Q04760 | LGUL_HUMAN | Lactoylglutathione lyase (GLO1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00903 | Glyoxalase - Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily | 32~174 |
3D structures mapped by conservation among orthologs
[ Domain: "Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase" // Glyoxalase_1 ]
[ Domain: "Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase" // Glyoxalase_6 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2203964 |  |
IC50 | = | 11.0 | nM | 375.43 | COCCCn1ccc2cc(-c3cc(-c4ccccc4)cc(=O)n3O)cnc21 | Homo sapiens | CHEMBL2212266 | assay format |
| CHEMBL2203978 |  |
IC50 | = | 14.0 | nM | 361.4 | COCCn1ccc2cc(-c3cc(-c4ccccc4)cc(=O)n3O)cnc21 | Homo sapiens | CHEMBL2212266 | assay format |
| CHEMBL3220929 |  |
IC50 | = | 26.4 | nM | 586.65 | C#CCCCC(=O)Nc1ccc(C(=O)c2ccc(Nc3ncc(F)c(Nc4ccccc4NS(C)(=O)=O)n3)cc2)cc1 | Homo sapiens | CHEMBL3224397 | single protein format |
| CHEMBL2203976 |  |
IC50 | = | 40.0 | nM | 436.47 | NC(=O)c1cccc(Cn2ccc3cc(-c4cc(-c5ccccc5)cc(=O)n4O)cnc32)c1 | Homo sapiens | CHEMBL2212266 | assay format |
| CHEMBL3220931 |  |
IC50 | = | 45.8 | nM | 465.51 | CS(=O)(=O)Nc1ccccc1Nc1nc(Nc2ccc(Oc3ccccc3)cc2)ncc1F | Homo sapiens | CHEMBL3224397 | single protein format |
| CHEMBL3220930 |  |
IC50 | = | 51.3 | nM | 507.55 | CS(=O)(=O)Nc1ccccc1Nc1nc(Nc2ccc(C(=O)OCc3ccccc3)cc2)ncc1F | Homo sapiens | CHEMBL3224397 | single protein format |
| CHEMBL3220932 |  |
IC50 | = | 53.9 | nM | 407.86 | CS(=O)(=O)Nc1ccccc1Nc1nc(Nc2ccc(Cl)cc2)ncc1F | Homo sapiens | CHEMBL3224397 | single protein format |
| CHEMBL2203975 |  |
IC50 | = | 250.0 | nM | 302.33 | O=c1cc(-c2ccccc2)cc(-c2ccc3[nH]ccc3c2)n1O | Homo sapiens | CHEMBL2212266 | assay format |
| CHEMBL2203963 |  |
IC50 | = | 260.0 | nM | 360.41 | COCCn1ccc2cc(-c3cc(-c4ccccc4)cc(=O)n3O)ccc21 | Homo sapiens | CHEMBL2212266 | assay format |
| CHEMBL2203974 |  |
IC50 | = | 280.0 | nM | 303.32 | O=c1cc(-c2ccccc2)cc(-c2cnc3[nH]ccc3c2)n1O | Homo sapiens | CHEMBL2212266 | assay format |
| CHEMBL2203965 |  |
IC50 | = | 300.0 | nM | 374.44 | COCCCn1ccc2cc(-c3cc(-c4ccccc4)cc(=O)n3O)ccc21 | Homo sapiens | CHEMBL2212266 | assay format |
| CHEMBL2203966 |  |
IC50 | = | 300.0 | nM | 359.43 | CCCCn1ccc2cc(-c3cc(-c4ccccc4)cc(=O)n3O)cnc21 | Homo sapiens | CHEMBL2212266 | assay format |
| CHEMBL4559294 |  |
IC50 | = | 370.0 | nM | 395.87 | O=S(=O)(Nc1ccc(-c2cccc(Cl)c2)c2cccnc12)c1ccccn1 | Homo sapiens | CHEMBL4370193 | assay format |
| CHEMBL4516514 |  |
IC50 | = | 460.0 | nM | 449.53 | COc1cc(CCc2cc(NS(=O)(=O)c3ccccn3)c3ncccc3c2)cc(OC)c1 | Homo sapiens | CHEMBL4370193 | assay format |
| CHEMBL4543065 |  |
IC50 | = | 480.0 | nM | 395.87 | O=S(=O)(Nc1ccc(-c2ccc(Cl)cc2)c2cccnc12)c1ccccn1 | Homo sapiens | CHEMBL4370193 | assay format |
| CHEMBL2203977 |  |
IC50 | = | 480.0 | nM | 435.48 | NC(=O)c1cccc(Cn2ccc3cc(-c4cc(-c5ccccc5)cc(=O)n4O)ccc32)c1 | Homo sapiens | CHEMBL2212266 | assay format |
| CHEMBL4539074 |  |
IC50 | = | 500.0 | nM | 361.43 | O=S(=O)(Nc1ccc(-c2ccccc2)c2cccnc12)c1ccccn1 | Homo sapiens | CHEMBL4370193 | assay format |
| CHEMBL2203967 |  |
IC50 | = | 510.0 | nM | 373.46 | CCCCCn1ccc2cc(-c3cc(-c4ccccc4)cc(=O)n3O)cnc21 | Homo sapiens | CHEMBL2212266 | assay format |
| CHEMBL4457949 |  |
IC50 | = | 540.0 | nM | 430.32 | O=S(=O)(Nc1ccc(-c2ccc(Cl)c(Cl)c2)c2cccnc12)c1ccccn1 | Homo sapiens | CHEMBL4370193 | assay format |
| CHEMBL164 |  |
IC50 | = | 560.0 | nM | 318.24 | O=c1c(O)c(-c2cc(O)c(O)c(O)c2)oc2cc(O)cc(O)c12 | Homo sapiens | CHEMBL967534 | assay format |