Q05513 | KPCZ_HUMAN | Protein kinase C zeta type (PRKCZ)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 254~516 | |
| PF00130 | C1_1 - Phorbol esters/diacylglycerol binding domain (C1 domain) | 131~182 | |
| PF00433 | Pkinase_C - Protein kinase C terminal domain | 540~580 | |
| PF00564 | PB1 - PB1 domain | 16~97 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4635482 |  |
IC50 | = | 0.1 | nM | 350.44 | Nc1ccc(-c2cc(N[C@H]3CCCCNC3)c3ccncc3c2)c(F)c1 | Homo sapiens | CHEMBL4619369 | single protein format |
| CHEMBL4636488 |  |
IC50 | = | 0.2 | nM | 303.41 | c1ccc(-c2cc(N[C@H]3CCCNC3)c3ccncc3c2)cc1 | Homo sapiens | CHEMBL4619369 | single protein format |
| CHEMBL4646995 |  |
IC50 | = | 0.5 | nM | 318.42 | Nc1ccc(-c2cc(NC3CCCNC3)c3ccncc3c2)cc1 | Homo sapiens | CHEMBL4619369 | single protein format |
| CHEMBL4644939 |  |
IC50 | = | 0.6 | nM | 319.41 | Oc1ccc(-c2cc(NC3CCCNC3)c3ccncc3c2)cc1 | Homo sapiens | CHEMBL4619369 | single protein format |
| CHEMBL4636337 |  |
IC50 | = | 0.8 | nM | 368.43 | Nc1ccc(-c2cc(N[C@H]3CCCCNC3)c3ccncc3c2)c(F)c1F | Homo sapiens | CHEMBL4619369 | single protein format |
| CHEMBL4632523 |  |
IC50 | = | 0.9 | nM | 333.44 | Nc1ccc(-c2cc(N[C@H]3CCCCNC3)c3ccncc3c2)cn1 | Homo sapiens | CHEMBL4619369 | single protein format |
| CHEMBL4643553 |  |
IC50 | = | 1.1 | nM | 351.43 | Nc1ccc(-c2cc(N[C@H]3CCCCNC3)c3ccncc3c2)c(F)n1 | Homo sapiens | CHEMBL4619369 | single protein format |
| CHEMBL4637452 |  |
IC50 | = | 1.4 | nM | 368.43 | Nc1cc(F)c(-c2cc(N[C@H]3CCCCNC3)c3ccncc3c2)cc1F | Homo sapiens | CHEMBL4619369 | single protein format |
| CHEMBL4642166 |  |
IC50 | = | 1.4 | nM | 332.45 | Nc1ccc(-c2cc(N[C@H]3CCCCNC3)c3ccncc3c2)cc1 | Homo sapiens | CHEMBL4619369 | single protein format |
| CHEMBL514197 |  |
IC50 | = | 2.26 | nM | 454.53 | COc1cc(-c2ccc3c(-c4nc5c(N6CCN(C)CC6)cccc5[nH]4)n[nH]c3c2)ccc1O | Homo sapiens | CHEMBL942589 | single protein format |
| CHEMBL4647780 |  |
IC50 | = | 3.4 | nM | 351.43 | Nc1cc(F)c(-c2cc(N[C@H]3CCCCNC3)c3ccncc3c2)cn1 | Homo sapiens | CHEMBL4619369 | single protein format |
| CHEMBL4643470 |  |
IC50 | = | 4.1 | nM | 263.34 | NCCNc1cc(-c2ccccc2)cc2cnccc12 | Homo sapiens | CHEMBL4619369 | single protein format |
| CHEMBL480391 |  |
IC50 | = | 5.18 | nM | 423.52 | CN1CCN(c2cccc3nc(-c4n[nH]c5cc(-c6ccc(N)cc6)ccc45)[nH]c23)CC1 | Homo sapiens | CHEMBL942589 | single protein format |
| CHEMBL473631 |  |
IC50 | = | 5.6 | nM | 424.51 | CN1CCN(c2cccc3[nH]c(-c4n[nH]c5cc(-c6ccc(O)cc6)ccc45)nc23)CC1 | Homo sapiens | CHEMBL942589 | single protein format |
| CHEMBL4641918 |  |
IC50 | = | 6.4 | nM | 303.41 | c1ccc(-c2cc(NC3CCCNC3)c3ccncc3c2)cc1 | Homo sapiens | CHEMBL4619369 | single protein format |
| CHEMBL4632384 |  |
IC50 | = | 9.7 | nM | 317.44 | c1ccc(-c2cc(N[C@H]3CCCCNC3)c3ccncc3c2)cc1 | Homo sapiens | CHEMBL4619369 | single protein format |
| CHEMBL4213984 |  |
IC50 | = | 10.0 | nM | 381.44 | COc1cc2c(cc1-n1cnc3ccc(-c4ccnc5[nH]ccc45)cc31)CNC2 | Homo sapiens | CHEMBL4189554 | assay format |
| CHEMBL3732444 |  |
IC50 | = | 12.0 | nM | 351.48 | c1cc(-c2nc(N3CCNCC3)c3c4c(sc3n2)CCCC4)ccn1 | Homo sapiens | CHEMBL4623319 | cell-based format |
| CHEMBL4642061 |  |
IC50 | = | 13.0 | nM | 360.46 | CC(=O)Nc1ccc(-c2cc(NC3CCCNC3)c3ccncc3c2)cc1 | Homo sapiens | CHEMBL4619369 | single protein format |
| CHEMBL4644763 |  |
IC50 | = | 13.0 | nM | 330.39 | c1cc2cc(-c3cncc4ccc(O[C@H]5CCNC5)cc34)cnc2[nH]1 | Homo sapiens | CHEMBL4619369 | single protein format |