Q04206 | TF65_HUMAN | Transcription factor p65 (RELA)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00554 | RHD_DNA_bind - Rel homology DNA-binding domain | 21~186 | |
| PF16179 | RHD_dimer - Rel homology dimerisation domain | 195~291 |
3D structures mapped by conservation among orthologs
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // RHD_dimer ]
[ Domain: "Common fold of diphtheria toxin/transcription factors/cytochrome f" // RHD_DNA_bind ]
[ Domain: "winged" // IRF ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL169 |  |
IC50 | = | 31.0 | nM | 456.71 | C[C@H]1[C@H](C)CC[C@]2(C(=O)O)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@H]12 | Homo sapiens | CHEMBL4235015 | single protein format |
| CHEMBL939 |  |
IC50 | = | 55.0 | nM | 446.91 | COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 | Homo sapiens | CHEMBL4684706 | cell-based format |
| CHEMBL438139 |  |
IC50 | = | 80.0 | nM | 505.57 | COc1ccc([C@@]23Oc4cc(OC)cc(OC)c4[C@]2(O)[C@H](O)[C@H](C(=O)N(C)C)[C@H]3c2ccccc2)cc1 | Homo sapiens | CHEMBL1100043 | single protein format |
| CHEMBL4778826 |  |
IC50 | = | 134.0 | nM | 383.83 | COc1ccc(/C=C/C(=O)c2nnn(-c3ccc(Cl)cc3)c2C)cc1OC | Homo sapiens | CHEMBL4684706 | cell-based format |
| CHEMBL218562 |  |
IC50 | = | 150.0 | nM | 228.27 | COc1ccc(/C=C/c2ccccc2F)cc1 | Homo sapiens | CHEMBL3705677 | single protein format |
| CHEMBL83880 |  |
IC50 | = | 150.0 | nM | 223.32 | CN(C)c1ccc(/C=C/c2ccccc2)cc1 | Homo sapiens | CHEMBL3705677 | single protein format |
| CHEMBL384590 |  |
IC50 | = | 230.0 | nM | 490.84 | CCCCCCCCCCCCCCCCS(=O)(=O)NCCCNCCCCNCCCN | Homo sapiens | CHEMBL910807 | cell-based format |
| CHEMBL1077979 |  |
IC50 | = | 250.0 | nM | 362.38 | COc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O | Homo sapiens | CHEMBL1804152 | cell-based format |
| CHEMBL214521 |  |
IC50 | = | 300.0 | nM | 224.3 | CCOc1ccc(/C=C/c2ccccc2)cc1 | Homo sapiens | CHEMBL3705677 | single protein format |
| CHEMBL218163 |  |
IC50 | = | 310.0 | nM | 406.68 | CCCCCCCCCCS(=O)(=O)NCCCNCCCCNCCCN | Homo sapiens | CHEMBL910807 | cell-based format |
| CHEMBL218434 |  |
IC50 | = | 340.0 | nM | 434.74 | CCCCCCCCCCCCS(=O)(=O)NCCCNCCCCNCCCN | Homo sapiens | CHEMBL910807 | cell-based format |
| CHEMBL215186 |  |
IC50 | = | 500.0 | nM | 242.27 | COc1ccc(/C=C/c2cccc(O)c2O)cc1 | Homo sapiens | CHEMBL3705677 | single protein format |
| CHEMBL271669 |  |
IC50 | = | 600.0 | nM | 296.35 | Cc1ccc2c(c1)-c1ccc3cccnc3c1NS2(=O)=O | Homo sapiens | CHEMBL945842 | single protein format |
| CHEMBL215583 |  |
IC50 | = | 600.0 | nM | 240.3 | COc1ccc(/C=C/c2cccc(OC)c2)cc1 | Homo sapiens | CHEMBL3705677 | single protein format |
| CHEMBL215432 |  |
IC50 | = | 600.0 | nM | 242.27 | COc1ccc(/C=C/c2ccc(O)c(O)c2)cc1 | Homo sapiens | CHEMBL3705677 | single protein format |
| CHEMBL1801948 |  |
IC50 | = | 750.0 | nM | 348.35 | C[C@H]1C/C=C\C(=O)[C@@H](O)[C@@H](O)C/C=C/c2cc(O)cc(O)c2C(=O)O1 | Homo sapiens | CHEMBL1804152 | cell-based format |
| CHEMBL214885 |  |
IC50 | = | 800.0 | nM | 224.3 | COc1ccc(/C=C/c2cccc(C)c2)cc1 | Homo sapiens | CHEMBL3705677 | single protein format |
| CHEMBL273149 |  |
IC50 | = | 900.0 | nM | 340.4 | COc1cc2ccc(C)nc2c2c1-c1cc(C)ccc1S(=O)(=O)N2 | Homo sapiens | CHEMBL945842 | single protein format |
| CHEMBL383922 |  |
IC50 | = | 900.0 | nM | 224.3 | COc1ccc(/C=C/c2ccc(C)cc2)cc1 | Homo sapiens | CHEMBL3705677 | single protein format |
| CHEMBL402638 |  |
IC50 | = | 900.0 | nM | 343.36 | Cc1ccc2cccc(NS(=O)(=O)c3cccc([N+](=O)[O-])c3)c2n1 | Homo sapiens | CHEMBL945842 | single protein format |