Q03111 | ENL_HUMAN | Protein ENL (MLLT1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF03366 | YEATS - YEATS family | 28~107 | |
| PF17793 | AHD - ANC1 homology domain (AHD) | 495~555 |
3D structures mapped by conservation among orthologs
[ Domain: "C2 domain" // YEATS ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5400413 |  |
IC50 | = | 10.7 | nM | 389.46 | Cc1noc2cc(C(=O)Nc3ccc4[nH]c(CN5CCC[C@@H]5C)nc4c3)ccc12 | Homo sapiens | CHEMBL5321801 | cell-based format |
| CHEMBL5423431 |  |
IC50 | = | 14.5 | nM | 487.61 | C[C@H]1CCCN1Cc1nc2cc(NC(=O)c3ccc4c(cnn4CCN4CCOCC4)c3)ccc2[nH]1 | Homo sapiens | CHEMBL5321801 | cell-based format |
| CHEMBL5438748 |  |
IC50 | = | 15.4 | nM | 465.56 | C[C@H]1CCCN1Cc1nc2cc(NC(=O)c3ccc4c(c3)c3ccccc3c(=O)n4C)ccc2[nH]1 | Homo sapiens | CHEMBL5321801 | cell-based format |
| CHEMBL5397340 |  |
IC50 | = | 17.0 | nM | 430.56 | CCCCn1ncc2cc(C(=O)Nc3ccc4[nH]c(CN5CCC[C@@H]5C)nc4c3)ccc21 | Homo sapiens | CHEMBL5321801 | cell-based format |
| CHEMBL5411777 |  |
IC50 | = | 17.2 | nM | 417.52 | C[C@H]1CCCN1Cc1nc2cc(NC(=O)c3ccc4nn(CCN)cc4c3)ccc2[nH]1 | Homo sapiens | CHEMBL5321801 | cell-based format |
| CHEMBL5404010 |  |
IC50 | = | 18.9 | nM | 402.5 | CCn1ncc2cc(C(=O)Nc3ccc4[nH]c(CN5CCC[C@@H]5C)nc4c3)ccc21 | Homo sapiens | CHEMBL5321801 | cell-based format |
| CHEMBL5427068 |  |
IC50 | = | 19.2 | nM | 521.63 | C[C@H]1CCCN1Cc1nc2cc(NC(=O)c3ccc4c(cnn4CCNC(=O)c4ccccc4)c3)ccc2[nH]1 | Homo sapiens | CHEMBL5321801 | cell-based format |
| CHEMBL5416453 |  |
IC50 | = | 22.0 | nM | 419.48 | C[C@H]1CCCN1Cc1nc2cc(NC(=O)N3C(CO)C(O)C(O)C3CO)ccc2[nH]1 | Homo sapiens | CHEMBL5321801 | cell-based format |
| CHEMBL5430847 |  |
IC50 | = | 22.1 | nM | 483.55 | C[C@H]1CCCN1Cc1nc2cc(NC(=O)c3ccc4c(c3)c3cc(F)ccc3c(=O)n4C)ccc2[nH]1 | Homo sapiens | CHEMBL5321801 | cell-based format |
| CHEMBL5418436 |  |
IC50 | = | 25.0 | nM | 496.64 | O=C(NC1CCC1)c1ccc2nc(-c3cccc(NS(=O)(=O)NCCN4CCCCC4)c3)cn2c1 | Homo sapiens | CHEMBL5321825 | cell-based format |
| CHEMBL5400474 |  |
IC50 | = | 28.2 | nM | 417.52 | C[C@H]1CCCN1Cc1nc2cc(NC(=O)c3ccc4c(cnn4CCN)c3)ccc2[nH]1 | Homo sapiens | CHEMBL5321801 | cell-based format |
| CHEMBL5421344 |  |
IC50 | = | 31.8 | nM | 465.56 | C[C@H]1CCCN1Cc1nc2cc(NC(=O)c3ccc4c5ccccc5c(=O)n(C)c4c3)ccc2[nH]1 | Homo sapiens | CHEMBL5321801 | cell-based format |
| CHEMBL5414763 |  |
IC50 | = | 32.3 | nM | 563.66 | C[C@H]1CCCN1Cc1nc2cc(NC(=O)c3ccc4c(cnn4CCN4CC(O)C(O)C4C(O)CO)c3)ccc2[nH]1 | Homo sapiens | CHEMBL5321801 | cell-based format |
| CHEMBL5395585 |  |
IC50 | = | 35.3 | nM | 430.56 | CCCCn1cc2cc(C(=O)Nc3ccc4[nH]c(CN5CCC[C@@H]5C)nc4c3)ccc2n1 | Homo sapiens | CHEMBL5321801 | cell-based format |
| CHEMBL5438461 |  |
IC50 | = | 35.4 | nM | 535.65 | Cc1ccccc1C(=O)NCCn1ncc2cc(C(=O)Nc3ccc4[nH]c(CN5CCC[C@@H]5C)nc4c3)ccc21 | Homo sapiens | CHEMBL5321801 | cell-based format |
| CHEMBL5429534 |  |
IC50 | = | 36.7 | nM | 402.5 | CCn1cc2cc(C(=O)Nc3ccc4[nH]c(CN5CCC[C@@H]5C)nc4c3)ccc2n1 | Homo sapiens | CHEMBL5321801 | cell-based format |
| CHEMBL5417838 |  |
IC50 | = | 37.9 | nM | 517.63 | C[C@H]1CCCN1Cc1nc2cc(NC(=O)c3ccc4nn(CCNC(=O)OC(C)(C)C)cc4c3)ccc2[nH]1 | Homo sapiens | CHEMBL5321801 | cell-based format |
| CHEMBL5437942 |  |
IC50 | = | 40.0 | nM | 374.45 | CN1CCC[C@@H]1c1nc2ccc(NC(=O)c3ccc4c(cnn4C)c3)cc2[nH]1 | Homo sapiens | CHEMBL5346777 | single protein format |
| CHEMBL5428707 |  |
IC50 | = | 46.0 | nM | 554.63 | C[C@H]1CCCN1Cc1nc2cc(NC(=O)c3ccc4c(cnn4CCNC(=O)Nc4cccc(F)c4)c3)ccc2[nH]1 | Homo sapiens | CHEMBL5321801 | cell-based format |
| CHEMBL5406254 |  |
IC50 | = | 46.4 | nM | 479.58 | Cc1cccc2c(=O)n(C)c3ccc(C(=O)Nc4ccc5[nH]c(CN6CCC[C@@H]6C)nc5c4)cc3c12 | Homo sapiens | CHEMBL5321801 | cell-based format |