Q05469 | LIPS_HUMAN | Hormone-sensitive lipase (LIPE)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF06350 | HSL_N - Hormone-sensitive lipase (HSL) N-terminus | 308~615 | |
| PF07859 | Abhydrolase_3 - alpha/beta hydrolase fold | 647~795 | |
| PF07859 | Abhydrolase_3 - alpha/beta hydrolase fold | 962~1027 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL419197 |  |
IC50 | = | 1.0 | nM | 359.43 | COc1cccc(N2CCN(C(=O)n3oc(=O)c(C(C)C)c3C)CC2)c1 | Homo sapiens | CHEMBL695907 | single protein format |
| CHEMBL322794 |  |
IC50 | = | 1.0 | nM | 280.37 | CCCCc1c(C)n(C(=O)N2CCC(C)CC2)oc1=O | Homo sapiens | CHEMBL695907 | single protein format |
| CHEMBL49895 |  |
IC50 | = | 1.0 | nM | 403.52 | CC(C)(C)C1CCC(C(=O)Nc2ccc(OC(=O)NN3CCOCC3)cc2)CC1 | Homo sapiens | CHEMBL695909 | single protein format |
| CHEMBL4063082 |  |
IC50 | = | 2.0 | nM | 436.58 | O=C(Nc1ccc(Cl)cc1B(O)O)c1ccc(Oc2ccc(C(F)(F)F)cc2)nc1 | Homo sapiens | CHEMBL3999937 | cell-based format |
| CHEMBL107197 |  |
IC50 | = | 2.0 | nM | 294.38 | Cc1c(C(C)C)c(=O)on1C(=O)N(C)Cc1cccs1 | Homo sapiens | CHEMBL695907 | single protein format |
| CHEMBL109116 |  |
IC50 | = | 2.0 | nM | 252.31 | Cc1c(C(C)C)c(=O)on1C(=O)N1CCCCC1 | Homo sapiens | CHEMBL695907 | single protein format |
| CHEMBL3643710 |  |
IC50 | = | 2.4 | nM | 385.43 | CC(C)[C@@H]1C[C@@]2(CC[C@H]1O)CCN(c1ccc(OCC(F)(F)F)cc1)C2=O | Homo sapiens | CHEMBL3705423 | single protein format |
| CHEMBL295166 |  |
IC50 | = | 3.0 | nM | 383.45 | CC(C)(C)OC(=O)Nc1ccc(OC(=O)NN2CCc3ccccc3C2)cc1 | Homo sapiens | CHEMBL695909 | single protein format |
| CHEMBL320813 |  |
IC50 | = | 3.0 | nM | 296.37 | CCOCCc1c(C)n(C(=O)N2CCC(C)CC2)oc1=O | Homo sapiens | CHEMBL695907 | single protein format |
| CHEMBL106581 |  |
IC50 | = | 3.0 | nM | 280.37 | Cc1c(CC(C)C)c(=O)on1C(=O)N1CCC(C)CC1 | Homo sapiens | CHEMBL695907 | single protein format |
| CHEMBL3643709 |  |
IC50 | = | 3.7 | nM | 385.43 | CCC[C@@H]1C[C@@]2(CC[C@H]1O)CCN(c1ccc(OCC(F)(F)F)cc1)C2=O | Homo sapiens | CHEMBL3705423 | single protein format |
| CHEMBL105834 |  |
IC50 | = | 4.0 | nM | 306.34 | Cc1c(C(C)C)c(=O)on1C(=O)N(C)Cc1ccccc1F | Homo sapiens | CHEMBL695907 | single protein format |
| CHEMBL110763 |  |
IC50 | = | 4.0 | nM | 306.41 | Cc1c(C2CCCCC2)c(=O)on1C(=O)N1CCC(C)CC1 | Homo sapiens | CHEMBL695907 | single protein format |
| CHEMBL106756 |  |
IC50 | = | 4.0 | nM | 278.31 | Cc1c(C(C)C)c(=O)on1C(=O)N(C)Cc1ccco1 | Homo sapiens | CHEMBL695907 | single protein format |
| CHEMBL110343 |  |
IC50 | = | 4.0 | nM | 330.38 | Cc1c(CCOc2ccccc2)c(=O)on1C(=O)N1CCCCC1 | Homo sapiens | CHEMBL695907 | single protein format |
| CHEMBL110653 |  |
IC50 | = | 5.0 | nM | 266.34 | Cc1c(CC(C)C)c(=O)on1C(=O)N1CCCCC1 | Homo sapiens | CHEMBL695907 | single protein format |
| CHEMBL107365 |  |
IC50 | = | 5.0 | nM | 306.34 | Cc1c(C(C)C)c(=O)on1C(=O)N(C)Cc1cccc(F)c1 | Homo sapiens | CHEMBL695907 | single protein format |
| CHEMBL106314 |  |
IC50 | = | 5.0 | nM | 288.35 | Cc1c(C(C)C)c(=O)on1C(=O)N(C)Cc1ccccc1 | Homo sapiens | CHEMBL695907 | single protein format |
| CHEMBL49417 |  |
IC50 | = | 5.0 | nM | 370.41 | O=C(Cc1ccc(OC(=O)NN2CCOCC2)cc1)OCc1ccccc1 | Homo sapiens | CHEMBL695909 | single protein format |
| CHEMBL106045 |  |
IC50 | = | 5.0 | nM | 300.36 | Cc1c(Cc2ccccc2)c(=O)on1C(=O)N1CCCCC1 | Homo sapiens | CHEMBL695907 | single protein format |