Q02763 | TIE2_HUMAN | Angiopoietin-1 receptor (TEK)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00041 | fn3 - Fibronectin type III domain | 545~630 | |
| PF00041 | fn3 - Fibronectin type III domain | 641~723 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 824~1091 | |
| PF10430 | Ig_Tie2_1 - Tie-2 Ig-like domain 1 | 24~118 |
3D structures mapped by conservation among orthologs
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // Ig_Tie2_1 ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // fn3 ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // fn3_6 ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_3 ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_2 ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Domain: "EGF/Laminin" // hEGF_3 ]
[ Domain: "EGF/Laminin" // hEGF_like_1 ]
[ Domain: "EGF/Laminin" // KOG1226_1st,hEGF_like_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4087541 |  |
IC50 | = | 0.13 | nM | 415.48 | Nc1ncc2ccc(-c3ccc(NC(=S)Nc4ccc5c(c4)OCO5)cc3)cc2n1 | Homo sapiens | CHEMBL3993540 | single protein format |
| CHEMBL4103584 |  |
IC50 | = | 0.16 | nM | 507.46 | Nc1ncc2ccc(-c3ccc(NC(=S)Nc4cc(C(F)(F)F)cc(C(F)(F)F)c4)cc3)cc2n1 | Homo sapiens | CHEMBL3993540 | single protein format |
| CHEMBL4449700 |  |
IC50 | = | 0.26 | nM | 356.43 | COc1ccc(-c2ccc(Cn3cc(-c4ccc(C)cc4)nn3)cc2)cn1 | Homo sapiens | CHEMBL4330409 | single protein format |
| CHEMBL4447552 |  |
IC50 | = | 0.28 | nM | 346.82 | Clc1cccc(-c2cn(Cc3ccc(-c4cccnc4)cc3)nn2)c1 | Homo sapiens | CHEMBL4330409 | single protein format |
| CHEMBL3950106 |  |
IC50 | = | 0.3 | nM | 547.71 | Cc1ccc(NC(=O)c2cc(N3CCN(C)CC3)cc(C(C)(C)C)c2)cc1-n1ccn2nc(-c3cccnc3)cc12 | Homo sapiens | CHEMBL3888827 | single protein format |
| CHEMBL3976004 |  |
IC50 | = | 0.3 | nM | 529.65 | Cc1ccc(NC(=O)c2cc(-n3ccnc3C)cc(C(C)(C)C)c2)cc1-n1ccn2nc(-c3cccnc3)cc12 | Homo sapiens | CHEMBL3888827 | single protein format |
| CHEMBL3967492 |  |
IC50 | = | 0.3 | nM | 507.64 | Cc1ccc(NC(=O)c2cc(C(C)(C)C)cc(C(C)(C)O)c2)cc1-n1ccn2nc(-c3cccnc3)cc12 | Homo sapiens | CHEMBL3888827 | single protein format |
| CHEMBL3937186 |  |
IC50 | = | 0.3 | nM | 488.6 | Cc1cc(C)c(-n2ccn3nc(-c4cccnc4)cc23)cc1NC(=O)c1cc(C#N)cc(C(C)(C)C)c1 | Homo sapiens | CHEMBL3888827 | single protein format |
| CHEMBL4528844 |  |
IC50 | = | 0.3 | nM | 410.4 | COc1ccc(-c2ccc(Cn3cc(-c4ccc(C(F)(F)F)cc4)nn3)cc2)cn1 | Homo sapiens | CHEMBL4330409 | single protein format |
| CHEMBL4452256 |  |
IC50 | = | 0.36 | nM | 376.85 | COc1ccc(-c2ccc(Cn3cc(-c4cccc(Cl)c4)nn3)cc2)cn1 | Homo sapiens | CHEMBL4330409 | single protein format |
| CHEMBL3978122 |  |
IC50 | = | 0.4 | nM | 544.54 | Cc1ccc(NC(=O)c2cc(-n3ccnc3C)cc(C(F)(F)F)c2)cc1-n1cc(C)n2nc(-c3cn[nH]c3)cc12 | Homo sapiens | CHEMBL3888827 | single protein format |
| CHEMBL3922694 |  |
IC50 | = | 0.4 | nM | 492.56 | Cc1cc(F)c(NC(=O)c2cc(C#N)cc(C(C)(C)C)c2)cc1-n1ccn2nc(-c3cccnc3)cc12 | Homo sapiens | CHEMBL3888827 | single protein format |
| CHEMBL3907057 |  |
IC50 | = | 0.45 | nM | 558.54 | Cc1cc(C)c(-n2ccn3nc(-c4cccnc4)cc23)cc1NC(=O)c1cc(C#N)cc(S(F)(F)(F)(F)F)c1 | Homo sapiens | CHEMBL4881418 | single protein format |
| CHEMBL4570075 |  |
IC50 | = | 0.45 | nM | 326.4 | Cc1cccc(-c2cn(Cc3ccc(-c4cccnc4)cc3)nn2)c1 | Homo sapiens | CHEMBL4330409 | single protein format |
| CHEMBL3967691 |  |
IC50 | = | 0.5 | nM | 477.57 | Cc1cc(C)c(-n2ccn3nc(-c4cccnc4)cc23)cc1NC(=O)c1cccc(C2(C)COC2)c1 | Homo sapiens | CHEMBL3888827 | single protein format |
| CHEMBL3896522 |  |
IC50 | = | 0.5 | nM | 517.56 | Cc1cc(C)c(-n2ccn3nc(-c4cccnc4)cc23)cc1NC(=O)c1cccc(C(C)(C)C(F)(F)F)c1 | Homo sapiens | CHEMBL3888827 | single protein format |
| CHEMBL3959425 |  |
IC50 | = | 0.5 | nM | 541.54 | Cc1ccc(NC(=O)c2cc(-n3ccnc3C)cc(C(F)(F)F)c2)cc1-n1ccn2nc(-c3cccnc3)cc12 | Homo sapiens | CHEMBL3888827 | single protein format |
| CHEMBL3950414 |  |
IC50 | = | 0.5 | nM | 489.58 | Cc1cc(C)c(-n2ccn3nc(-c4cccnc4)cc23)cc1NC(=O)c1cc(C#N)nc(C(C)(C)C)c1 | Homo sapiens | CHEMBL3888827 | single protein format |
| CHEMBL4066813 |  |
IC50 | = | 0.6 | nM | 534.36 | Nc1ncc2ccc(-c3ccc(NC(=S)Nc4cc(Br)ccc4OC(F)(F)F)cc3)cc2n1 | Homo sapiens | CHEMBL3993540 | single protein format |
| CHEMBL3944654 |  |
IC50 | = | 0.6 | nM | 542.48 | Cc1cc(C)c(-n2ccn3nc(-c4cccnc4)cc23)cc1NC(=O)c1cc(Br)cc(C(C)(C)C)c1 | Homo sapiens | CHEMBL3888827 | single protein format |