Q03164 | KMT2A_HUMAN | Histone-lysine N-methyltransferase 2A (KMT2A)
Helixβ‑strandTurn secondary structure
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00628 | PHD | 1482–1530 | |
| PF00628 | PHD | 1569–1624 | |
| PF00856 | SET | 3840–3945 | |
| PF02008 | zf-CXXC | 1148–1194 | |
| PF05964 | FYRN | 2019–2074 | |
| PF05965 | FYRC | 3669–3748 | |
| PF13771 | zf-HC5HC2H | 1900–1978 |
3D structures mapped by conservation among orthologs
[ Domain: "SET domain-like" // SET ]
[ Domain: "Bromodomain" // Bromodomain ]
[ Domain: "CXXC domain" // zf-CXXC ]
[ Domain: "FYVE/PHD zinc finger" // PHD ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5183439 |  |
IC50 | = | 20.0 | nM | 481.38 | Cc1ncccc1-c1cc(Cn2ccn(C)c2=O)cc(C(=O)NCc2cc(Cl)cc(Cl)c2)c1 | Homo sapiens | CHEMBL5151853 | single protein format |
| CHEMBL5172154 |  |
IC50 | = | 190.0 | nM | 553.08 | Cc1c(F)c(N)cc(C(=O)Nc2cc(-c3ccc(C(=O)NCCCN)cc3)ccc2N2CCN(C)CC2)c1Cl | Homo sapiens | CHEMBL5151853 | single protein format |
| CHEMBL3798088 |  |
IC50 | = | 320.0 | nM | 586.74 | CC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@](C)(NC(=O)C(C)C)CCCCNC(=O)[C@@H](c2ccccc2)NC1=O | Homo sapiens | CHEMBL3801644 | cell-based format |
| CHEMBL5094242 |  |
IC50 | = | 780.0 | nM | 483.98 | CN1CCN(c2cc(F)c(-c3ccc(C(=O)N(C)C)cc3)cc2Nc2ncnc(Cl)c2N)CC1 | Homo sapiens | CHEMBL5034293 | single protein format |