Q12797 | ASPH_HUMAN | Aspartyl/asparaginyl beta-hydroxylase (ASPH)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF05118 | Asp_Arg_Hydrox - Aspartyl/Asparaginyl beta-hydroxylase | 591~745 | |
| PF05279 | Asp-B-Hydro_N - Aspartyl beta-hydroxylase N-terminal region | 43~108 | |
| PF13432 | TPR_16 - Tetratricopeptide repeat | 345~385 |
3D structures mapped by conservation among orthologs
[ Domain: "Double-stranded beta-helix" // Asp_Arg_Hydrox ]
[ Domain: "ARM repeat" // TPR_11_6 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL316034 |  |
IC50 | = | 20.0 | nM | 167.12 | O=C(O)c1ccnc(C(=O)O)c1 | Homo sapiens | CHEMBL4672388 | assay format |
| CHEMBL5422782 |  |
IC50 | = | 50.0 | nM | 185.11 | O=C(O)c1cc(C(=O)O)c(F)cn1 | Homo sapiens | CHEMBL5364263 | single protein format |
| CHEMBL5430087 |  |
IC50 | = | 110.0 | nM | 185.11 | O=C(O)c1ccnc(C(=O)O)c1F | Homo sapiens | CHEMBL5364263 | single protein format |
| CHEMBL51483 |  |
IC50 | = | 250.0 | nM | 518.56 | Cc1cc2c(C(C)C)c(O)c(O)c(C=O)c2c(O)c1-c1c(C)cc2c(C(C)C)c(O)c(O)c(C=O)c2c1O | Homo sapiens | CHEMBL4672388 | assay format |
| CHEMBL5429223 |  |
IC50 | = | 280.0 | nM | 286.29 | CC(Nc1c(C(=O)O)ccnc1C(=O)O)c1ccccc1 | Homo sapiens | CHEMBL5364262 | cell-based format |
| CHEMBL5425339 |  |
IC50 | = | 500.0 | nM | 272.26 | O=C(O)c1cc(C(=O)O)c(NCc2ccccc2)cn1 | Homo sapiens | CHEMBL5364265 | assay format |
| CHEMBL5415306 |  |
IC50 | = | 580.0 | nM | 302.29 | COc1ccc(CNc2c(C(=O)O)ccnc2C(=O)O)cc1 | Homo sapiens | CHEMBL5364262 | cell-based format |
| CHEMBL5428941 |  |
IC50 | = | 900.0 | nM | 302.29 | COc1ccccc1CNc1cnc(C(=O)O)cc1C(=O)O | Homo sapiens | CHEMBL5364265 | assay format |