Q06278 | AOXA_HUMAN | Aldehyde oxidase (AOX1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00111 | Fer2 - 2Fe-2S iron-sulfur cluster binding domain | 10~77 | |
| PF00941 | FAD_binding_5 - FAD binding domain in molybdopterin dehydrogenase | 241~418 | |
| PF01315 | Ald_Xan_dh_C - Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain | 594~700 | |
| PF01799 | Fer2_2 - [2Fe-2S] binding domain | 88~162 | |
| PF02738 | MoCoBD_1 - Molybdopterin cofactor-binding domain | 717~955 | |
| PF03450 | CO_deh_flav_C - CO dehydrogenase flavoprotein C-terminal domain | 427~530 | |
| PF20256 | MoCoBD_2 - Molybdopterin cofactor-binding domain | 980~1245 |
3D structures mapped by conservation among orthologs
[ Domain: "CO dehydrogenase ISP C-domain like" // Fer2_2 ]
[ Domain: "Ubiquitin-like" // Fer2 ]
[ Domain: "Molybdenum cofactor-binding domain" // Ald_Xan_dh_C2 ]
[ Domain: "SufE/NifU" // CO_deh_flav_C ]
[ Domain: "FAD-binding domain" // FAD_binding_5 ]
[ Domain: "CO dehydrogenase molybdoprotein N-domain-like" // Ald_Xan_dh_C ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL44 |  |
IC50 | = | 5.0 | nM | 270.24 | O=c1c(-c2ccc(O)cc2)coc2cc(O)cc(O)c12 | Homo sapiens | CHEMBL5233652 | assay format |
| CHEMBL135 |  |
IC50 | = | 5.0 | nM | 272.39 | C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CC[C@@H]2O | Homo sapiens | CHEMBL5233652 | assay format |
| CHEMBL691 |  |
IC50 | = | 5.0 | nM | 296.41 | C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@@]21C | Homo sapiens | CHEMBL5233652 | assay format |
| CHEMBL81 |  |
IC50 | = | 44.5 | nM | 473.59 | O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12 | Homo sapiens | CHEMBL4420028 | subcellular format |
| CHEMBL71 |  |
IC50 | < | 1000.0 | nM | 318.87 | CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc21 | Homo sapiens | CHEMBL5233652 | assay format |
| CHEMBL567 |  |
IC50 | < | 1000.0 | nM | 403.98 | OCCN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 | Homo sapiens | CHEMBL5233652 | assay format |
| CHEMBL81 | |
Ki | = | 0.87 | nM | 473.59 | O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12 | Homo sapiens | CHEMBL5029650 | single protein format |