Q08828 | ADCY1_HUMAN | Adenylate cyclase type 1 (ADCY1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00211 | Guanylate_cyc - Adenylate and Guanylate cyclase catalytic domain | 294~476 | |
| PF00211 | Guanylate_cyc - Adenylate and Guanylate cyclase catalytic domain | 860~1056 | |
| PF16214 | AC_N - Adenylyl cyclase N-terminal extracellular and transmembrane region | 40~283 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL328689 |  |
IC50 | = | 21.0 | nM | 558.67 | C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](OC(=O)NCCc3ccccn3)[C@H](OC(C)=O)[C@@]2(C)O1 | Homo sapiens | CHEMBL645668 | assay format |
| CHEMBL328561 |  |
IC50 | = | 31.0 | nM | 496.6 | C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](OC(=O)NCCN)[C@H](OC(C)=O)[C@@]2(C)O1 | Homo sapiens | CHEMBL645668 | assay format |
| CHEMBL92229 |  |
IC50 | = | 32.0 | nM | 511.61 | C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](OC(=O)NCCOC)[C@H](OC(C)=O)[C@@]2(C)O1 | Homo sapiens | CHEMBL645668 | assay format |
| CHEMBL329247 |  |
IC50 | = | 36.0 | nM | 557.68 | C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](OC(=O)NCCc3ccccc3)[C@H](OC(C)=O)[C@@]2(C)O1 | Homo sapiens | CHEMBL645668 | assay format |
| CHEMBL93009 |  |
IC50 | = | 39.0 | nM | 572.7 | C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](OC(=O)NCCc3ccc(N)cc3)[C@H](OC(C)=O)[C@@]2(C)O1 | Homo sapiens | CHEMBL645668 | assay format |
| CHEMBL52606 |  |
IC50 | = | 41.0 | nM | 410.51 | C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](O)[C@H](OC(C)=O)[C@@]2(C)O1 | Homo sapiens | CHEMBL645668 | assay format |
| CHEMBL317990 |  |
IC50 | = | 43.0 | nM | 455.55 | C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](O)[C@H](OC(=O)NCCO)[C@@]2(C)O1 | Homo sapiens | CHEMBL645668 | assay format |
| CHEMBL432817 |  |
IC50 | = | 44.0 | nM | 553.65 | C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](OC(=O)NCCC(=O)OCC)[C@H](OC(C)=O)[C@@]2(C)O1 | Homo sapiens | CHEMBL645668 | assay format |
| CHEMBL93242 |  |
IC50 | = | 64.0 | nM | 530.66 | C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](O)[C@H](OC(=O)NCCc3ccc(N)cc3)[C@@]2(C)O1 | Homo sapiens | CHEMBL645668 | assay format |
| CHEMBL93259 |  |
IC50 | = | 65.0 | nM | 515.65 | C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](OC(=O)NCCc3ccccc3)[C@H](O)[C@@]2(C)O1 | Homo sapiens | CHEMBL645668 | assay format |
| CHEMBL92911 |  |
IC50 | = | 73.0 | nM | 524.66 | C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](OC(=O)NCCN(C)C)[C@H](OC(C)=O)[C@@]2(C)O1 | Homo sapiens | CHEMBL645668 | assay format |
| CHEMBL329916 |  |
IC50 | = | 76.0 | nM | 495.61 | C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](OC(=O)NCCC)[C@H](OC(C)=O)[C@@]2(C)O1 | Homo sapiens | CHEMBL645668 | assay format |
| CHEMBL328358 |  |
IC50 | = | 76.0 | nM | 493.6 | C=CCNC(=O)O[C@H]1[C@H]2C(C)(C)CC[C@H](O)[C@]2(C)[C@@]2(O)C(=O)C[C@](C)(C=C)O[C@]2(C)[C@H]1OC(C)=O | Homo sapiens | CHEMBL645668 | assay format |
| CHEMBL430458 |  |
IC50 | = | 82.0 | nM | 564.72 | C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](OC(=O)NCCN3CCCCC3)[C@H](OC(C)=O)[C@@]2(C)O1 | Homo sapiens | CHEMBL645668 | assay format |
| CHEMBL93521 |  |
IC50 | = | 89.0 | nM | 453.58 | C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](O)[C@H](OC(=O)NCCC)[C@@]2(C)O1 | Homo sapiens | CHEMBL645668 | assay format |
| CHEMBL327672 |  |
IC50 | = | 95.0 | nM | 531.65 | C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](O)[C@H](OC(=O)NCCc3ccc(O)cc3)[C@@]2(C)O1 | Homo sapiens | CHEMBL645668 | assay format |
| CHEMBL93260 |  |
IC50 | = | 112.0 | nM | 467.6 | C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](O)[C@H](OC(=O)NCC(C)C)[C@@]2(C)O1 | Homo sapiens | CHEMBL645668 | assay format |
| CHEMBL94343 |  |
IC50 | = | 117.0 | nM | 516.64 | C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](OC(=O)NCCc3ccccn3)[C@H](O)[C@@]2(C)O1 | Homo sapiens | CHEMBL645668 | assay format |
| CHEMBL92577 |  |
IC50 | = | 117.0 | nM | 549.71 | C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](OC(=O)NCC3CCCCC3)[C@H](OC(C)=O)[C@@]2(C)O1 | Homo sapiens | CHEMBL645668 | assay format |
| CHEMBL94313 |  |
IC50 | = | 123.0 | nM | 522.68 | C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](OC(=O)NCCN3CCCCC3)[C@H](O)[C@@]2(C)O1 | Homo sapiens | CHEMBL645668 | assay format |