Q12778 | FOXO1_HUMAN | Forkhead box protein O1 (FOXO1)
Helixβ‑strandTurn secondary structure
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00250 | Forkhead | 162–243 | |
| PF16675 | FOXO_KIX_bdg | 423–504 | |
| PF16676 | FOXO-TAD | 595–634 |
3D structures mapped by conservation among orthologs
[ Domain: "winged" // Forkhead ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5192734 |  |
IC50 | = | 33.0 | nM | 347.39 | CCn1cc(C(=O)O)c(=O)c2c(N)c(F)c(NC3CCCCC3)cc21 | Homo sapiens | CHEMBL5148216 | cell-based format |
| CHEMBL5399706 |  |
IC50 | <= | 50.0 | nM | 381.82 | CCOc1ccc(C(=O)Nc2cc(-c3nc4ccccc4[nH]3)n[nH]2)cc1Cl | Homo sapiens | CHEMBL5393541 | cell-based format |
| CHEMBL5402706 |  |
IC50 | <= | 50.0 | nM | 381.82 | COc1ccc(C(=O)Nc2cc(-c3nc4ccccc4[nH]3)n(C)n2)cc1Cl | Homo sapiens | CHEMBL5393541 | cell-based format |
| CHEMBL5435840 |  |
IC50 | <= | 50.0 | nM | 363.38 | COc1ccc(C(=O)Nc2cc(-c3nc4ccccc4[nH]3)n[nH]2)cc1OC | Homo sapiens | CHEMBL5393541 | cell-based format |
| CHEMBL5413797 |  |
IC50 | <= | 50.0 | nM | 386.46 | O=C(Nc1cc(-c2nc3ccccc3[nH]2)n[nH]1)c1ccc(N2CCCCC2)cc1 | Homo sapiens | CHEMBL5393541 | cell-based format |
| CHEMBL5395312 |  |
IC50 | <= | 50.0 | nM | 401.47 | CN1CCN(c2ccc(C(=O)Nc3cc(-c4nc5ccccc5[nH]4)n[nH]3)cc2)CC1 | Homo sapiens | CHEMBL5393541 | cell-based format |
| CHEMBL5429177 |  |
IC50 | <= | 50.0 | nM | 367.8 | COc1ccc(C(=O)Nc2cc(-c3nc4ccccc4[nH]3)n[nH]2)cc1Cl | Homo sapiens | CHEMBL5393541 | cell-based format |
| CHEMBL5410138 |  |
IC50 | <= | 50.0 | nM | 372.43 | O=C(Nc1cc(-c2nc3ccccc3[nH]2)[nH]n1)c1ccc(N2CCCC2)cc1 | Homo sapiens | CHEMBL5393541 | cell-based format |
| CHEMBL5402411 |  |
IC50 | <= | 50.0 | nM | 388.43 | O=C(Nc1cc(-c2nc3ccccc3[nH]2)[nH]n1)c1ccc(N2CCOCC2)cc1 | Homo sapiens | CHEMBL5393541 | cell-based format |
| CHEMBL5409852 |  |
IC50 | <= | 50.0 | nM | 380.84 | CN(C)c1ccc(C(=O)Nc2cc(-c3nc4ccccc4[nH]3)[nH]n2)cc1Cl | Homo sapiens | CHEMBL5393541 | cell-based format |
| CHEMBL5407932 |  |
IC50 | <= | 50.0 | nM | 374.45 | CCN(CC)c1ccc(C(=O)Nc2cc(-c3nc4ccccc4[nH]3)[nH]n2)cc1 | Homo sapiens | CHEMBL5393541 | cell-based format |
| CHEMBL5426417 |  |
IC50 | <= | 50.0 | nM | 402.24 | COc1ccc(C(=O)Nc2cc(-c3nc4cc(Cl)ccc4[nH]3)[nH]n2)cc1Cl | Homo sapiens | CHEMBL5393541 | cell-based format |
| CHEMBL5418339 |  |
IC50 | <= | 50.0 | nM | 397.82 | COc1ccc2[nH]c(-c3cc(NC(=O)c4ccc(OC)c(Cl)c4)n[nH]3)nc2c1 | Homo sapiens | CHEMBL5393541 | cell-based format |
| CHEMBL5406512 |  |
IC50 | <= | 50.0 | nM | 346.39 | CN(C)c1ccc(C(=O)Nc2cc(-c3nc4ccccc4[nH]3)n[nH]2)cc1 | Homo sapiens | CHEMBL5393541 | cell-based format |
| CHEMBL5399112 |  |
IC50 | <= | 1000.0 | nM | 387.45 | O=C(Nc1cc(-c2nc3ccccc3[nH]2)n[nH]1)c1ccc(N2CCNCC2)cc1 | Homo sapiens | CHEMBL5393541 | cell-based format |
| CHEMBL5428094 |  |
IC50 | <= | 1000.0 | nM | 364.38 | CN(C)c1ccc(C(=O)Nc2cc(-c3nc4ccccc4[nH]3)[nH]n2)cc1F | Homo sapiens | CHEMBL5393541 | cell-based format |
| CHEMBL5431330 |  |
IC50 | <= | 1000.0 | nM | 349.35 | COc1ccc(C(=O)Nc2cc(-c3nc4ccccc4[nH]3)n[nH]2)cc1O | Homo sapiens | CHEMBL5393541 | cell-based format |
| CHEMBL5401447 |  |
IC50 | <= | 1000.0 | nM | 347.33 | O=C(Nc1cc(-c2nc3ccccc3[nH]2)n[nH]1)c1ccc2c(c1)OCO2 | Homo sapiens | CHEMBL5393541 | cell-based format |
| CHEMBL5395969 |  |
IC50 | <= | 1000.0 | nM | 345.36 | O=C(Nc1cc(-c2nc3ccccc3[nH]2)n[nH]1)c1ccc2c(c1)CCO2 | Homo sapiens | CHEMBL5393541 | cell-based format |
| CHEMBL5407275 |  |
IC50 | <= | 1000.0 | nM | 402.24 | COc1ccc(C(=O)Nc2cc(-c3nc4c(Cl)cccc4[nH]3)[nH]n2)cc1Cl | Homo sapiens | CHEMBL5393541 | cell-based format |