Q09428 | ABCC8_HUMAN | ATP-binding cassette sub-family C member 8 (ABCC8)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00005 | ABC_tran - ABC transporter | 696~856 | |
| PF00005 | ABC_tran - ABC transporter | 1361~1509 | |
| PF00664 | ABC_membrane - ABC transporter transmembrane region | 304~590 | |
| PF00664 | ABC_membrane - ABC transporter transmembrane region | 1014~1292 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1272 |  |
IC50 | = | 106.0 | nM | 452.6 | CCOc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N2CCCCC2)ccc1C(=O)O | Homo sapiens | CHEMBL832318 | cell-based format |
| CHEMBL360610 |  |
IC50 | = | 163.0 | nM | 438.57 | COc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N2CCCCC2)ccc1C(=O)O | Homo sapiens | CHEMBL832318 | cell-based format |
| CHEMBL186684 |  |
IC50 | = | 281.0 | nM | 470.59 | CC(C)C[C@H](NC(=O)Cc1ccc(C(=O)O)c(OCCF)c1)c1ccccc1N1CCCCC1 | Homo sapiens | CHEMBL832318 | cell-based format |