Q07869 | PPARA_HUMAN | Peroxisome proliferator-activated receptor alpha (PPARA)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00104 | Hormone_recep - Ligand-binding domain of nuclear hormone receptor | 269~448 | |
| PF00105 | zf-C4 - Double treble clef zinc finger, C4 type | 101~167 |
3D structures mapped by conservation among orthologs
[ Domain: "Nuclear receptor ligand-binding domain" // Hormone_recep_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL206202 |  |
IC50 | < | 1.0 | nM | 458.9 | CC[C@@](C)(Cc1ccc(OCCCOc2ccc(CC(F)(F)F)cc2Cl)cc1)C(=O)O | Homo sapiens | CHEMBL867227 | single protein format |
| CHEMBL424685 |  |
IC50 | = | 2.0 | nM | 459.03 | CC[C@@](C)(Cc1ccc(OCCCOc2ccc(C3CCCCC3)cc2Cl)cc1)C(=O)O | Homo sapiens | CHEMBL867227 | single protein format |
| CHEMBL382178 |  |
IC50 | = | 3.0 | nM | 460.88 | CC[C@@](C)(Cc1ccc(OCCCOc2ccc(OC(F)(F)F)cc2Cl)cc1)C(=O)O | Homo sapiens | CHEMBL867227 | single protein format |
| CHEMBL424674 |  |
IC50 | = | 3.0 | nM | 444.88 | CC[C@@](C)(Cc1ccc(OCCCOc2ccc(C(F)(F)F)cc2Cl)cc1)C(=O)O | Homo sapiens | CHEMBL867227 | single protein format |
| CHEMBL234659 |  |
IC50 | = | 4.7 | nM | 492.52 | COc1cc(OCC(=O)O)c(C)cc1SCc1ccc(OCc2ccc(C(F)(F)F)cc2)cc1 | Homo sapiens | CHEMBL896361 | single protein format |
| CHEMBL203621 |  |
IC50 | = | 5.0 | nM | 486.97 | CCC(C)(Cc1ccc(OCCCOc2ccc(Oc3ccc(F)cc3)cc2Cl)cc1)C(=O)O | Homo sapiens | CHEMBL867227 | single protein format |
| CHEMBL203408 |  |
IC50 | = | 6.0 | nM | 486.97 | CC[C@](C)(Cc1ccc(OCCCOc2ccc(Oc3ccc(F)cc3)cc2Cl)cc1)C(=O)O | Homo sapiens | CHEMBL867227 | single protein format |
| CHEMBL3264926 |  |
IC50 | = | 6.6 | nM | 582.77 | CCn1c(CCCc2ccc(OC(C)(C)C(=O)NS(=O)(=O)C3CC3)cc2)nn(Cc2ccc(C(C)(C)C)cc2)c1=O | Homo sapiens | CHEMBL3269597 | cell-based format |
| CHEMBL369725 |  |
IC50 | = | 7.0 | nM | 446.97 | CCC(C)(C)c1ccc(OCCCOc2ccc3c(c2)O[C@@](C)(C(=O)O)CC3)c(Cl)c1 | Homo sapiens | CHEMBL828473 | single protein format |
| CHEMBL205803 |  |
IC50 | = | 10.0 | nM | 474.9 | CC[C@@](C)(Cc1ccc(OCCCOc2ccc(OCC(F)(F)F)cc2Cl)cc1)C(=O)O | Homo sapiens | CHEMBL867227 | single protein format |
| CHEMBL344282 |  |
IC50 | = | 12.0 | nM | 437.54 | Cc1ccc(Cn2nc(CCCc3ccc(OC(C)(C)C(=O)O)cc3)n(C)c2=O)cc1C | Homo sapiens | CHEMBL765406 | single protein format |
| CHEMBL148639 |  |
IC50 | = | 15.0 | nM | 465.59 | Cn1c(CCCc2ccc(OC(C)(C)C(=O)O)cc2)nn(Cc2ccc(C(C)(C)C)cc2)c1=O | Homo sapiens | CHEMBL765406 | single protein format |
| CHEMBL176075 |  |
IC50 | = | 15.0 | nM | 473.01 | CC[C@]1(C(=O)O)CCc2ccc(OCCCOc3ccc(C4CCCCC4)cc3Cl)cc2O1 | Homo sapiens | CHEMBL828473 | single protein format |
| CHEMBL149676 |  |
IC50 | = | 16.0 | nM | 451.57 | CCCn1c(CCCc2ccc(OC(C)(C)C(=O)O)cc2)nn(Cc2ccc(C)cc2)c1=O | Homo sapiens | CHEMBL765406 | single protein format |
| CHEMBL180019 |  |
IC50 | = | 16.0 | nM | 432.94 | CC(C)Cc1ccc(OCCCOc2ccc3c(c2)O[C@@](C)(C(=O)O)CC3)c(Cl)c1 | Homo sapiens | CHEMBL828473 | single protein format |
| CHEMBL207103 |  |
IC50 | = | 16.0 | nM | 436.43 | CCCc1c(OCCCNc2ccc(CC(=O)O)cc2)ccc2c(C(F)(F)F)noc12 | Homo sapiens | CHEMBL870175 | single protein format |
| CHEMBL345721 |  |
IC50 | = | 19.0 | nM | 467.57 | CCCn1c(CCCc2ccc(OC(C)(C)C(=O)O)cc2)nn(Cc2cccc(OC)c2)c1=O | Homo sapiens | CHEMBL765406 | single protein format |
| CHEMBL210973 |  |
IC50 | = | 19.0 | nM | 437.41 | CCCc1c(OCCCOc2ccc(CC(=O)O)cc2)ccc2c(C(F)(F)F)noc12 | Homo sapiens | CHEMBL870175 | single protein format |
| CHEMBL1783064 |  |
IC50 | = | 19.0 | nM | 487.04 | CC(C)C1=CC(C)(C)Oc2cc(OCCCOc3ccc(CC(C)(C)C(=O)O)cc3)c(Cl)cc21 | Homo sapiens | CHEMBL867227 | single protein format |
| CHEMBL2113219 |  |
IC50 | = | 20.0 | nM | 512.95 | CC1(C)C=C(C(F)(F)F)c2cc(Cl)c(OCCCOc3ccc(CC(C)(C)C(=O)O)cc3)cc2O1 | Homo sapiens | CHEMBL867227 | single protein format |