ProtHub

Q05397 | FAK1_HUMAN | Focal adhesion kinase 1 (PTK2)

Pfam Domain Table

Accession	Domain	Range
PF00373	FERM_M - FERM central domain	136~249
PF03623	Focal_AT - Focal adhesion targeting region	914~1045
PF07714	PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase	422~676
PF18038	FERM_N_2 - FERM N-terminal domain	35~130
PF21477	FERM_C_FAK1 - FAK1/PYK2, FERM domain C-lobe	260~357

3D structures mapped by conservation among orthologs

[ Alpha Fold Model ] (go)

Known binders annotated in ChEMBL

IC50 CSV Ki CSV

Only the first 20 rows are shown.

molecule_chembl_id	assay_type	relation	value	unit	mol_wt	smiles	organism	assay_chembl_id	bao_label
CHEMBL5170906	IC50	=	0.1	nM	518.11	CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(CN3CCSCC3)cc2)ncc1Cl	Homo sapiens	CHEMBL5109392	single protein format
CHEMBL5196177	IC50	=	0.1165	nM	596.05	CCOP(=O)(CC(=O)Nc1ccc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)cc1)OCC	Homo sapiens	CHEMBL5109392	single protein format
CHEMBL5187385	IC50	=	0.161	nM	587.1	CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(NC(=O)CN3CCC(C(=O)O)CC3)cc2)ncc1Cl	Homo sapiens	CHEMBL5109392	single protein format
CHEMBL5190968	IC50	=	0.1924	nM	587.15	CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(CN3CCC(C(=O)NCCO)CC3)cc2)ncc1Cl	Homo sapiens	CHEMBL5109392	single protein format
CHEMBL5176990	IC50	=	0.2131	nM	530.09	CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(CN3CCC(CO)CC3)cc2)ncc1Cl	Homo sapiens	CHEMBL5109392	single protein format
CHEMBL5204729	IC50	=	0.275	nM	546.05	CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(OCC(=O)N3CCOCC3)cc2)ncc1Cl	Homo sapiens	CHEMBL5109392	single protein format
CHEMBL5186801	IC50	=	0.2963	nM	544.08	CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(CN3CCC(C(=O)O)CC3)cc2)ncc1Cl	Homo sapiens	CHEMBL5109392	single protein format
CHEMBL3692193	IC50	=	0.3	nM	469.51	CN1CCc2cc(Nc3ncc(C(F)(F)F)c(CCc4ccccc4CC(N)=O)n3)ccc2C1	Homo sapiens	CHEMBL3705701	cell-based format
CHEMBL5178369	IC50	=	0.3146	nM	553.02	CCOP(=O)(Cc1ccc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)cc1)OCC	Homo sapiens	CHEMBL5109392	single protein format
CHEMBL3692188	IC50	=	0.39	nM	525.58	CC(=O)N1CCC(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4ccccc4CC(N)=O)n3)cc2)CC1	Homo sapiens	CHEMBL3705701	cell-based format
CHEMBL487229	IC50	=	0.5	nM	506.51	CN(c1ccccc1CNc1nc(Nc2ccc3c(c2)CNC3=O)ncc1C(F)(F)F)S(C)(=O)=O	Homo sapiens	CHEMBL962347	single protein format
CHEMBL3892377	IC50	=	0.51	nM	557.4	C=CCN(c1ncccc1CNc1nc(Nc2cccc(Br)c2)ncc1C(F)(F)F)S(C)(=O)=O	Homo sapiens	CHEMBL3873677	cell-based format
CHEMBL5192604	IC50	=	0.5794	nM	572.13	CCOC(=O)C1CCN(Cc2ccc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C(C)C)n3)cc2)CC1	Homo sapiens	CHEMBL5109392	single protein format
CHEMBL4862042	IC50	=	0.6	nM	509.51	CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NCc3cccnc3N(C)S(C)(=O)=O)n2)cc1	Homo sapiens	CHEMBL4814464	single protein format
CHEMBL4752642	IC50	=	0.6	nM	575.03	C=CC(=O)NCCNc1c(NCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NC)n3)cc2)c(=O)c1=O	Homo sapiens	CHEMBL4704547	cell-based format
CHEMBL3639910	IC50	=	0.6	nM	526.56	CC(=O)N1CCN(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4ccccc4CC(N)=O)n3)cc2)CC1	Homo sapiens	CHEMBL3705701	cell-based format
CHEMBL3137331	IC50	=	0.6	nM	510.5	CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NCc3nccnc3N(C)S(C)(=O)=O)n2)cc1	Homo sapiens	CHEMBL4353544	single protein format
CHEMBL3692189	IC50	=	0.77	nM	525.58	CC(=O)C1CCN(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4ccccc4CC(N)=O)n3)cc2)CC1	Homo sapiens	CHEMBL3705701	cell-based format
CHEMBL3692185	IC50	=	0.81	nM	498.55	NC(=O)Cc1ccccc1CCc1nc(Nc2ccc(N3CCC(N)CC3)cc2)ncc1C(F)(F)F	Homo sapiens	CHEMBL3705701	cell-based format
CHEMBL488247	IC50	=	0.94	nM	529.57	CN(c1ccccc1CNc1nc(Nc2ccc(S(C)(=O)=O)cc2)ncc1C(F)(F)F)S(C)(=O)=O	Homo sapiens	CHEMBL962347	single protein format

Pfam Domain Table

[ Domain: "PH domain-like" // FERM_C_FAK1 ]

[ Domain: "Acyl-CoA binding protein-like" // FERM_M ]

[ Domain: "FAT domain of focal adhesion kinase" // Focal_AT ]

[ Domain: "Ubiquitin-like" // KOG4257 ]

[ Domain: "Protein kinase" // Pkinase_Tyr ]

[ Domain: "Periplasmic binding protein-like II" // SBP_bac_1_N_1 ]