Q03181 | PPARD_HUMAN | Peroxisome proliferator-activated receptor delta (PPARD)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00104 | Hormone_recep - Ligand-binding domain of nuclear hormone receptor | 239~420 | |
| PF00105 | zf-C4 - Double treble clef zinc finger, C4 type | 73~139 |
3D structures mapped by conservation among orthologs
[ Domain: "Nuclear receptor ligand-binding domain" // Hormone_recep_1 ]
[ Domain: "LIM domain-like" // zf-C4 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL38943 |  |
IC50 | = | 1.0 | nM | 453.51 | Cc1cc(SCc2sc(-c3ccc(C(F)(F)F)cc3)nc2C)ccc1OCC(=O)O | Homo sapiens | CHEMBL759401 | single protein format |
| CHEMBL38508 |  |
IC50 | = | 1.0 | nM | 471.5 | Cc1cc(SCc2sc(-c3ccc(C(F)(F)F)c(F)c3)nc2C)ccc1OCC(=O)O | Homo sapiens | CHEMBL759401 | single protein format |
| CHEMBL234659 |  |
IC50 | = | 1.7 | nM | 492.52 | COc1cc(OCC(=O)O)c(C)cc1SCc1ccc(OCc2ccc(C(F)(F)F)cc2)cc1 | Homo sapiens | CHEMBL896362 | single protein format |
| CHEMBL232400 |  |
IC50 | = | 1.7 | nM | 506.52 | O=C(O)COc1ccc(SCc2cc(F)ccc2OCc2ccc(C(F)(F)F)cc2)c2c1CCC2 | Homo sapiens | CHEMBL896362 | single protein format |
| CHEMBL241299 |  |
IC50 | = | 2.0 | nM | 439.94 | Cc1cc(OCC[C@@H](C)Oc2ccc(Cl)cc2-c2ccccn2)ccc1CCC(=O)O | Homo sapiens | CHEMBL885567 | single protein format |
| CHEMBL231690 |  |
IC50 | = | 2.8 | nM | 386.42 | Cc1nc(C(F)(F)F)sc1CSc1ccc2c(ccn2CC(=O)O)c1 | Homo sapiens | CHEMBL896466 | single protein format |
| CHEMBL238970 |  |
IC50 | = | 3.0 | nM | 487.52 | CCc1cc(OCC[C@@H](C)Oc2ccc(C(F)(F)F)cc2-c2ccccn2)ccc1CCC(=O)O | Homo sapiens | CHEMBL885567 | single protein format |
| CHEMBL393938 |  |
IC50 | = | 3.0 | nM | 521.92 | Cc1cc(Oc2cccc(CNC(=O)c3ccc(C(F)(F)F)cc3Cl)c2)ccc1OC(C)(C)C(=O)O | Homo sapiens | CHEMBL902598 | single protein format |
| CHEMBL241471 |  |
IC50 | = | 3.0 | nM | 433.55 | CCc1ccc(O[C@H](C)CCOc2ccc(CCC(=O)O)c(C)c2)c(-c2ccccn2)c1 | Homo sapiens | CHEMBL885567 | single protein format |
| CHEMBL289887 |  |
IC50 | = | 3.0 | nM | 437.44 | Cc1cc(SCc2oc(-c3ccc(C(F)(F)F)cc3)nc2C)ccc1OCC(=O)O | Homo sapiens | CHEMBL759401 | single protein format |
| CHEMBL236877 |  |
IC50 | = | 3.0 | nM | 566.37 | Cc1cc(Oc2cccc(CNC(=O)c3ccc(C(F)(F)F)cc3Br)c2)ccc1OC(C)(C)C(=O)O | Homo sapiens | CHEMBL902598 | single protein format |
| CHEMBL236664 |  |
IC50 | = | 3.0 | nM | 501.5 | Cc1cc(Oc2cccc(CNC(=O)c3ccc(C(F)(F)F)cc3C)c2)ccc1OC(C)(C)C(=O)O | Homo sapiens | CHEMBL902598 | single protein format |
| CHEMBL241286 |  |
IC50 | = | 3.0 | nM | 439.58 | CCc1ccc(O[C@H](C)CCOc2ccc(CCC(=O)O)c(C)c2)c(-c2cscn2)c1 | Homo sapiens | CHEMBL885567 | single protein format |
| CHEMBL212911 |  |
IC50 | = | 3.0 | nM | 460.57 | CCc1ccc(O[C@H](C)CCOc2ccc(CCC(=O)O)c(C)c2)c(C(=O)c2ccccc2)c1 | Homo sapiens | CHEMBL911540 | single protein format |
| CHEMBL238152 |  |
IC50 | = | 3.0 | nM | 490.99 | Cc1cc(Oc2cccc(CNC(=O)c3c(C)c4cc(Cl)ccc4n3C)c2)ccc1CCC(=O)O | Homo sapiens | CHEMBL902598 | single protein format |
| CHEMBL235143 |  |
IC50 | = | 3.0 | nM | 476.96 | Cc1cc(Oc2cccc(CNC(=O)c3[nH]c4ccc(Cl)cc4c3C)c2)ccc1CCC(=O)O | Homo sapiens | CHEMBL902598 | single protein format |
| CHEMBL399417 |  |
IC50 | = | 3.0 | nM | 476.96 | Cc1cc(Oc2cccc(CNC(=O)c3cc4cc(Cl)ccc4n3C)c2)ccc1CCC(=O)O | Homo sapiens | CHEMBL902598 | single protein format |
| CHEMBL241479 |  |
IC50 | = | 3.0 | nM | 447.58 | CCc1ccc(O[C@H](C)CCOc2ccc(CCC(=O)O)c(CC)c2)c(-c2ccccn2)c1 | Homo sapiens | CHEMBL885567 | single protein format |
| CHEMBL237484 |  |
IC50 | = | 3.0 | nM | 462.93 | Cc1cc(Oc2cccc(CNC(=O)c3cc4ccc(Cl)cc4[nH]3)c2)ccc1CCC(=O)O | Homo sapiens | CHEMBL902598 | single protein format |
| CHEMBL237277 |  |
IC50 | = | 3.0 | nM | 462.93 | Cc1cc(Oc2cccc(CNC(=O)c3cc4cc(Cl)ccc4[nH]3)c2)ccc1CCC(=O)O | Homo sapiens | CHEMBL902598 | single protein format |