Q07912 | ACK1_HUMAN | Activated CDC42 kinase 1 (TNK2)

Pfam Domain Table

AccessionDomainRangeColor
PF07714PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase127~384
PF09027GTPase_binding - GTPase binding450~513
PF11555Inhibitor_Mig-6 - EGFR receptor inhibitor Mig-6775~837
PF14604SH3_9 - Variant SH3 domain395~444
PF22931SAM_TNK - SAM domain-like10~65

3D structures mapped by conservation among orthologs

[ Domain: "SH3" // SH3_1 ]

 PyMOL session

[ Domain: "Protein kinase" // Pkinase_Tyr ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL5400397 IC50 = 0.2 nM 573.14 Cc1cc(Nc2ncc3cc(-c4ccccc4Cl)c(=O)n(C[C@H]4CCCO4)c3n2)ccc1N1CCC(N(C)C)CC1 Homo sapiens CHEMBL5341436 cell-based format
CHEMBL5431206 IC50 = 0.3 nM 561.09 COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2cc(-c3ccccc3Cl)c(=O)n(C[C@H]3CCCO3)c2n1 Homo sapiens CHEMBL5341436 cell-based format
CHEMBL5409024 IC50 = 0.4 nM 545.09 Cc1cc(Nc2ncc3cc(-c4ccccc4Cl)c(=O)n(C[C@H]4CCCO4)c3n2)ccc1N1CCN(C)CC1 Homo sapiens CHEMBL5341436 cell-based format
CHEMBL5398945 IC50 = 0.6 nM 524.67 Cc1ccccc1-c1cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc2n(C[C@H]2CCCO2)c1=O Homo sapiens CHEMBL5341436 cell-based format
CHEMBL5428907 IC50 = 0.6 nM 575.11 CCOc1cc(Nc2ncc3cc(-c4ccccc4Cl)c(=O)n(C[C@H]4CCCO4)c3n2)ccc1N1CCN(C)CC1 Homo sapiens CHEMBL5341436 cell-based format
CHEMBL5399309 IC50 = 0.7 nM 575.11 CCOc1cc(N2CCN(C)CC2)ccc1Nc1ncc2cc(-c3ccccc3Cl)c(=O)n(C[C@H]3CCCO3)c2n1 Homo sapiens CHEMBL5341436 cell-based format
CHEMBL5405674 IC50 = 0.7 nM 565.51 CN1CCN(c2ccc(Nc3ncc4cc(-c5ccccc5Cl)c(=O)n(C[C@H]5CCCO5)c4n3)cc2Cl)CC1 Homo sapiens CHEMBL5341436 cell-based format
CHEMBL5437496 IC50 = 0.8 nM 575.11 Cc1cc(Nc2ncc3cc(-c4ccccc4Cl)c(=O)n(C[C@H]4CCCO4)c3n2)ccc1N1CCN(CCO)CC1 Homo sapiens CHEMBL5341436 cell-based format
CHEMBL5436567 IC50 = 1.0 nM 589.14 CC(C)Oc1cc(Nc2ncc3cc(-c4ccccc4Cl)c(=O)n(C[C@H]4CCCO4)c3n2)ccc1N1CCN(C)CC1 Homo sapiens CHEMBL5341436 cell-based format
CHEMBL247667 IC50 = 1.0 nM 504.63 c1ccc(CCNc2ncnc3oc(-c4ccc(OCCN5CCCC5)cc4)c(-c4ccccc4)c23)cc1 Homo sapiens CHEMBL903634 single protein format
CHEMBL5416410 IC50 = 1.0 nM 506.03 Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1.O Homo sapiens CHEMBL5265489 single protein format
CHEMBL5434969 IC50 = 1.1 nM 561.09 COc1cc(Nc2ncc3cc(-c4ccccc4Cl)c(=O)n(C[C@H]4CCCO4)c3n2)ccc1N1CCN(C)CC1 Homo sapiens CHEMBL5341436 cell-based format
CHEMBL5431312 IC50 = 1.3 nM 589.54 Cc1cc(Nc2ncc3cc(-c4ccccc4Br)c(=O)n(C[C@H]4CCCO4)c3n2)ccc1N1CCN(C)CC1 Homo sapiens CHEMBL5341436 cell-based format
CHEMBL5404048 IC50 = 1.9 nM 446.94 Cc1cccc(Nc2ncc3cc(-c4ccccc4Cl)c(=O)n(C[C@H]4CCCO4)c3n2)c1 Homo sapiens CHEMBL5341436 cell-based format
CHEMBL487242 IC50 = 2.0 nM 430.56 COC(C)(C)CCn1nc(Nc2c(C)cccc2C)c2cnc(Nc3ccccc3)nc21 Homo sapiens CHEMBL3429155 single protein format
CHEMBL5404162 IC50 = 2.6 nM 528.63 Cc1cc(Nc2ncc3cc(-c4ccccc4F)c(=O)n(C[C@H]4CCCO4)c3n2)ccc1N1CCN(C)CC1 Homo sapiens CHEMBL5341436 cell-based format
CHEMBL288441 IC50 = 2.7 nM 530.46 COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl Homo sapiens CHEMBL1244331 single protein format
CHEMBL5413451 IC50 = 2.8 nM 555.64 Cc1cc(Nc2ncc3cc(-c4ccccc4[N+](=O)[O-])c(=O)n(C[C@H]4CCCO4)c3n2)ccc1N1CCN(C)CC1 Homo sapiens CHEMBL5341436 cell-based format
CHEMBL4641234 IC50 = 4.0 nM 459.55 COc1cc(Nc2ncc3c(n2)N(C)c2ccccc2C(=O)N3)ccc1N1C[C@@H](C)N[C@@H](C)C1 Homo sapiens CHEMBL4611611 assay format
CHEMBL4640664 IC50 = 4.0 nM 445.53 COc1cc(Nc2ncc3c(n2)N(C)c2ccccc2C(=O)N3)ccc1N1CCN(C)CC1 Homo sapiens CHEMBL4611611 assay format