Q08493 | PDE4C_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4C (PDE4C)

Pfam Domain Table

AccessionDomainRangeColor
PF00233PDEase_I - 3'5'-cyclic nucleotide phosphodiesterase387~626
PF18100PDE4_UCR - Phosphodiesterase 4 upstream conserved regions (UCR)152~268

3D structures mapped by conservation among orthologs

[ Domain: "HD-domain/PDEase-like" // PDEase_I ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL380321 IC50 = 0.05 nM 574.71 CC(C)(C#N)c1cc(-c2cccc(CN(C(=O)Nc3ccccc3)c3ccc(S(C)(=O)=O)cc3)c2)c2ncccc2c1 Homo sapiens CHEMBL866913 single protein format
CHEMBL197392 IC50 = 0.4 nM 518.68 Cc1ccc(/C(=C/c2cccc(-c3cc(C(C)C)cc4cccnc34)c2)c2ccc(S(C)(=O)=O)cc2)nc1 Homo sapiens CHEMBL860121 single protein format
CHEMBL198674 IC50 = 0.5 nM 561.75 CC(C)c1cc(-c2cccc(/C=C(/c3ccc(C(C)(C)O)cc3)c3ccc(S(C)(=O)=O)cc3)c2)c2ncccc2c1 Homo sapiens CHEMBL860121 single protein format
CHEMBL196969 IC50 = 0.7 nM 510.68 CC(C)c1cc(-c2cccc(/C=C(\c3ccc(S(C)(=O)=O)cc3)c3nccs3)c2)c2ncccc2c1 Homo sapiens CHEMBL860121 single protein format
CHEMBL206968 IC50 = 0.9 nM 564.67 Cc1cc(C(=O)N(Cc2cccc(-c3cc(C(C)(C)C#N)cc4cccnc34)c2)c2ccc(S(C)(=O)=O)cc2)no1 Homo sapiens CHEMBL866913 single protein format
CHEMBL383225 IC50 = 1.0 nM 559.69 CC(C)(C#N)c1cc(-c2cccc(CN(C(=O)c3ccccc3)c3ccc(S(C)(=O)=O)cc3)c2)c2ncccc2c1 Homo sapiens CHEMBL866913 single protein format
CHEMBL199015 IC50 = 1.0 nM 570.46 [O-][n+]1cccc(C[C@@H](c2ccc(OC(F)F)c(OC3CC3)c2)c2cnc(C(O)(C(F)(F)F)C(F)(F)F)s2)c1 Homo sapiens CHEMBL860121 single protein format
CHEMBL381681 IC50 = 1.2 nM 509.63 Cc1noc(/C(=C/c2cccc(-c3cc(C(C)C)cc4cccnc34)c2)c2ccc(S(C)(=O)=O)cc2)n1 Homo sapiens CHEMBL860121 single protein format
CHEMBL77826 IC50 = 1.23 nM 368.35 O=C(O)c1ccc(-c2cc3cccnc3c(-c3ccc4nonc4c3)n2)cc1 Homo sapiens CHEMBL5236726 single protein format
CHEMBL377709 IC50 = 1.7 nM 593.77 CC(C)NC(=O)N(Cc1cccc(-c2cc(C(C)(C)S(C)(=O)=O)cc3cccnc23)c1)c1ccc(S(C)(=O)=O)cc1 Homo sapiens CHEMBL866913 single protein format
CHEMBL193240 IC50 = 1.7 nM 403.21 O=C(Nc1c(Cl)cncc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 Homo sapiens CHEMBL4709037 single protein format
CHEMBL382168 IC50 = 1.7 nM 540.69 CC(C)NC(=O)N(Cc1cccc(-c2cc(C(C)(C)C#N)cc3cccnc23)c1)c1ccc(S(C)(=O)=O)cc1 Homo sapiens CHEMBL866913 single protein format
CHEMBL5193314 IC50 = 2.1 nM 354.17 CC(C)OCCOc1ncc(Oc2ccc3c(c2)B(O)OC3)cc1C#N Homo sapiens CHEMBL5105238 single protein format
CHEMBL371089 IC50 = 2.9 nM 512.68 CC(C)NC(=O)/C(=C/c1cccc(-c2cc(C(C)C)cc3cccnc23)c1)c1ccc(S(C)(=O)=O)cc1 Homo sapiens CHEMBL860121 single protein format
CHEMBL4747201 IC50 = 3.0 nM 421.45 COc1ccc(-c2ccc3c(c2)COC3=O)n2nc(C3(C(=O)OCC(C)C)CC3)nc12 Homo sapiens CHEMBL4676345 single protein format
CHEMBL198432 IC50 = 3.3 nM 326.4 COc1cccc(-c2cc(Cc3ccncc3)cc3cccnc23)c1 Homo sapiens CHEMBL860121 single protein format
CHEMBL197386 IC50 = 3.8 nM 471.58 CC(C)c1cc(-c2cccc(/C=C(/C(=O)O)c3ccc(S(C)(=O)=O)cc3)c2)c2ncccc2c1 Homo sapiens CHEMBL860121 single protein format
CHEMBL42126 IC50 = 3.8 nM 381.26 COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)cc1OC1CCCC1 Homo sapiens CHEMBL761822 single protein format
CHEMBL209295 IC50 = 4.2 nM 541.67 CC(C)OC(=O)N(Cc1cccc(-c2cc(C(C)(C)C#N)cc3cccnc23)c1)c1ccc(S(C)(=O)=O)cc1 Homo sapiens CHEMBL866913 single protein format
CHEMBL32442 IC50 = 4.5 nM 373.5 COc1ccc([C@H](Cc2ccncc2)c2ccccc2)cc1OC1CCCC1 Homo sapiens CHEMBL860121 single protein format