Q04759 | KPCT_HUMAN | Protein kinase C theta type (PRKCQ)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 382~634 | |
| PF00130 | C1_1 - Phorbol esters/diacylglycerol binding domain (C1 domain) | 160~210 | |
| PF00130 | C1_1 - Phorbol esters/diacylglycerol binding domain (C1 domain) | 232~283 | |
| PF00433 | Pkinase_C - Protein kinase C terminal domain | 655~696 | |
| PF21494 | PKC_C2 - Protein kinase C delta/epsilon/eta/theta, C2 domain | 4~113 |
3D structures mapped by conservation among orthologs
[ Domain: "C2 domain" // KOG0694 ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Domain: "Cysteine-rich domain" // C1_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4082370 |  |
IC50 | = | 0.086 | nM | 388.86 | CCOc1ccnc2[nH]c(=O)n(-c3nc(N4CCCNCC4)ccc3Cl)c12 | Homo sapiens | CHEMBL4017958 | assay format |
| CHEMBL2151411 |  |
IC50 | = | 0.1 | nM | 452.52 | Cc1cccc2c(C3=C(c4nc(N5CCN(C)CC5)nc5ccccc45)C(=O)NC3=O)c[nH]c12 | Homo sapiens | CHEMBL2156016 | single protein format |
| CHEMBL4578497 |  |
IC50 | = | 0.1 | nM | 569.68 | N#Cc1cnc(NCc2ccccc2OC(F)(F)F)nc1NCC12CC3CC(C1)C(N[C@H]1CC[C@H](N)CC1)C(C3)C2 | Homo sapiens | CHEMBL4370498 | single protein format |
| CHEMBL3920517 |  |
IC50 | = | 0.13 | nM | 573.58 | Nc1ncc(-c2nc(N3CCOCC3)ccc2C(F)(F)F)nc1C(=O)Nc1ncccc1N1CCC(N)(CO)CC1 | Homo sapiens | CHEMBL3889159 | single protein format |
| CHEMBL3921551 |  |
IC50 | = | 0.13 | nM | 506.92 | CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3nccc(Cl)c3C(F)(F)F)cnc2N)CC1 | Homo sapiens | CHEMBL3889159 | single protein format |
| CHEMBL3586039 |  |
IC50 | = | 0.14 | nM | 441.52 | CCN1CCC[C@@H](CNc2nc(Nc3cc(OC)cc(-n4nnnc4C)c3)ncc2F)C1 | Homo sapiens | CHEMBL3587275 | single protein format |
| CHEMBL3893533 |  |
IC50 | = | 0.16 | nM | 542.57 | Nc1ncc(-c2cc(N3CCOCC3)cc(C(F)(F)F)c2)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 | Homo sapiens | CHEMBL3889159 | single protein format |
| CHEMBL4065996 |  |
IC50 | = | 0.18 | nM | 517.55 | CC(C)(C)OC(=O)N1CCN(c2ccc([N+](=O)[O-])c(-n3c(=O)[nH]c4ncccc43)n2)C(c2ccccc2)C1 | Homo sapiens | CHEMBL4017958 | assay format |
| CHEMBL3966595 |  |
IC50 | = | 0.2 | nM | 525.62 | Nc1ncc(-c2nc(N3CCOCC3)cc3ccccc23)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 | Homo sapiens | CHEMBL3889159 | single protein format |
| CHEMBL4547465 |  |
IC50 | = | 0.23 | nM | 575.83 | CC(C)Sc1ncccc1CNc1ncc(C#N)c(NCC23CC4CC(C2)C(NC[C@H]2CC[C@H](O)CC2)C(C4)C3)n1 | Homo sapiens | CHEMBL4370498 | single protein format |
| CHEMBL3982497 |  |
IC50 | = | 0.23 | nM | 428.5 | Nc1ncc(-c2cccc3[nH]ccc23)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 | Homo sapiens | CHEMBL3889159 | single protein format |
| CHEMBL3907088 |  |
IC50 | = | 0.24 | nM | 454.93 | CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3nc(N)ncc3Cl)cnc2N)CC1 | Homo sapiens | CHEMBL3889159 | single protein format |
| CHEMBL3943813 |  |
IC50 | = | 0.25 | nM | 388.48 | Nc1ncc(-c2ccccc2)nc1C(=O)Nc1ccccc1N1CCC(N)CC1 | Homo sapiens | CHEMBL3889159 | single protein format |
| CHEMBL3984070 |  |
IC50 | = | 0.27 | nM | 544.54 | Nc1ncc(-c2nc(N3CCOCC3)ncc2C(F)(F)F)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 | Homo sapiens | CHEMBL3889159 | single protein format |
| CHEMBL3937993 |  |
IC50 | = | 0.27 | nM | 466.48 | CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3nc(C(N)=O)ncc3F)cnc2N)CC1 | Homo sapiens | CHEMBL3889159 | single protein format |
| CHEMBL571581 |  |
IC50 | = | 0.28 | nM | 476.58 | Cc1c(Nc2c(C#N)cncc2-c2cc3cc(CN4CCN(C)CC4)ccc3o2)ccc2[nH]ccc12 | Homo sapiens | CHEMBL1047183 | single protein format |
| CHEMBL3987185 |  |
IC50 | = | 0.29 | nM | 532.53 | CCOCC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3ncccc3OC(F)(F)F)cnc2N)CC1 | Homo sapiens | CHEMBL3889159 | single protein format |
| CHEMBL3892099 |  |
IC50 | = | 0.3 | nM | 539.64 | CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3nc(N4CCOCC4)cc4ccccc34)cnc2N)CC1 | Homo sapiens | CHEMBL3889159 | single protein format |
| CHEMBL1082225 |  |
IC50 | = | 0.32 | nM | 449.56 | Cc1c(Nc2c(C#N)cncc2/C=C/c2cccc(CN3CCNCC3)n2)ccc2[nH]ccc12 | Homo sapiens | CHEMBL1105142 | single protein format |
| CHEMBL3586038 |  |
IC50 | = | 0.32 | nM | 427.49 | COc1cc(Nc2ncc(F)c(NC[C@@H]3CCCN(C)C3)n2)cc(-n2nnnc2C)c1 | Homo sapiens | CHEMBL3587275 | single protein format |