Q02750 | MP2K1_HUMAN | Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 68~361 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3818606 |  |
IC50 | = | 0.00715 | nM | 451.19 | NCCONC(=O)c1ccc(F)c(F)c1Nc1ccc(I)cc1F | Homo sapiens | CHEMBL3820565 | single protein format |
| CHEMBL450775 |  |
IC50 | = | 0.6 | nM | 482.2 | O=C(NOCC(O)CO)c1ccc(F)c(F)c1Nc1ccc(I)cc1F | Homo sapiens | CHEMBL2149502 | single protein format |
| CHEMBL2146883 |  |
IC50 | = | 0.9 | nM | 531.32 | O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)([C@@H]2CCCCN2)C1 | Homo sapiens | CHEMBL2149502 | single protein format |
| CHEMBL106489 |  |
IC50 | = | 1.0 | nM | 579.13 | COc1cc2c(Nc3ccc(Sc4ncc(C)n4C)c(Cl)c3)c(C#N)cnc2cc1OCCCN1CCOCC1 | Homo sapiens | CHEMBL734032 | single protein format |
| CHEMBL435734 |  |
IC50 | = | 1.0 | nM | 372.42 | COc1cc(C[C@H]2C(=O)OC[C@@H]2Cc2ccc(OC)c(OC)c2)ccc1O | Homo sapiens | CHEMBL921092 | single protein format |
| CHEMBL288441 |  |
IC50 | = | 1.0 | nM | 530.46 | COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl | Homo sapiens | CHEMBL3813585 | single protein format |
| CHEMBL29714 |  |
IC50 | = | 1.1 | nM | 526.66 | COc1cc2c(Nc3ccc(Sc4ccccc4)cc3)c(C#N)cnc2cc1OCCCN1CCOCC1 | Homo sapiens | CHEMBL672143 | single protein format |
| CHEMBL3261161 |  |
IC50 | = | 1.63 | nM | 456.21 | O=c1c2c(Nc3ccc(I)cc3F)cncc2cnn1C[C@H](O)CO | Homo sapiens | CHEMBL3266112 | single protein format |
| CHEMBL2146893 |  |
IC50 | = | 1.8 | nM | 519.31 | CC(C)NCC1(O)CN(C(=O)c2ccc(F)c(F)c2Nc2ccc(I)cc2F)C1 | Homo sapiens | CHEMBL2149502 | single protein format |
| CHEMBL4588064 |  |
IC50 | = | 2.0 | nM | 466.2 | O=C(NOCCCO)c1ccc(F)c(F)c1Nc1ccc(I)cc1F | Homo sapiens | CHEMBL4320879 | single protein format |
| CHEMBL102374 |  |
IC50 | = | 2.0 | nM | 593.15 | COc1cc2c(Nc3ccc(Sc4nc(C)c(C)n4C)c(Cl)c3)c(C#N)cnc2cc1OCCCN1CCOCC1 | Homo sapiens | CHEMBL734032 | single protein format |
| CHEMBL105642 |  |
IC50 | = | 2.0 | nM | 597.17 | COc1cc2c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c(C#N)cnc2cc1OCCCN1CC[S+]([O-])CC1 | Homo sapiens | CHEMBL734032 | single protein format |
| CHEMBL318804 |  |
IC50 | = | 2.0 | nM | 565.1 | COc1cc2c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c(C#N)cnc2cc1OCCCN1CCOCC1 | Homo sapiens | CHEMBL734032 | single protein format |
| CHEMBL1668411 |  |
IC50 | = | 2.0 | nM | 362.38 | COc1cc(O)c2c(c1)/C=C/C[C@@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O | Homo sapiens | CHEMBL1670834 | cell-based format |
| CHEMBL244488 |  |
IC50 | = | 2.0 | nM | 452.17 | O=C(NOCCO)c1ccc(F)c(F)c1Nc1ccc(I)cc1F | Homo sapiens | CHEMBL2341896 | single protein format |
| CHEMBL105442 |  |
IC50 | = | 2.0 | nM | 478.66 | O=C(NOCC1CC1)c1ccc(F)c(F)c1Nc1ccc(I)cc1Cl | Homo sapiens | CHEMBL734032 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 2.5 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL731425 | single protein format |
| CHEMBL30728 |  |
IC50 | = | 2.7 | nM | 508.62 | COc1cc2c(Nc3ccc(Cc4ccccc4)cc3)c(C#N)cnc2cc1OCCCN1CCOCC1 | Homo sapiens | CHEMBL672143 | single protein format |
| CHEMBL1097700 |  |
IC50 | = | 2.8 | nM | 375.42 | CNc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O | Homo sapiens | CHEMBL3880853 | single protein format |
| CHEMBL485615 |  |
IC50 | = | 3.0 | nM | 547.13 | CCN(CC)CC/C=C/c1cc2ncc(C#N)c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c2cc1OC | Homo sapiens | CHEMBL995059 | single protein format |