ProtHub

Q04721 | NOTC2_HUMAN | Neurogenic locus notch homolog protein 2 (NOTCH2)

Helixβ‑strandTurn secondary structure

Accession	Domain	Range
PF00008	EGF	68–99
PF00008	EGF	113–140
PF00008	EGF	148–177
PF00008	EGF	379–410
PF00008	EGF	460–489
PF00008	EGF	498–527
PF00008	EGF	536–564
PF00008	EGF	611–640
PF00008	EGF	649–678
PF00008	EGF	761–789
PF00008	EGF	799–829
PF00008	EGF	837–869
PF00008	EGF	915–944
PF00008	EGF	953–982
PF00008	EGF	1029–1059
PF00008	EGF	1067–1097
PF00008	EGF	1120–1145
PF00008	EGF	1153–1182
PF00008	EGF	1229–1260
PF00008	EGF	1308–1341
PF00023	Ank	1877–1908
PF00023	Ank	2011–2040
PF00066	Notch	1423–1456
PF00066	Notch	1463–1497
PF00066	Notch	1501–1534
PF06816	NOD	1539–1594
PF07645	EGF_CA	182–214
PF07645	EGF_CA	298–331
PF07645	EGF_CA	415–449
PF07645	EGF_CA	873–904
PF07684	NODP	1618–1671
PF12661	hEGF	269–288
PF12661	hEGF	347–367
PF12661	hEGF	579–599
PF12661	hEGF	691–711
PF12661	hEGF	729–749
PF12661	hEGF	996–1017
PF12661	hEGF	1196–1216
PF12796	Ank_2	1924–2006

3D structures mapped by conservation among orthologs

[ Alpha Fold Model ] (go)

Known binders annotated in ChEMBL

Only the first 20 rows are shown.

molecule_chembl_id	structure	assay_type	relation	value	unit	mol_wt	smiles	organism	assay_chembl_id	bao_label
CHEMBL3410161		IC50	=	1.0	nM	536.55	CN1C(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccccc2)N=C(c2ccccc2)c2ccccc21	Homo sapiens	CHEMBL3412055	cell-based format