Q04844 | ACHE_HUMAN | Acetylcholine receptor subunit epsilon (CHRNE)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF02931 | Neur_chan_LBD - Neurotransmitter-gated ion-channel ligand binding domain | 26~240 | |
| PF02932 | Neur_chan_memb - Neurotransmitter-gated ion-channel transmembrane region | 247~474 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4435544 |  |
IC50 | = | 6.0 | nM | 537.66 | O=c1ccc2ccc(OCCCCCCCn3cc(CNc4c5c(nc6ccccc46)CCCC5)nn3)cc2o1 | Homo sapiens | CHEMBL4368193 | single protein format |
| CHEMBL4471876 |  |
IC50 | = | 27.0 | nM | 558.08 | Cc1cc(=O)oc2cc(OCCCCCn3cc(CNc4c5c(nc6cc(Cl)ccc46)CCCC5)nn3)ccc12 | Homo sapiens | CHEMBL4368193 | single protein format |
| CHEMBL95 |  |
IC50 | = | 44.0 | nM | 198.27 | Nc1c2c(nc3ccccc13)CCCC2 | Homo sapiens | CHEMBL917782 | single protein format |
| CHEMBL4518438 |  |
IC50 | = | 46.5 | nM | 481.52 | Cc1nn(CC(=O)N/N=C/c2ccccc2)c(=O)n1-c1ccc(C(=O)N/N=C/c2ccccc2)cc1 | Homo sapiens | CHEMBL4368212 | single protein format |
| CHEMBL4516351 |  |
IC50 | = | 57.4 | nM | 550.41 | Cc1nn(CC(=O)N/N=C/c2ccc(Cl)cc2)c(=O)n1-c1ccc(C(=O)N/N=C/c2ccc(Cl)cc2)cc1 | Homo sapiens | CHEMBL4368212 | single protein format |
| CHEMBL4514263 |  |
IC50 | = | 62.3 | nM | 541.57 | COc1ccc(/C=N/NC(=O)Cn2nc(C)n(-c3ccc(C(=O)N/N=C/c4ccc(OC)cc4)cc3)c2=O)cc1 | Homo sapiens | CHEMBL4368212 | single protein format |
| CHEMBL2376519 |  |
IC50 | = | 81.82 | nM | 259.36 | S=c1[nH]nc(-c2cccs2)n1-c1ccccc1 | Homo sapiens | CHEMBL4368200 | single protein format |
| CHEMBL224906 |  |
IC50 | = | 125.0 | nM | 228.29 | Nc1c2c(nc3c(CO)cccc13)CCCC2 | Homo sapiens | CHEMBL917782 | single protein format |
| CHEMBL4473371 |  |
Ki | = | 3.07 | nM | 489.59 | COc1cccc(-n2c(S)nnc2-c2ccc(-c3nnc(S)n3-c3cccc(OC)c3)nc2)c1 | Homo sapiens | CHEMBL4368211 | single protein format |
| CHEMBL5176418 |  |
Ki | = | 120.0 | nM | 491.68 | CCN(CCCCCCn1nc(-c2cc(N(C)C)ccc2O)ccc1=O)Cc1ccccc1N(C)C | Homo sapiens | CHEMBL5133652 | single protein format |
| CHEMBL95 | |
Ki | = | 152.28 | nM | 198.27 | Nc1c2c(nc3ccccc13)CCCC2 | Homo sapiens | CHEMBL4368211 | single protein format |