ProtHub

Q06278 | AOXA_HUMAN | Aldehyde oxidase (AOX1)

Helixβ‑strandTurn secondary structure

Pfam Domain Table

Accession	Domain	Range	Color
PF00111	Fer2	10–77
PF00941	FAD_binding_5	241–418
PF01315	Ald_Xan_dh_C	594–700
PF01799	Fer2_2	88–162
PF02738	MoCoBD_1	717–955
PF03450	CO_deh_flav_C	427–530
PF20256	MoCoBD_2	980–1245

3D structures mapped by conservation among orthologs

[ Domain: "CO dehydrogenase ISP C-domain like" // Fer2_2 ]

[ Domain: "Ubiquitin-like" // Fer2 ]

[ Domain: "Molybdenum cofactor-binding domain" // Ald_Xan_dh_C2 ]

[ Domain: "SufE/NifU" // CO_deh_flav_C ]

[ Domain: "FAD-binding domain" // FAD_binding_5 ]

[ Domain: "CO dehydrogenase molybdoprotein N-domain-like" // Ald_Xan_dh_C ]

[ Alpha Fold Model ] (go)

Known binders annotated in ChEMBL

IC50 CSV Ki CSV

Only the first 20 rows are shown.

molecule_chembl_id	structure	assay_type	relation	value	unit	mol_wt	smiles	organism	assay_chembl_id	bao_label
CHEMBL44		IC50	=	5.0	nM	270.24	O=c1c(-c2ccc(O)cc2)coc2cc(O)cc(O)c12	Homo sapiens	CHEMBL5233652	assay format
CHEMBL135		IC50	=	5.0	nM	272.39	C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CC[C@@H]2O	Homo sapiens	CHEMBL5233652	assay format
CHEMBL691		IC50	=	5.0	nM	296.41	C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@@]21C	Homo sapiens	CHEMBL5233652	assay format
CHEMBL81		IC50	=	44.5	nM	473.59	O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12	Homo sapiens	CHEMBL4420028	subcellular format
CHEMBL71		IC50	<	1000.0	nM	318.87	CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc21	Homo sapiens	CHEMBL5233652	assay format
CHEMBL567		IC50	<	1000.0	nM	403.98	OCCN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	Homo sapiens	CHEMBL5233652	assay format
CHEMBL81		Ki	=	0.87	nM	473.59	O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12	Homo sapiens	CHEMBL5029650	single protein format