Q02779 | M3K10_HUMAN | Mitogen-activated protein kinase kinase kinase 10 (MAP3K10)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 98~357 | |
| PF14604 | SH3_9 - Variant SH3 domain | 23~77 |
3D structures mapped by conservation among orthologs
[ Domain: "SH3" // SH3_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL388978 |  |
IC50 | = | 2.69 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328503 | single protein format |
| CHEMBL288817 |  |
IC50 | = | 16.0 | nM | 555.59 | COCc1ccc2c(c1)c1c3c(c4c5cc(COC)ccc5n5c4c1n2[C@H]1C[C@](O)(C(=O)OC)[C@]5(C)O1)CNC3=O | Homo sapiens | CHEMBL732489 | single protein format |
| CHEMBL277817 |  |
IC50 | = | 20.0 | nM | 583.64 | CCOCc1ccc2c(c1)c1c3c(c4c5cc(COCC)ccc5n5c4c1n2[C@H]1C[C@](O)(C(=O)OC)[C@]5(C)O1)CNC3=O | Homo sapiens | CHEMBL732489 | single protein format |
| CHEMBL288229 |  |
IC50 | = | 28.0 | nM | 541.63 | CCSCc1ccc2c(c1)c1c3c(c4c5ccccc5n5c4c1n2[C@@]1(C)O[C@@H]5C[C@]1(O)C(=O)OC)C(=O)NC3 | Homo sapiens | CHEMBL732489 | single protein format |
| CHEMBL2436978 |  |
IC50 | = | 42.0 | nM | 421.55 | CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5ccc6[nH]ccc6c5)c4c3)cc2)CC1 | Homo sapiens | CHEMBL2439776 | single protein format |
| CHEMBL416056 |  |
IC50 | = | 45.0 | nM | 467.48 | COC(=O)[C@]1(O)C[C@@H]2O[C@@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL911980 | single protein format |
| CHEMBL4218417 |  |
IC50 | = | 46.0 | nM | 427.5 | CC(C)OCc1ccc2c(c1)c1c3c(c4c5ccccc5[nH]c4c1n2CCO)CNC3=O | Homo sapiens | CHEMBL4199316 | assay format |
| CHEMBL4281823 |  |
IC50 | = | 50.0 | nM | 481.48 | CCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 | Homo sapiens | CHEMBL4261427 | single protein format |
| CHEMBL36891 |  |
IC50 | = | 140.0 | nM | 541.63 | CCSCc1ccc2c(c1)c1c3c(c4c5ccccc5n5c4c1n2[C@H]1C[C@](O)(C(=O)OC)[C@]5(C)O1)CNC3=O | Homo sapiens | CHEMBL732489 | single protein format |
| CHEMBL386636 |  |
IC50 | = | 339.0 | nM | 338.37 | O=C1NC(=O)c2c1c1c(c3[nH]c4ccccc4c23)CCc2ccccc2-1 | Homo sapiens | CHEMBL911980 | single protein format |
| CHEMBL357490 |  |
IC50 | = | 364.0 | nM | 310.36 | O=C1NCc2c1c1c(c3[nH]c4ccccc4c23)Cc2ccccc2-1 | Homo sapiens | CHEMBL911980 | single protein format |
| CHEMBL2171124 |  |
IC50 | = | 452.0 | nM | 451.45 | Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(C(F)(F)F)c2)c2c(N)ncnc21 | Homo sapiens | CHEMBL2172947 | single protein format |
| CHEMBL3393333 |  |
IC50 | = | 767.0 | nM | 440.5 | N#Cc1ccnc(Nc2cc(C3CCN(C4COC4)CC3)cc(N3CCC(F)(F)C3)n2)c1 | Homo sapiens | CHEMBL3395596 | single protein format |