Q06495 | NPT2A_HUMAN | Sodium-dependent phosphate transport protein 2A (SLC34A1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF02690 | Na_Pi_cotrans - Na+/Pi-cotransporter | 113~204 | |
| PF02690 | Na_Pi_cotrans - Na+/Pi-cotransporter | 375~487 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4161567 |  |
IC50 | = | 100.0 | nM | 411.82 | Cc1[nH]c2c(N3CCC4(CCNC4=O)CC3)c(C#N)c(C(F)(F)F)nc2c1Cl | Homo sapiens | CHEMBL4149751 | cell-based format |
| CHEMBL4168827 |  |
IC50 | = | 120.0 | nM | 425.84 | Cc1[nH]c2c(N3CCC4(CCN(C)C4=O)CC3)c(C#N)c(C(F)(F)F)nc2c1Cl | Homo sapiens | CHEMBL4149751 | cell-based format |
| CHEMBL4176684 |  |
IC50 | = | 130.0 | nM | 358.75 | Cc1[nH]c2c(N3CCC(O)CC3)c(C#N)c(C(F)(F)F)nc2c1Cl | Homo sapiens | CHEMBL4149751 | cell-based format |
| CHEMBL4168403 |  |
IC50 | = | 290.0 | nM | 400.79 | Cc1[nH]c2c(N3CCC(N)(C(N)=O)CC3)c(C#N)c(C(F)(F)F)nc2c1Cl | Homo sapiens | CHEMBL4149751 | cell-based format |
| CHEMBL4175607 |  |
IC50 | = | 380.0 | nM | 374.75 | Cc1[nH]c2c(N3CCO[C@H](CO)C3)c(C#N)c(C(F)(F)F)nc2c1Cl | Homo sapiens | CHEMBL4149751 | cell-based format |
| CHEMBL4164986 |  |
IC50 | = | 390.0 | nM | 374.75 | Cc1[nH]c2c(N3CCO[C@@H](CO)C3)c(C#N)c(C(F)(F)F)nc2c1Cl | Homo sapiens | CHEMBL4149751 | cell-based format |
| CHEMBL4159390 |  |
IC50 | = | 460.0 | nM | 515.99 | O=C(Nc1ccc(Cl)cc1C(=O)N/N=C/c1cccc(F)c1)c1cccc(CSCC(O)CO)c1 | Homo sapiens | CHEMBL4149751 | cell-based format |
| CHEMBL4161567 | |
Ki | = | 82.0 | nM | 411.82 | Cc1[nH]c2c(N3CCC4(CCNC4=O)CC3)c(C#N)c(C(F)(F)F)nc2c1Cl | Homo sapiens | CHEMBL4149762 | cell-based format |
| CHEMBL4168403 | |
Ki | = | 250.0 | nM | 400.79 | Cc1[nH]c2c(N3CCC(N)(C(N)=O)CC3)c(C#N)c(C(F)(F)F)nc2c1Cl | Homo sapiens | CHEMBL4149762 | cell-based format |
| CHEMBL4176684 | |
Ki | = | 440.0 | nM | 358.75 | Cc1[nH]c2c(N3CCC(O)CC3)c(C#N)c(C(F)(F)F)nc2c1Cl | Homo sapiens | CHEMBL4149762 | cell-based format |
| CHEMBL4168827 | |
Ki | = | 530.0 | nM | 425.84 | Cc1[nH]c2c(N3CCC4(CCN(C)C4=O)CC3)c(C#N)c(C(F)(F)F)nc2c1Cl | Homo sapiens | CHEMBL4149762 | cell-based format |
| CHEMBL4159390 | |
Ki | = | 690.0 | nM | 515.99 | O=C(Nc1ccc(Cl)cc1C(=O)N/N=C/c1cccc(F)c1)c1cccc(CSCC(O)CO)c1 | Homo sapiens | CHEMBL4149762 | cell-based format |
| CHEMBL4175607 | |
Ki | = | 750.0 | nM | 374.75 | Cc1[nH]c2c(N3CCO[C@H](CO)C3)c(C#N)c(C(F)(F)F)nc2c1Cl | Homo sapiens | CHEMBL4149762 | cell-based format |