Q08493 | PDE4C_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4C (PDE4C)
Pfam Domain Table
Accession | Domain | Range | Color |
---|---|---|---|
PF00233 | PDEase_I - 3'5'-cyclic nucleotide phosphodiesterase | 387~626 | |
PF18100 | PDE4_UCR - Phosphodiesterase 4 upstream conserved regions (UCR) | 152~268 |
3D structures mapped by conservation among orthologs
[ Domain: "HD-domain/PDEase-like" // PDEase_I ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
---|---|---|---|---|---|---|---|---|---|---|
CHEMBL380321 | IC50 | = | 0.05 | nM | 574.71 | CC(C)(C#N)c1cc(-c2cccc(CN(C(=O)Nc3ccccc3)c3ccc(S(C)(=O)=O)cc3)c2)c2ncccc2c1 | Homo sapiens | CHEMBL866913 | single protein format | |
CHEMBL197392 | IC50 | = | 0.4 | nM | 518.68 | Cc1ccc(/C(=C/c2cccc(-c3cc(C(C)C)cc4cccnc34)c2)c2ccc(S(C)(=O)=O)cc2)nc1 | Homo sapiens | CHEMBL860121 | single protein format | |
CHEMBL198674 | IC50 | = | 0.5 | nM | 561.75 | CC(C)c1cc(-c2cccc(/C=C(/c3ccc(C(C)(C)O)cc3)c3ccc(S(C)(=O)=O)cc3)c2)c2ncccc2c1 | Homo sapiens | CHEMBL860121 | single protein format | |
CHEMBL196969 | IC50 | = | 0.7 | nM | 510.68 | CC(C)c1cc(-c2cccc(/C=C(\c3ccc(S(C)(=O)=O)cc3)c3nccs3)c2)c2ncccc2c1 | Homo sapiens | CHEMBL860121 | single protein format | |
CHEMBL206968 | IC50 | = | 0.9 | nM | 564.67 | Cc1cc(C(=O)N(Cc2cccc(-c3cc(C(C)(C)C#N)cc4cccnc34)c2)c2ccc(S(C)(=O)=O)cc2)no1 | Homo sapiens | CHEMBL866913 | single protein format | |
CHEMBL383225 | IC50 | = | 1.0 | nM | 559.69 | CC(C)(C#N)c1cc(-c2cccc(CN(C(=O)c3ccccc3)c3ccc(S(C)(=O)=O)cc3)c2)c2ncccc2c1 | Homo sapiens | CHEMBL866913 | single protein format | |
CHEMBL199015 | IC50 | = | 1.0 | nM | 570.46 | [O-][n+]1cccc(C[C@@H](c2ccc(OC(F)F)c(OC3CC3)c2)c2cnc(C(O)(C(F)(F)F)C(F)(F)F)s2)c1 | Homo sapiens | CHEMBL860121 | single protein format | |
CHEMBL381681 | IC50 | = | 1.2 | nM | 509.63 | Cc1noc(/C(=C/c2cccc(-c3cc(C(C)C)cc4cccnc34)c2)c2ccc(S(C)(=O)=O)cc2)n1 | Homo sapiens | CHEMBL860121 | single protein format | |
CHEMBL77826 | IC50 | = | 1.23 | nM | 368.35 | O=C(O)c1ccc(-c2cc3cccnc3c(-c3ccc4nonc4c3)n2)cc1 | Homo sapiens | CHEMBL5236726 | single protein format | |
CHEMBL377709 | IC50 | = | 1.7 | nM | 593.77 | CC(C)NC(=O)N(Cc1cccc(-c2cc(C(C)(C)S(C)(=O)=O)cc3cccnc23)c1)c1ccc(S(C)(=O)=O)cc1 | Homo sapiens | CHEMBL866913 | single protein format | |
CHEMBL193240 | IC50 | = | 1.7 | nM | 403.21 | O=C(Nc1c(Cl)cncc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 | Homo sapiens | CHEMBL4709037 | single protein format | |
CHEMBL382168 | IC50 | = | 1.7 | nM | 540.69 | CC(C)NC(=O)N(Cc1cccc(-c2cc(C(C)(C)C#N)cc3cccnc23)c1)c1ccc(S(C)(=O)=O)cc1 | Homo sapiens | CHEMBL866913 | single protein format | |
CHEMBL5193314 | IC50 | = | 2.1 | nM | 354.17 | CC(C)OCCOc1ncc(Oc2ccc3c(c2)B(O)OC3)cc1C#N | Homo sapiens | CHEMBL5105238 | single protein format | |
CHEMBL371089 | IC50 | = | 2.9 | nM | 512.68 | CC(C)NC(=O)/C(=C/c1cccc(-c2cc(C(C)C)cc3cccnc23)c1)c1ccc(S(C)(=O)=O)cc1 | Homo sapiens | CHEMBL860121 | single protein format | |
CHEMBL4747201 | IC50 | = | 3.0 | nM | 421.45 | COc1ccc(-c2ccc3c(c2)COC3=O)n2nc(C3(C(=O)OCC(C)C)CC3)nc12 | Homo sapiens | CHEMBL4676345 | single protein format | |
CHEMBL198432 | IC50 | = | 3.3 | nM | 326.4 | COc1cccc(-c2cc(Cc3ccncc3)cc3cccnc23)c1 | Homo sapiens | CHEMBL860121 | single protein format | |
CHEMBL197386 | IC50 | = | 3.8 | nM | 471.58 | CC(C)c1cc(-c2cccc(/C=C(/C(=O)O)c3ccc(S(C)(=O)=O)cc3)c2)c2ncccc2c1 | Homo sapiens | CHEMBL860121 | single protein format | |
CHEMBL42126 | IC50 | = | 3.8 | nM | 381.26 | COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)cc1OC1CCCC1 | Homo sapiens | CHEMBL761822 | single protein format | |
CHEMBL209295 | IC50 | = | 4.2 | nM | 541.67 | CC(C)OC(=O)N(Cc1cccc(-c2cc(C(C)(C)C#N)cc3cccnc23)c1)c1ccc(S(C)(=O)=O)cc1 | Homo sapiens | CHEMBL866913 | single protein format | |
CHEMBL32442 | IC50 | = | 4.5 | nM | 373.5 | COc1ccc([C@H](Cc2ccncc2)c2ccccc2)cc1OC1CCCC1 | Homo sapiens | CHEMBL860121 | single protein format |