | = | 19.0 | nM | 467.49 | CC(C)[C@H](O)c1nc(-c2cnc(N)c(OC(F)(F)F)c2)cn1C12CC(N3CCOCC3)(C1)C2 | Homo sapiens | CHEMBL5335424 | cell-based format |
| CHEMBL5278185 |  |
IC50 | = | 24.0 | nM | 376.37 | Nc1ncc(-c2cc(C3CC3)nc(N3C[C@@H]4C[C@H]3CO4)n2)nc1OC(F)F | Homo sapiens | CHEMBL5239394 | cell-based format |
| CHEMBL5269484 |  |
IC50 | = | 28.0 | nM | 375.38 | Nc1ncc(-c2cc(C3CC3)cc(N3C[C@@H]4C[C@H]3CO4)n2)nc1OC(F)F | Homo sapiens | CHEMBL5239394 | cell-based format |
| CHEMBL3393333 |  |
IC50 | = | 30.0 | nM | 440.5 | N#Cc1ccnc(Nc2cc(C3CCN(C4COC4)CC3)cc(N3CCC(F)(F)C3)n2)c1 | Homo sapiens | CHEMBL3395586 | cell-based format |