Q02880 | TOP2B_HUMAN | DNA topoisomerase 2-beta (TOP2B)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00204 | DNA_gyraseB - DNA gyrase B | 287~447 | |
| PF00521 | DNA_topoisoIV - DNA gyrase/topoisomerase IV, subunit A | 734~1189 | |
| PF01751 | Toprim - Toprim domain | 477~579 | |
| PF02518 | HATPase_c - Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase | 101~197 | |
| PF08070 | DTHCT - DTHCT (NUC029) region | 1508~1610 | |
| PF16898 | TOPRIM_C - C-terminal associated domain of TOPRIM | 594~732 |
3D structures mapped by conservation among orthologs
[ Domain: "winged" // DNA_topoisoIV_1st ]
[ Domain: "alpha-helical domain in type II DNA topoisomerase" // DNA_topoisoIV_3rd ]
[ Domain: "SSHS domain in type II DNA topoisomerase" // TOPRIM_C ]
[ Domain: "a+b domain in type II DNA topoisomerase" // DNA_topoisoIV_2nd_1 ]
[ Domain: "a+b domain in type II DNA topoisomerase" // DNA_topoisoIV_2nd_1 ]
[ Domain: "Toprim domain" // DNA_gyraseB_C ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5266387 |  |
IC50 | = | 25.8 | nM | 483.55 | Cc1ccc2c(=O)n(Cc3ccccc3)c(SCc3cn(-c4ccc(C(=O)O)cc4)nn3)nc2c1 | Homo sapiens | CHEMBL5228579 | single protein format |
| CHEMBL49442 |  |
IC50 | = | 30.0 | nM | 412.49 | O=C1c2ccccc2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21 | Homo sapiens | CHEMBL4382900 | single protein format |
| CHEMBL44657 |  |
IC50 | = | 69.8 | nM | 588.56 | COc1cc([C@@H]2c3cc4c(cc3[C@@H](O[C@@H]3O[C@@H]5CO[C@@H](C)O[C@H]5[C@H](O)[C@H]3O)[C@H]3COC(=O)[C@H]23)OCO4)cc(OC)c1O | Homo sapiens | CHEMBL4156659 | single protein format |
| CHEMBL4751362 |  |
IC50 | = | 130.0 | nM | 385.45 | Cc1cc(NC2=NC(=O)/C(=C\c3c4ccccc4cc4ccccc34)S2)no1 | Homo sapiens | CHEMBL4672266 | single protein format |
| CHEMBL5408150 |  |
IC50 | = | 550.0 | nM | 577.3 | Cc1[nH]c(C(=O)Nc2ccc(C(N)=O)cc2OCc2ccc(C(=O)NCCN)cc2)c(Cl)c1Cl.Cl.Cl | Homo sapiens | CHEMBL5347793 | single protein format |
| CHEMBL4213218 |  |
IC50 | = | 580.0 | nM | 507.52 | O=C(CN1CCN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1)N/N=C/c1ccccc1O | Homo sapiens | CHEMBL4198805 | single protein format |
| CHEMBL53463 |  |
IC50 | = | 727.0 | nM | 543.53 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | Homo sapiens | CHEMBL4672266 | single protein format |
| CHEMBL4205327 |  |
IC50 | = | 860.0 | nM | 530.56 | O=C(CN1CCN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1)N/N=C/c1cc2ccccc2[nH]1 | Homo sapiens | CHEMBL4198805 | single protein format |