Q05586 | NMDZ1_HUMAN | Glutamate receptor ionotropic, NMDA 1 (GRIN1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00060 | Lig_chan - Ligand-gated ion channel | 560~824 | |
| PF01094 | ANF_receptor - Receptor family ligand binding region | 42~357 | |
| PF10613 | Lig_chan-Glu_bd - Ligated ion channel L-glutamate- and glycine-binding site | 454~545 |
3D structures mapped by conservation among orthologs
[ Domain: "Voltage-gated ion channels" // Lig_chan ]
[ Domain: "Periplasmic binding protein-like I" // ANF_receptor_3rd ]
[ Domain: "Periplasmic binding protein-like I" // ANF_receptor_2nd ]
[ Domain: "Periplasmic binding protein-like II" // SBP_bac_3_1st ]
[ Domain: "Periplasmic binding protein-like II" // Lig_chan_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL86313 |  |
IC50 | = | 5.0 | nM | 378.12 | C[C@@H](NCc1cc(Br)cc2nc(O)c(O)nc12)P(=O)(O)O | Homo sapiens | CHEMBL880848 | single protein format |
| CHEMBL117260 |  |
IC50 | = | 5.3 | nM | 345.45 | Oc1nc2cc(C#CCN3CCC(Cc4ccccc4)CC3)ccc2[nH]1 | Homo sapiens | CHEMBL747072 | cell-based format |
| CHEMBL167952 |  |
IC50 | = | 6.0 | nM | 333.67 | C[C@@H](NCc1cc(Cl)cc2nc(O)c(O)nc12)P(=O)(O)O | Homo sapiens | CHEMBL880848 | single protein format |
| CHEMBL19636 |  |
IC50 | = | 6.1 | nM | 363.44 | Oc1nc2cc(C#CCN3CCC(Cc4cccc(F)c4)CC3)ccc2[nH]1 | Homo sapiens | CHEMBL747072 | cell-based format |
| CHEMBL82963 |  |
IC50 | = | 8.0 | nM | 367.22 | C[C@@H](NCc1cc(C(F)(F)F)cc2nc(O)c(O)nc12)P(=O)(O)O | Homo sapiens | CHEMBL880848 | single protein format |
| CHEMBL354295 |  |
IC50 | = | 8.0 | nM | 425.12 | C[C@@H](NCc1cc(I)cc2nc(O)c(O)nc12)P(=O)(O)O | Homo sapiens | CHEMBL880848 | single protein format |
| CHEMBL19506 |  |
IC50 | = | 8.2 | nM | 363.44 | Oc1nc2cc(C#CCN3CCC(Cc4ccc(F)cc4)CC3)ccc2[nH]1 | Homo sapiens | CHEMBL747072 | cell-based format |
| CHEMBL162675 |  |
IC50 | = | 9.0 | nM | 317.21 | C[C@@H](NCc1cc(F)cc2nc(O)c(O)nc12)P(=O)(O)O | Homo sapiens | CHEMBL880848 | single protein format |
| CHEMBL116223 |  |
IC50 | = | 16.0 | nM | 361.51 | Sc1nc2cc(C#CCN3CCC(Cc4ccccc4)CC3)ccc2[nH]1 | Homo sapiens | CHEMBL747072 | cell-based format |
| CHEMBL419399 |  |
IC50 | = | 17.0 | nM | 359.47 | Cc1ccc(CC2CCN(CC#Cc3ccc4[nH]c(O)nc4c3)CC2)cc1 | Homo sapiens | CHEMBL747072 | cell-based format |
| CHEMBL325825 |  |
IC50 | = | 19.0 | nM | 379.89 | Oc1nc2cc(C#CCN3CCC(Cc4ccc(Cl)cc4)CC3)ccc2[nH]1 | Homo sapiens | CHEMBL747072 | cell-based format |
| CHEMBL326742 |  |
IC50 | = | 19.0 | nM | 361.44 | Oc1nc2cc(C#CCN3CCC(O)(Cc4ccccc4)CC3)ccc2[nH]1 | Homo sapiens | CHEMBL747072 | cell-based format |
| CHEMBL326568 |  |
IC50 | = | 26.0 | nM | 375.47 | COc1ccc(CC2CCN(CC#Cc3ccc4[nH]c(O)nc4c3)CC2)cc1 | Homo sapiens | CHEMBL747072 | cell-based format |
| CHEMBL82626 |  |
IC50 | = | 32.0 | nM | 344.22 | C[C@@H](NCc1cc([N+](=O)[O-])cc2nc(O)c(O)nc12)P(=O)(O)O | Homo sapiens | CHEMBL880848 | single protein format |
| CHEMBL325890 |  |
IC50 | = | 49.0 | nM | 346.43 | Oc1nc2ccc(C#CCN3CCC(Cc4ccccc4)CC3)cc2o1 | Homo sapiens | CHEMBL747072 | cell-based format |
| CHEMBL164231 |  |
IC50 | = | 76.0 | nM | 324.23 | C[C@@H](NCc1cc(C#N)cc2nc(O)c(O)nc12)P(=O)(O)O | Homo sapiens | CHEMBL880848 | single protein format |
| CHEMBL117940 |  |
IC50 | = | 89.0 | nM | 359.47 | Oc1nc2cc(C#CCCN3CCC(Cc4ccccc4)CC3)ccc2[nH]1 | Homo sapiens | CHEMBL747072 | cell-based format |
| CHEMBL116224 |  |
IC50 | = | 110.0 | nM | 344.46 | O=C1Cc2cc(C#CCN3CCC(Cc4ccccc4)CC3)ccc2N1 | Homo sapiens | CHEMBL747072 | cell-based format |
| CHEMBL113697 |  |
IC50 | = | 120.0 | nM | 360.46 | Oc1nc2ccc(C#CCCN3CCC(Cc4ccccc4)CC3)cc2o1 | Homo sapiens | CHEMBL747072 | cell-based format |
| CHEMBL115883 |  |
IC50 | = | 180.0 | nM | 375.54 | Sc1nc2cc(C#CCCN3CCC(Cc4ccccc4)CC3)ccc2[nH]1 | Homo sapiens | CHEMBL747072 | cell-based format |