Q07817 | B2CL1_HUMAN | Bcl-2-like protein 1 (BCL2L1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00452 | Bcl-2 - Apoptosis regulator proteins, Bcl-2 family | 90~188 | |
| PF02180 | BH4 - Bcl-2 homology region 4 | 1~26 |
3D structures mapped by conservation among orthologs
[ Domain: "Bcl-2 inhibitors of programmed cell death" // Bcl-2 ]
- 1BXL
- 1G5J
- 1LXL
- 1MAZ
- 1R2D
- 1R2E
- 1R2G
- 1R2H
- 1R2I
- 1YSG
- 1YSI
- 1YSN
- 2B48
- 2LP8
- 2LPC
- 2M03
- 2M04
- 2ME8
- 2ME9
- 2MEJ
- 2O1Y
- 2O2M
- 2O2N
- 2P1L
- 2PON
- 2YJ1
- 2YQ6
- 2YQ7
- 2YXJ
- 3CVA
- 3FDL
- 3FDM
- 3INQ
- 3IO8
- 3PL7
- 3QKD
- 3R85
- 3SP7
- 3SPF
- 3WIZ
- 3ZK6
- 3ZLN
- 3ZLO
- 3ZLR
- 4A1U
- 4A1W
- 4AQ3
- 4BPK
- 4C52
- 4C5D
- 4CIN
- 4EHR
- 4HNJ
- 4PPI
- 4QVE
- 4QVF
- 4QVX
- 4TUH
- 4Z9V
- 5AGX
- 5B1Z
- 5C3G
- 5FMJ
- 5FMK
- 5VAY
- 5VX3
- 6BF2
- 6DCN
- 6DCO
- 6GL8
- 6IJQ
- 6O0K
- 6O0L
- 6O0M
- 6O0P
- 6QGG
- 6QGH
- 6QGK
- 6RNU
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3287301 |  |
IC50 | = | 1.0 | nM | 570.7 | O=C(Nc1nc2ccccc2s1)c1cccc2c1CN(c1nc(C(=O)O)c(CCCOc3ccccc3)s1)CC2 | Homo sapiens | CHEMBL3291801 | single protein format |
| CHEMBL3400497 |  |
IC50 | = | 1.5 | nM | 552.73 | O=C(O)c1nc(-c2ccc3c(c2)/C(=N/Nc2nc4ccccc4s2)CCC3)sc1CCCCc1ccccc1 | Homo sapiens | CHEMBL3406793 | single protein format |
| CHEMBL3342187 |  |
IC50 | = | 3.0 | nM | 583.74 | NCc1ccc(OCCCc2sc(-c3ccc4c(c3)/C(=N/Nc3nc5ccccc5s3)CCC4)nc2C(=O)O)cc1 | Homo sapiens | CHEMBL3406793 | single protein format |
| CHEMBL3287299 |  |
IC50 | = | 4.0 | nM | 546.65 | O=C(Nc1nc2ccccc2s1)c1cccc2c1CN(c1ccc(/C=C/Cc3ccccc3)c(C(=O)O)n1)CC2 | Homo sapiens | CHEMBL3291801 | single protein format |
| CHEMBL2398255 |  |
IC50 | = | 6.0 | nM | 415.48 | O=C(O)c1cccc(-c2ccc3c(c2)/C(=N\Nc2nc4ccccc4s2)CCN3)n1 | Homo sapiens | CHEMBL2399239 | single protein format |
| CHEMBL3287302 |  |
IC50 | = | 7.0 | nM | 584.72 | O=C(Nc1nc2ccccc2s1)c1cccc2c1CN(c1nc(C(=O)O)c(CCCCOc3ccccc3)s1)CC2 | Homo sapiens | CHEMBL3291801 | single protein format |
| CHEMBL2398250 |  |
IC50 | = | 10.0 | nM | 428.52 | O=C(O)c1cccc(-c2ccc3c(c2)/C(=N\Nc2nc4ccccc4s2)CCCC3)n1 | Homo sapiens | CHEMBL2399239 | single protein format |
