Q04721 | NOTC2_HUMAN | Neurogenic locus notch homolog protein 2 (NOTCH2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00008 | EGF - EGF-like domain | 68~99 | |
| PF00008 | EGF - EGF-like domain | 113~140 | |
| PF00008 | EGF - EGF-like domain | 148~177 | |
| PF00008 | EGF - EGF-like domain | 379~410 | |
| PF00008 | EGF - EGF-like domain | 460~489 | |
| PF00008 | EGF - EGF-like domain | 498~527 | |
| PF00008 | EGF - EGF-like domain | 536~564 | |
| PF00008 | EGF - EGF-like domain | 611~640 | |
| PF00008 | EGF - EGF-like domain | 649~678 | |
| PF00008 | EGF - EGF-like domain | 761~789 | |
| PF00008 | EGF - EGF-like domain | 799~829 | |
| PF00008 | EGF - EGF-like domain | 837~869 | |
| PF00008 | EGF - EGF-like domain | 915~944 | |
| PF00008 | EGF - EGF-like domain | 953~982 | |
| PF00008 | EGF - EGF-like domain | 1029~1059 | |
| PF00008 | EGF - EGF-like domain | 1067~1097 | |
| PF00008 | EGF - EGF-like domain | 1120~1145 | |
| PF00008 | EGF - EGF-like domain | 1153~1182 | |
| PF00008 | EGF - EGF-like domain | 1229~1260 | |
| PF00008 | EGF - EGF-like domain | 1308~1341 | |
| PF00023 | Ank - Ankyrin repeat | 1877~1908 | |
| PF00023 | Ank - Ankyrin repeat | 2011~2040 | |
| PF00066 | Notch - LNR domain | 1423~1456 | |
| PF00066 | Notch - LNR domain | 1463~1497 | |
| PF00066 | Notch - LNR domain | 1501~1534 | |
| PF06816 | NOD - NOTCH protein | 1539~1594 | |
| PF07645 | EGF_CA - Calcium-binding EGF domain | 182~214 | |
| PF07645 | EGF_CA - Calcium-binding EGF domain | 298~331 | |
| PF07645 | EGF_CA - Calcium-binding EGF domain | 415~449 | |
| PF07645 | EGF_CA - Calcium-binding EGF domain | 873~904 | |
| PF07684 | NODP - NOTCH protein | 1618~1671 | |
| PF12661 | hEGF - Human growth factor-like EGF | 269~288 | |
| PF12661 | hEGF - Human growth factor-like EGF | 347~367 | |
| PF12661 | hEGF - Human growth factor-like EGF | 579~599 | |
| PF12661 | hEGF - Human growth factor-like EGF | 691~711 | |
| PF12661 | hEGF - Human growth factor-like EGF | 729~749 | |
| PF12661 | hEGF - Human growth factor-like EGF | 996~1017 | |
| PF12661 | hEGF - Human growth factor-like EGF | 1196~1216 | |
| PF12796 | Ank_2 - Ankyrin repeats (3 copies) | 1924~2006 |
3D structures mapped by conservation among orthologs
[ Domain: "Notch heterodimerization domain" // NOD ]
[ Domain: "EGF/Laminin" // hEGF_2 ]
[ Domain: "Lin12/Notch repeat" // Notch ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3410161 |  |
IC50 | = | 1.0 | nM | 536.55 | CN1C(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccccc2)N=C(c2ccccc2)c2ccccc21 | Homo sapiens | CHEMBL3412055 | cell-based format |