Q05940 | VMAT2_HUMAN | Synaptic vesicular amine transporter (SLC18A2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF07690 | MFS_1 - Major Facilitator Superfamily | 127~423 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4205254 |  |
IC50 | = | 16.0 | nM | 439.49 | CCOC(=O)C1CN(CCn2c(=O)[nH]c3ccccc3c2=O)CCC1c1ccc(F)cc1 | Homo sapiens | CHEMBL4202145 | cell-based format |
| CHEMBL4207658 |  |
IC50 | = | 19.7 | nM | 421.5 | CCOC(=O)[C@@H]1CN(CCn2c(=O)[nH]c3ccccc3c2=O)CC[C@@H]1c1ccccc1 | Homo sapiens | CHEMBL4202145 | cell-based format |
| CHEMBL4206824 |  |
IC50 | = | 28.1 | nM | 319.45 | COc1cc2c(cc1OC)C1CC(O)C(CC(C)C)CN1CC2 | Homo sapiens | CHEMBL4202145 | cell-based format |
| CHEMBL4202787 |  |
IC50 | = | 39.4 | nM | 439.49 | CCOC(=O)[C@@H]1CN(CCn2c(=O)[nH]c3ccccc3c2=O)CC[C@@H]1c1ccc(F)cc1 | Homo sapiens | CHEMBL4202145 | cell-based format |
| CHEMBL4214975 |  |
IC50 | = | 85.5 | nM | 439.49 | CCOC(=O)[C@@H]1CN(CCn2c(=O)[nH]c3ccccc3c2=O)CC[C@H]1c1ccc(F)cc1 | Homo sapiens | CHEMBL4202145 | cell-based format |
| CHEMBL4208250 |  |
IC50 | = | 101.0 | nM | 427.53 | CCOC(=O)[C@@H]1CN(CCn2c(=O)[nH]c3ccccc3c2=O)CC[C@@H]1c1cccs1 | Homo sapiens | CHEMBL4202145 | cell-based format |
| CHEMBL4208779 |  |
IC50 | = | 125.0 | nM | 489.49 | CCOC(=O)[C@@H]1CN(CCn2c(=O)[nH]c3ccccc3c2=O)CC[C@@H]1c1cccc(C(F)(F)F)c1 | Homo sapiens | CHEMBL4202145 | cell-based format |
| CHEMBL4213176 |  |
IC50 | = | 142.0 | nM | 479.53 | CCOC(=O)[C@@H]1CN(CCn2c(=O)[nH]c3ccccc3c2=O)CC[C@@H]1c1cccc2c1OCCO2 | Homo sapiens | CHEMBL4202145 | cell-based format |
| CHEMBL213814 |  |
IC50 | = | 154.0 | nM | 347.5 | CCC1(O)CC2c3cc(OC)c(OC)cc3CCN2CC1CC(C)C | Homo sapiens | CHEMBL4202145 | cell-based format |
| CHEMBL51 |  |
IC50 | = | 180.0 | nM | 395.43 | O=C(c1ccc(F)cc1)C1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1 | Homo sapiens | CHEMBL4202145 | cell-based format |
| CHEMBL1091513 |  |
IC50 | = | 213.0 | nM | 517.93 | O=S(=O)(NC1CCC(c2cc(F)ccc2F)(S(=O)(=O)c2ccc(Cl)cc2)CC1)C(F)(F)F | Homo sapiens | CHEMBL5214012 | single protein format |
| CHEMBL579217 |  |
Ki | = | 0.1 | nM | 365.49 | COc1cc2c(cc1OCCCF)CCN1C[C@@H](CC(C)C)[C@H](O)C[C@H]21 | Homo sapiens | CHEMBL1044344 | single protein format |
| CHEMBL4205254 | |
Ki | = | 62.0 | nM | 439.49 | CCOC(=O)C1CN(CCn2c(=O)[nH]c3ccccc3c2=O)CCC1c1ccc(F)cc1 | Homo sapiens | CHEMBL4202136 | cell-based format |
| CHEMBL4207658 | |
Ki | = | 70.0 | nM | 421.5 | CCOC(=O)[C@@H]1CN(CCn2c(=O)[nH]c3ccccc3c2=O)CC[C@@H]1c1ccccc1 | Homo sapiens | CHEMBL4202136 | cell-based format |
| CHEMBL4202787 | |
Ki | = | 74.0 | nM | 439.49 | CCOC(=O)[C@@H]1CN(CCn2c(=O)[nH]c3ccccc3c2=O)CC[C@@H]1c1ccc(F)cc1 | Homo sapiens | CHEMBL4202136 | cell-based format |
| CHEMBL213814 | |
Ki | = | 83.0 | nM | 347.5 | CCC1(O)CC2c3cc(OC)c(OC)cc3CCN2CC1CC(C)C | Homo sapiens | CHEMBL4202136 | cell-based format |
| CHEMBL4206824 | |
Ki | = | 152.0 | nM | 319.45 | COc1cc2c(cc1OC)C1CC(O)C(CC(C)C)CN1CC2 | Homo sapiens | CHEMBL4202136 | cell-based format |
| CHEMBL4214975 | |
Ki | = | 176.0 | nM | 439.49 | CCOC(=O)[C@@H]1CN(CCn2c(=O)[nH]c3ccccc3c2=O)CC[C@H]1c1ccc(F)cc1 | Homo sapiens | CHEMBL4202136 | cell-based format |
| CHEMBL51 | |
Ki | = | 353.0 | nM | 395.43 | O=C(c1ccc(F)cc1)C1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1 | Homo sapiens | CHEMBL4202136 | cell-based format |
| CHEMBL4208250 | |
Ki | = | 450.0 | nM | 427.53 | CCOC(=O)[C@@H]1CN(CCn2c(=O)[nH]c3ccccc3c2=O)CC[C@@H]1c1cccs1 | Homo sapiens | CHEMBL4202136 | cell-based format |