Q07075 | AMPE_HUMAN | Glutamyl aminopeptidase (ENPEP)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01433 | Peptidase_M1 - Peptidase family M1 domain | 321~538 | |
| PF11838 | ERAP1_C - ERAP1-like C-terminal domain | 616~933 | |
| PF17900 | Peptidase_M1_N - Peptidase M1 N-terminal domain | 99~286 |
3D structures mapped by conservation among orthologs
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // ERAP1_C ]
[ Domain: "Baculovirus p35 protein-related" // Peptidase_M1_2 ]
[ Domain: "ARM repeat" // ERAP1_C_1 ]
[ Domain: "Metalloproteases ("zincins") catalytic domain" // Peptidase_M1_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL146746 |  |
Ki | = | 0.873 | nM | 483.57 | CC[C@@H](C)[C@H](NC(=O)[C@H](S)[C@H](N)CCS(=O)(=O)O)C(=O)N1CCC(C(=O)O)[C@H]1C(=O)O | Homo sapiens | CHEMBL873060 | single protein format |
| CHEMBL358903 |  |
Ki | = | 3.2 | nM | 457.53 | CC[C@@H](C)[C@H](NC(=O)[C@H](S)[C@H](N)CCS(=O)(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)O | Homo sapiens | CHEMBL873060 | single protein format |
| CHEMBL348205 |  |
Ki | = | 3.56 | nM | 421.47 | CC[C@@H](C)[C@H](NC(=O)[C@H](S)[C@H](N)CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)O | Homo sapiens | CHEMBL873060 | single protein format |
| CHEMBL148777 |  |
Ki | = | 3.6 | nM | 493.58 | CC[C@@H](C)[C@H](NC(=O)[C@H](S)[C@H](N)CCS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)O | Homo sapiens | CHEMBL873060 | single protein format |
| CHEMBL151631 |  |
Ki | = | 3.83 | nM | 483.57 | CC[C@@H](C)[C@H](NC(=O)[C@H](S)[C@H](N)CCS(=O)(=O)O)C(=O)N1CCC(C(=O)O)[C@@H]1C(=O)O | Homo sapiens | CHEMBL873060 | single protein format |
| CHEMBL147285 |  |
Ki | = | 4.3 | nM | 507.54 | N[C@H](CCS(=O)(=O)O)[C@@H](S)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)O | Homo sapiens | CHEMBL873060 | single protein format |
| CHEMBL359101 |  |
Ki | = | 5.36 | nM | 457.53 | CC[C@@H](C)[C@H](NC(=O)[C@H](S)[C@H](N)CCS(=O)(=O)O)C(=O)N[C@H](CC(=O)O)C(=O)O | Homo sapiens | CHEMBL873060 | single protein format |
| CHEMBL347763 |  |
Ki | = | 9.3 | nM | 557.63 | N[C@H](CCS(=O)(=O)O)[C@@H](S)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCS(=O)(=O)O)C(=O)O | Homo sapiens | CHEMBL873060 | single protein format |
| CHEMBL356858 |  |
Ki | = | 12.0 | nM | 457.44 | CC[C@@H](C)[C@H](NC(=O)[C@H](S)[C@H](N)CCP(=O)(O)O)C(=O)N[C@@H](CC(=O)O)C(=O)O | Homo sapiens | CHEMBL873060 | single protein format |
| CHEMBL4217064 |  |
Ki | = | 13.0 | nM | 421.47 | CC[C@H](C)[C@H](NC(=O)C(S)C(N)CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)O | Homo sapiens | CHEMBL4194806 | single protein format |
| CHEMBL346397 |  |
Ki | = | 13.0 | nM | 421.47 | CC[C@@H](C)[C@H](NC(=O)[C@H](S)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)O | Homo sapiens | CHEMBL873060 | single protein format |
| CHEMBL433935 |  |
Ki | = | 14.7 | nM | 457.53 | CC[C@H](C)[C@@H](NC(=O)[C@H](S)[C@H](N)CCS(=O)(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)O | Homo sapiens | CHEMBL873060 | single protein format |
| CHEMBL148482 |  |
Ki | = | 15.0 | nM | 456.54 | CC[C@@H](C)[C@H](NC(=O)[C@H](S)[C@H](N)CCS(=O)(=O)O)C(=O)N[C@@H](CC(=O)O)C(N)=O | Homo sapiens | CHEMBL873060 | single protein format |
| CHEMBL146922 |  |
Ki | = | 16.0 | nM | 421.47 | CC[C@@H](C)[C@H](NC(=O)[C@@H](S)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)O | Homo sapiens | CHEMBL873060 | single protein format |
| CHEMBL345941 |  |
Ki | = | 20.0 | nM | 457.53 | CC[C@@H](C)[C@H](NC(=O)[C@H](S)[C@@H](N)CCS(=O)(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)O | Homo sapiens | CHEMBL873060 | single protein format |
| CHEMBL151900 |  |
Ki | = | 27.0 | nM | 507.54 | N[C@H](CCS(=O)(=O)O)[C@H](S)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)O | Homo sapiens | CHEMBL873060 | single protein format |
| CHEMBL149449 |  |
Ki | = | 40.0 | nM | 342.44 | CC[C@@H](C)[C@H](NC(=O)[C@H](S)[C@H](N)CCS(=O)(=O)O)C(=O)O | Homo sapiens | CHEMBL873060 | single protein format |
| CHEMBL148781 |  |
Ki | = | 50.0 | nM | 457.53 | CC[C@@H](C)[C@H](NC(=O)[C@@H](S)[C@@H](N)CCS(=O)(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)O | Homo sapiens | CHEMBL873060 | single protein format |
| CHEMBL1161295 |  |
Ki | = | 51.0 | nM | 442.56 | CC[C@@H](C)[C@H](NCC(S)C(N)CCS(N)(=O)=O)C(=O)N[C@@H](CC(=O)O)C(=O)O | Homo sapiens | CHEMBL873060 | single protein format |
| CHEMBL149436 |  |
Ki | = | 53.0 | nM | 457.53 | CC[C@@H](C)[C@H](NC(=O)[C@@H](S)[C@H](N)CCS(=O)(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)O | Homo sapiens | CHEMBL873060 | single protein format |