Q05932 | FOLC_HUMAN | Folylpolyglutamate synthase, mitochondrial (FPGS)
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL38937 |  |
Ki | = | 1.7 | nM | 457.92 | NCCCC(NC(=O)c1ccc(NCc2ccc3nc(N)nc(N)c3c2Cl)cc1)C(=O)O | Homo sapiens | CHEMBL678792 | assay format |
| CHEMBL288142 |  |
Ki | = | 8.3 | nM | 458.91 | NCCCC(NC(=O)c1ccc(NCc2ccc3nc(N)nc(O)c3c2Cl)cc1)C(=O)O | Homo sapiens | CHEMBL679521 | assay format |
| CHEMBL130518 |  |
Ki | = | 8.8 | nM | 492.46 | NCCCC(NC(=O)c1ccc(NCc2ccc3nc(N)nc(O)c3c2C(F)(F)F)cc1)C(=O)O | Homo sapiens | CHEMBL679521 | assay format |
| CHEMBL133637 |  |
Ki | = | 11.0 | nM | 492.46 | NCCCC(NC(=O)c1ccc(CNc2ccc3nc(N)nc(O)c3c2C(F)(F)F)cc1)C(=O)O | Homo sapiens | CHEMBL679521 | assay format |
| CHEMBL289923 |  |
Ki | = | 64.0 | nM | 429.48 | NCCCC(NC(=O)c1ccc(NCC2CNc3nc(N)nc(O)c3C2)cc1)C(=O)O | Homo sapiens | CHEMBL682447 | single protein format |
| CHEMBL339240 |  |
Ki | = | 150.0 | nM | 441.46 | Cc1nc(O)c2c(F)c(NCc3ccc(C(=O)NC(CCCN)C(=O)O)cc3)ccc2n1 | Homo sapiens | CHEMBL679521 | assay format |
| CHEMBL83868 |  |
Ki | = | 200.0 | nM | 430.47 | NCCCC(NC(=O)c1ccc(NCC2CNc3nc(N)nc(O)c3N2)cc1)C(=O)O | Homo sapiens | CHEMBL676945 | single protein format |
| CHEMBL331279 |  |
Ki | = | 200.0 | nM | 441.49 | NCCC[C@@H](C(=O)O)N1Cc2cc(NCC3CNc4nc(N)nc(O)c4C3)ccc2C1=O | Homo sapiens | CHEMBL676944 | single protein format |
| CHEMBL281656 |  |
Ki | = | 300.0 | nM | 425.45 | NCCC[C@H](NC(=O)c1ccc(NCc2cnc3nc(N)nc(N)c3n2)cc1)C(=O)O | Homo sapiens | CHEMBL676946 | single protein format |
| CHEMBL43288 |  |
Ki | = | 420.0 | nM | 426.5 | NCCCC(NC(=O)c1ccc(SCc2ccc3ncnc(O)c3c2)cc1)C(=O)O | Homo sapiens | CHEMBL678792 | assay format |
| CHEMBL335629 |  |
Ki | = | 500.0 | nM | 458.91 | NCCCC(NC(=O)c1ccc(CNc2ccc3nc(N)nc(O)c3c2Cl)cc1)C(=O)O | Homo sapiens | CHEMBL679521 | assay format |
| CHEMBL340993 |  |
Ki | = | 900.0 | nM | 442.45 | NCCCC(NC(=O)c1ccc(CNc2ccc3nc(N)nc(O)c3c2F)cc1)C(=O)O | Homo sapiens | CHEMBL679521 | assay format |