3D structures mapped by conservation among orthologs

[ Domain: "Snake toxin-like" // UPAR_LY6 ]

 PyMOL session

[ Domain: "Snake toxin-like" // UPAR_LY6_1 ]

 PyMOL session

[ Alpha Fold Model ] (go)

Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV

Only the first 20 rows are shown.

molecule_chembl_id	structure	assay_type	relation	value	unit	mol_wt	smiles	organism	assay_chembl_id	bao_label
CHEMBL4753144		IC50	=	500.0	nM	418.49	O=C(c1cc(-c2cccc(F)c2)nc2c(-c3cccs3)cccc12)N1CCOCC1	Homo sapiens	CHEMBL4679628	cell-based format
CHEMBL4791246		IC50	=	500.0	nM	400.5	O=C(c1cc(-c2ccccc2)nc2c(-c3cccs3)cccc12)N1CCOCC1	Homo sapiens	CHEMBL4679628	cell-based format
CHEMBL2206684		Ki	=	0.000288	nM	432.49	C=CCn1c(CN2C3=Nc4ccccc4C(=O)NC3=Nc3ccccc32)nc2ccccc21	Homo sapiens	CHEMBL2210436	single protein format
CHEMBL2206694		Ki	=	0.000589	nM	313.36	N#Cc1cc(-c2ccccc2)n(Cc2nc3ccccc3[nH]2)c1N	Homo sapiens	CHEMBL2210436	single protein format
CHEMBL2206696		Ki	=	0.001	nM	351.41	Nc1c(-c2nc3ccccc3[nH]2)cc(-c2ccccc2)n1-c1ccncc1	Homo sapiens	CHEMBL2210436	single protein format
CHEMBL2206680		Ki	=	0.00153	nM	390.45	Nc1c(-c2nc3ccccc3[nH]2)cc(-c2ccccc2)n1-c1nc2ccccc2[nH]1	Homo sapiens	CHEMBL2210436	single protein format
CHEMBL2206685		Ki	=	0.0017	nM	478.51	CCOC(=O)Cn1c(CN2C3=Nc4ccccc4C(=O)NC3=Nc3ccccc32)nc2ccccc21	Homo sapiens	CHEMBL2210436	single protein format
CHEMBL2206681		Ki	=	0.00217	nM	404.48	Nc1c(-c2nc3ccccc3[nH]2)cc(-c2ccccc2)n1Cc1nc2ccccc2[nH]1	Homo sapiens	CHEMBL2210436	single protein format
CHEMBL2206691		Ki	=	0.00227	nM	293.76	N#Cc1cc(-c2ccccc2)n(-c2cccc(Cl)c2)c1N	Homo sapiens	CHEMBL2210436	single protein format
CHEMBL2206693		Ki	=	0.00302	nM	299.34	N#Cc1cc(-c2ccccc2)n(-c2nc3ccccc3[nH]2)c1N	Homo sapiens	CHEMBL2210436	single protein format
CHEMBL2206690		Ki	=	0.00327	nM	338.21	N#Cc1cc(-c2ccccc2)n(-c2ccc(Br)cc2)c1N	Homo sapiens	CHEMBL2210436	single protein format
CHEMBL2206692		Ki	=	0.00329	nM	293.76	N#Cc1cc(-c2ccccc2)n(-c2ccc(Cl)cc2)c1N	Homo sapiens	CHEMBL2210436	single protein format
CHEMBL2206689		Ki	=	0.00411	nM	338.21	N#Cc1cc(-c2ccccc2)n(-c2cccc(Br)c2)c1N	Homo sapiens	CHEMBL2210436	single protein format
CHEMBL2206699		Ki	=	0.0044	nM	384.87	Nc1c(-c2nc3ccccc3[nH]2)cc(-c2ccccc2)n1-c1cccc(Cl)c1	Homo sapiens	CHEMBL2210436	single protein format
CHEMBL2206700		Ki	=	0.00445	nM	384.87	Nc1c(-c2nc3ccccc3[nH]2)cc(-c2ccccc2)n1-c1ccc(Cl)cc1	Homo sapiens	CHEMBL2210436	single protein format
CHEMBL2206683		Ki	=	0.00636	nM	392.42	O=C1NC2=Nc3ccccc3N(Cc3nc4ccccc4[nH]3)C2=Nc2ccccc21	Homo sapiens	CHEMBL2210436	single protein format
CHEMBL2206695		Ki	=	0.00653	nM	351.41	Nc1c(-c2nc3ccccc3[nH]2)cc(-c2ccccc2)n1-c1ccccn1	Homo sapiens	CHEMBL2210436	single protein format
CHEMBL2206688		Ki	=	0.00759	nM	260.3	N#Cc1cc(-c2ccccc2)n(-c2ccncc2)c1N	Homo sapiens	CHEMBL2210436	single protein format
CHEMBL2206698		Ki	=	0.011	nM	429.32	Nc1c(-c2nc3ccccc3[nH]2)cc(-c2ccccc2)n1-c1ccc(Br)cc1	Homo sapiens	CHEMBL2210436	single protein format
CHEMBL2206697		Ki	=	0.012	nM	429.32	Nc1c(-c2nc3ccccc3[nH]2)cc(-c2ccccc2)n1-c1cccc(Br)c1	Homo sapiens	CHEMBL2210436	single protein format