| CHEMBL3287283 |  |
IC50 | = | 13.0 | nM | 420.52 | O=C(O)c1csc(-c2ccc3c(c2)/C(=N/Nc2nc4ccccc4s2)CCC3)n1 | Homo sapiens | CHEMBL3291801 | single protein format |
| CHEMBL2398254 |  |
IC50 | = | 14.0 | nM | 432.53 | O=C(O)c1cccc(-c2ccc3c(c2)/C(=N\Nc2nc4ccccc4s2)CCS3)n1 | Homo sapiens | CHEMBL2399239 | single protein format |
| CHEMBL3287296 |  |
IC50 | = | 16.0 | nM | 564.67 | O=C(Nc1nc2ccccc2s1)c1cccc2c1CN(c1ccc(CCCOc3ccccc3)c(C(=O)O)n1)CC2 | Homo sapiens | CHEMBL3291801 | single protein format |
| CHEMBL2398252 |  |
IC50 | = | 17.0 | nM | 428.52 | CC1C/C(=N/Nc2nc3ccccc3s2)c2cc(-c3cccc(C(=O)O)n3)ccc2C1 | Homo sapiens | CHEMBL2399239 | single protein format |
| CHEMBL2312470 |  |
IC50 | = | 18.0 | nM | 461.59 | Nc1ccc(Sc2ccc3c4c(cccc24)C2=NC(=O)C(NCCCc4ccccc4)=C23)cc1 | Homo sapiens | CHEMBL2318339 | assay format |
| CHEMBL3287282 |  |
IC50 | = | 20.0 | nM | 414.49 | O=C(O)c1cccc(-c2ccc3c(c2)/C(=N/Nc2nc4ccccc4s2)CCC3)n1 | Homo sapiens | CHEMBL3291801 | single protein format |
| CHEMBL2398173 |  |
IC50 | = | 23.0 | nM | 414.49 | O=C(O)c1cccc(-c2ccc3c(c2)/C(=N\Nc2nc4ccccc4s2)CCC3)n1 | Homo sapiens | CHEMBL2399239 | single protein format |
| CHEMBL2398260 |  |
IC50 | = | 24.0 | nM | 420.52 | O=C(O)c1csc(-c2ccc3c(c2)/C(=N\Nc2nc4ccccc4s2)CCC3)n1 | Homo sapiens | CHEMBL2399239 | single protein format |
| CHEMBL3287295 |  |
IC50 | = | 32.0 | nM | 548.67 | O=C(Nc1nc2ccccc2s1)c1cccc2c1CN(c1ccc(CCCc3ccccc3)c(C(=O)O)n1)CC2 | Homo sapiens | CHEMBL3291801 | single protein format |
| CHEMBL2312476 |  |
IC50 | = | 37.0 | nM | 472.59 | CC(C)c1ccc(Oc2ccc3c4c(cccc24)C2=NC(=O)C(NCCCc4ccccc4)=C23)cc1 | Homo sapiens | CHEMBL2318339 | assay format |
| CHEMBL3287297 |  |
IC50 | = | 43.0 | nM | 578.69 | O=C(Nc1nc2ccccc2s1)c1cccc2c1CN(c1ccc(CCCCOc3ccccc3)c(C(=O)O)n1)CC2 | Homo sapiens | CHEMBL3291801 | single protein format |
| CHEMBL2312483 |  |
IC50 | = | 43.0 | nM | 439.58 | O=C1N=C2C(=C1NCCCc1ccccc1)c1ccc(N3CCSCC3)c3cccc2c13 | Homo sapiens | CHEMBL2318339 | assay format |
| CHEMBL2398257 |  |
IC50 | = | 47.0 | nM | 428.52 | CC1CC/C(=N/Nc2nc3ccccc3s2)c2cc(-c3cccc(C(=O)O)n3)ccc21 | Homo sapiens | CHEMBL2399239 | single protein format |