Q05655 | KPCD_HUMAN | Protein kinase C delta type (PRKCD)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 352~603 | |
| PF00130 | C1_1 - Phorbol esters/diacylglycerol binding domain (C1 domain) | 159~209 | |
| PF00130 | C1_1 - Phorbol esters/diacylglycerol binding domain (C1 domain) | 231~282 | |
| PF00433 | Pkinase_C - Protein kinase C terminal domain | 624~665 | |
| PF21494 | PKC_C2 - Protein kinase C delta/epsilon/eta/theta, C2 domain | 4~112 |
3D structures mapped by conservation among orthologs
[ Domain: "C2 domain" // KOG0694 ]
[ Domain: "Cysteine-rich domain" // C1_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2151411 |  |
IC50 | = | 0.1 | nM | 452.52 | Cc1cccc2c(C3=C(c4nc(N5CCN(C)CC5)nc5ccccc45)C(=O)NC3=O)c[nH]c12 | Homo sapiens | CHEMBL2156013 | single protein format |
| CHEMBL1996510 |  |
IC50 | = | 0.4 | nM | 424.46 | O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1c1nc(N2CCNCC2)nc2ccccc12 | Homo sapiens | CHEMBL2156013 | single protein format |
| CHEMBL2153750 |  |
IC50 | = | 0.6 | nM | 456.48 | CN1CCN(c2nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3cc(F)ccc3n2)CC1 | Homo sapiens | CHEMBL2156013 | single protein format |
| CHEMBL52529 |  |
IC50 | = | 0.9 | nM | 521.48 | O=C(N[C@@H]1CCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 | Homo sapiens | CHEMBL856212 | single protein format |
| CHEMBL427118 |  |
IC50 | = | 0.9 | nM | 521.48 | O=C(N[C@@H]1CCCC1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 | Homo sapiens | CHEMBL759477 | single protein format |
| CHEMBL48636 |  |
IC50 | = | 0.9 | nM | 521.48 | O=C(NC1CCCC1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 | Homo sapiens | CHEMBL768251 | single protein format |
| CHEMBL71331 |  |
IC50 | = | 1.0 | nM | 521.48 | O=C(NC1CCC[C@@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 | Homo sapiens | CHEMBL766310 | single protein format |
| CHEMBL2151415 |  |
IC50 | = | 1.0 | nM | 438.49 | Cn1cc(C2=C(c3nc(N4CCNCC4)nc4ccccc34)C(=O)NC2=O)c2ccccc21 | Homo sapiens | CHEMBL2156013 | single protein format |
| CHEMBL2153751 |  |
IC50 | = | 1.2 | nM | 472.94 | CN1CCN(c2nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3cc(Cl)ccc3n2)CC1 | Homo sapiens | CHEMBL2156013 | single protein format |
| CHEMBL565612 |  |
IC50 | = | 1.3 | nM | 438.49 | CN1CCN(c2nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3ccccc3n2)CC1 | Homo sapiens | CHEMBL1040088 | single protein format |
| CHEMBL2153748 |  |
IC50 | = | 1.8 | nM | 437.5 | CN1CCN(c2cc3ccccc3c(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)n2)CC1 | Homo sapiens | CHEMBL2156013 | single protein format |
| CHEMBL595521 |  |
IC50 | = | 2.5 | nM | 400.53 | Cc1c(Nc2c(C#N)cncc2/C=C/CCN2CCN(C)CC2)ccc2[nH]ccc12 | Homo sapiens | CHEMBL1070541 | single protein format |
| CHEMBL2151408 |  |
IC50 | = | 2.5 | nM | 472.94 | CN1CCN(c2nc(C3=C(c4c[nH]c5ccc(Cl)cc45)C(=O)NC3=O)c3ccccc3n2)CC1 | Homo sapiens | CHEMBL2156013 | single protein format |
| CHEMBL2151413 |  |
IC50 | = | 2.7 | nM | 480.57 | CC(C)n1cc(C2=C(c3nc(N4CCN(C)CC4)nc4ccccc34)C(=O)NC2=O)c2ccccc21 | Homo sapiens | CHEMBL2156013 | single protein format |
| CHEMBL2153749 |  |
IC50 | = | 3.2 | nM | 452.52 | Cc1cccc2nc(N3CCN(C)CC3)nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c12 | Homo sapiens | CHEMBL2156013 | single protein format |
| CHEMBL605112 |  |
IC50 | = | 3.4 | nM | 462.6 | Cc1c(Nc2c(C#N)cncc2/C=C/CCN2CCN(c3ccccc3)CC2)ccc2[nH]ccc12 | Homo sapiens | CHEMBL1070541 | single protein format |
| CHEMBL75661 |  |
IC50 | = | 4.0 | nM | 551.5 | O=C(N[C@@H]1C[C@H](CO)C[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 | Homo sapiens | CHEMBL766309 | single protein format |
| CHEMBL306427 |  |
IC50 | = | 4.0 | nM | 551.5 | O=C(N[C@H]1C[C@H](CO)C[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 | Homo sapiens | CHEMBL766312 | single protein format |
| CHEMBL2153752 |  |
IC50 | = | 4.1 | nM | 452.52 | Cc1ccc2nc(N3CCN(C)CC3)nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c2c1 | Homo sapiens | CHEMBL2156013 | single protein format |
| CHEMBL583906 |  |
IC50 | = | 4.3 | nM | 462.56 | Cc1c(Nc2c(C#N)cncc2-c2cc3cc(CN4CCNCC4)ccc3o2)ccc2[nH]ccc12 | Homo sapiens | CHEMBL1047184 | single protein format |