Q07973 | CP24A_HUMAN | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00067 | p450 - Cytochrome P450 | 59~503 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL389433 |  |
IC50 | = | 2.3 | nM | 308.77 | Clc1cccc(C(c2ccc3[nH]cnc3c2)n2ccnc2)c1 | Homo sapiens | CHEMBL3369890 | assay format |
| CHEMBL389014 |  |
IC50 | = | 7.4 | nM | 483.72 | C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCS(=N)(=O)c4ccccc4)CC[C@@H]23)C[C@@H](O)C[C@@H]1O | Homo sapiens | CHEMBL917755 | cell-based format |
| CHEMBL255088 |  |
IC50 | = | 7.4 | nM | 481.7 | C=C1/C(=C\C=C2/CCC[C@]3(C)C([C@H](C)CC[S+](=N)([O-])c4ccccc4)=CCC23)C[C@@H](O)C[C@@H]1O | Homo sapiens | CHEMBL926260 | single protein format |
| CHEMBL1627206 |  |
IC50 | = | 9.7 | nM | 471.71 | C[C@H](CC[S+](=N)([O-])c1ccccc1)[C@H]1CC[C@H]2/C(=C/C=C3C[C@@H](O)C[C@H](O)C3)CCC[C@]12C | Homo sapiens | CHEMBL917755 | cell-based format |
| CHEMBL1170908 |  |
IC50 | = | 15.0 | nM | 401.9 | O=C(NC[C@@H](c1ccccc1)n1ccnc1)c1ccc(-c2ccc(Cl)cc2)cc1 | Homo sapiens | CHEMBL3369890 | assay format |
| CHEMBL253613 |  |
IC50 | = | 15.0 | nM | 401.9 | O=C(NCC(c1ccccc1)n1ccnc1)c1ccc(-c2ccc(Cl)cc2)cc1 | Homo sapiens | CHEMBL926258 | cell-based format |
| CHEMBL2105705 |  |
IC50 | = | 27.0 | nM | 474.71 | C=C1/C(=C\C=C2/CCC[C@]3(C)C([C@H](C)C/C=C/S(=O)(=O)C(C)(C)C)=CC[C@@H]23)C[C@@H](O)C[C@@H]1O | Homo sapiens | CHEMBL3369890 | assay format |
| CHEMBL4797263 |  |
IC50 | = | 27.0 | nM | 460.68 | C=C1/C(=C\C=C2/CCC[C@]3(C)C([C@H](C)/C=C/S(=O)(=O)C(C)(C)C)=CC[C@@H]23)C[C@@H](O)C[C@@H]1O | Homo sapiens | CHEMBL4709773 | cell-based format |
| CHEMBL224719 |  |
IC50 | = | 28.0 | nM | 484.7 | C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCS(=O)(=O)c4ccccc4)CC[C@@H]23)C[C@@H](O)C[C@@H]1O | Homo sapiens | CHEMBL917755 | cell-based format |
| CHEMBL1627207 |  |
IC50 | = | 44.0 | nM | 501.71 | C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CC[S+](=N)([O-])c4ccc(F)cc4)CC[C@@H]23)C[C@@H](O)C[C@@H]1O | Homo sapiens | CHEMBL917755 | cell-based format |
| CHEMBL1627203 |  |
IC50 | = | 50.0 | nM | 509.76 | C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CC4([S+](=N)([O-])c5ccccc5)CC4)CC[C@@H]23)C[C@@H](O)C[C@@H]1O | Homo sapiens | CHEMBL917755 | cell-based format |
| CHEMBL1627204 |  |
IC50 | = | 75.0 | nM | 467.72 | C=C1CC[C@H](O)C/C1=C/C=C1\CCC[C@]2(C)[C@@H]([C@H](C)CC[S+](=N)([O-])c3ccccc3)CC[C@@H]12 | Homo sapiens | CHEMBL917755 | cell-based format |
| CHEMBL3329769 |  |
IC50 | = | 110.0 | nM | 453.54 | COc1cc(/C=C/c2ccc(C(=O)NCC(c3ccccc3)n3ccnc3)cc2)cc(OC)c1 | Homo sapiens | CHEMBL3369890 | assay format |
| CHEMBL4105510 |  |
IC50 | = | 110.0 | nM | 423.52 | COc1ccc(C(CNC(=O)c2ccc(/C=C/c3ccccc3)cc2)n2ccnc2)cc1 | Homo sapiens | CHEMBL4055735 | single protein format |
| CHEMBL4080128 |  |
IC50 | = | 120.0 | nM | 487.99 | COc1ccc(/C=C/c2ccc(C(=O)NCC(c3ccc(Cl)cc3)n3ccnc3)cc2)cc1OC | Homo sapiens | CHEMBL4055735 | single protein format |
| CHEMBL3329770 |  |
IC50 | = | 140.0 | nM | 483.57 | COc1cc(/C=C/c2ccc(C(=O)NCC(c3ccccc3)n3ccnc3)cc2)cc(OC)c1OC | Homo sapiens | CHEMBL3369890 | assay format |
| CHEMBL4066700 |  |
IC50 | = | 150.0 | nM | 461.49 | O=C(NCC(c1ccc(C(F)(F)F)cc1)n1ccnc1)c1cccc(/C=C/c2ccccc2)c1 | Homo sapiens | CHEMBL4055735 | single protein format |
| CHEMBL4087998 |  |
IC50 | = | 160.0 | nM | 427.94 | O=C(NCC(c1ccc(Cl)cc1)n1ccnc1)c1cccc(/C=C/c2ccccc2)c1 | Homo sapiens | CHEMBL4055735 | single protein format |
| CHEMBL3329774 |  |
IC50 | = | 160.0 | nM | 448.56 | COc1cc(/C=C/c2ccc(CCC(OC(=O)n3ccnc3)C(C)(C)C)cc2)cc(OC)c1 | Homo sapiens | CHEMBL3369890 | assay format |
| CHEMBL3329778 |  |
IC50 | = | 180.0 | nM | 356.47 | CC(C)(C)C(=O)/C(=C/c1ccc(/C=C/c2ccccc2)cc1)n1ccnc1 | Homo sapiens | CHEMBL3369890 | assay format |