Q09472 | EP300_HUMAN | Histone acetyltransferase p300 (EP300)

Pfam Domain Table

AccessionDomainRangeColor
PF00439Bromodomain - Bromodomain1068~1143
PF00569ZZ - Zinc finger, ZZ type1665~1705
PF02135zf-TAZ - TAZ zinc finger338~414
PF02135zf-TAZ - TAZ zinc finger1735~1806
PF02172KIX - KIX domain567~646
PF06001RING_CBP-p300 - CREB-binding protein/p300, atypical RING domain1156~1195
PF08214HAT_KAT11 - Histone acetylation protein1306~1611
PF09030Creb_binding - Creb binding1992~2098
PF23570PHD_P300 - Histone acetyltransferase p300-like, PHD domain1240~1278

3D structures mapped by conservation among orthologs

[ Domain: "Bromodomain" // Bromodomain ]

 PyMOL session

[ Domain: "Acyl-CoA N-acyltransferases (Nat)" // HAT_KAT11 ]

 PyMOL session

[ Domain: "TAZ domain" // zf-TAZ ]

 PyMOL session

[ Domain: "RING/U-box" // ZZ ]

 PyMOL session

[ Domain: "RING/U-box" // DUF902 ]

 PyMOL session

[ Domain: "FYVE/PHD zinc finger" // PHD_CBP ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL5090239 IC50 = 0.49 nM 522.53 CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3cc(F)ccc3OC[C@H]2C2CC2)C1=O Homo sapiens CHEMBL5033899 single protein format
CHEMBL5082755 IC50 = 0.56 nM 538.55 CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3cc(F)c(F)cc3CC[C@H]2C2CC2)C1=O Homo sapiens CHEMBL5033899 single protein format
CHEMBL4475351 IC50 = 1.1 nM 520.56 CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccc(F)cc3CC[C@H]2C2CC2)C1=O Homo sapiens CHEMBL4325427 single protein format
CHEMBL4097025 IC50 = 1.2 nM 525.6 CNC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCOCC2)C1 Homo sapiens CHEMBL4058605 single protein format
CHEMBL4567310 IC50 = 1.3 nM 529.57 Cn1cc(-c2ccc3c(c2)CC[C@]32NC(=O)N(CC(=O)N3Cc4cc(F)ccc4OC[C@H]3C3CC3)C2=O)cn1 Homo sapiens CHEMBL4325427 single protein format
CHEMBL4076748 IC50 = 1.3 nM 510.59 CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCOCC2)C1 Homo sapiens CHEMBL4058605 single protein format
CHEMBL5083020 IC50 = 1.7 nM 538.55 CNC(=O)Nc1cc2c(cc1F)[C@@]1(CC2)OC(=O)N(CC(=O)N2Cc3ccc(F)cc3CC[C@H]2C2CC2)C1=O Homo sapiens CHEMBL5033899 single protein format
CHEMBL4587968 IC50 = 1.8 nM 557.5 Cn1cc(-c2ccc3c(c2)CC[C@]32NC(=O)N(CC(=O)N3Cc4cc(F)ccc4OC[C@H]3C(F)(F)F)C2=O)cn1 Homo sapiens CHEMBL4325427 single protein format
CHEMBL4457144 IC50 = 1.9 nM 548.49 CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccc(F)cc3CC[C@H]2C(F)(F)F)C1=O Homo sapiens CHEMBL4325427 single protein format
CHEMBL5077158 IC50 = 2.2 nM 534.59 CNC(=O)Nc1ccc2c(c1)CCC[C@@]21OC(=O)N(CC(=O)N2Cc3ccc(F)cc3CC[C@H]2C2CC2)C1=O Homo sapiens CHEMBL5033899 single protein format
CHEMBL4464962 IC50 = 2.4 nM 550.47 CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3cc(F)ccc3OC[C@H]2C(F)(F)F)C1=O Homo sapiens CHEMBL4325427 single protein format
CHEMBL4450724 IC50 = 2.4 nM 558.49 Cn1cc(-c2ccc3c(c2)CC[C@@]32OC(=O)N(CC(=O)N3Cc4cc(F)ccc4OC[C@H]3C(F)(F)F)C2=O)cn1 Homo sapiens CHEMBL4325427 single protein format
CHEMBL4449592 IC50 = 2.6 nM 530.5 CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccccc3CC[C@H]2C(F)(F)F)C1=O Homo sapiens CHEMBL4325427 single protein format
CHEMBL4452911 IC50 = 3.0 nM 494.52 CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccc(F)cc3CC[C@H]2C)C1=O Homo sapiens CHEMBL4325427 single protein format
CHEMBL4552724 IC50 = 3.7 nM 502.57 CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccccc3CC[C@H]2C2CC2)C1=O Homo sapiens CHEMBL4325427 single protein format
CHEMBL4474109 IC50 = 4.0 nM 530.56 Cn1cc(-c2ccc3c(c2)CC[C@@]32OC(=O)N(CC(=O)N3Cc4cc(F)ccc4OC[C@H]3C3CC3)C2=O)cn1 Homo sapiens CHEMBL4325427 single protein format
CHEMBL5094423 IC50 = 4.0 nM 510.57 CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3sccc3OC[C@H]2C2CC2)C1=O Homo sapiens CHEMBL5033899 single protein format
CHEMBL4474031 IC50 = 4.0 nM 504.59 CCC[C@@H]1CCc2ccccc2CN1C(=O)CN1C(=O)O[C@@]2(CCc3cc(NC(=O)NC)ccc32)C1=O Homo sapiens CHEMBL4325427 single protein format
CHEMBL4449940 IC50 = 4.2 nM 521.55 CNC(=O)Nc1ccc2c(c1)CC[C@]21NC(=O)N(CC(=O)N2Cc3cc(F)ccc3OC[C@H]2C2CC2)C1=O Homo sapiens CHEMBL4325427 single protein format
CHEMBL4593536 IC50 = 4.3 nM 504.59 CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccccc3CC[C@H]2C(C)C)C1=O Homo sapiens CHEMBL4325427 single protein format