Q02224 | CENPE_HUMAN | Centromere-associated protein E (CENPE)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00225 | Kinesin - Kinesin motor domain | 12~327 |
3D structures mapped by conservation among orthologs
[ Domain: "EB1 dimerisation domain-like" // EB1_1 ]
[ Domain: "EB1 dimerisation domain-like" // EB1_1 ]
[ Domain: "P-loop containing nucleoside triphosphate hydrolases" // Kinesin ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4579162 |  |
IC50 | = | 14.0 | nM | 573.52 | COc1cccc2nc(C(=O)N(CCN(C)C)C3CSc4c3ccc(Cl)c4Cl)c(-c3ccc(F)c(C)c3)n12 | Homo sapiens | CHEMBL4427798 | single protein format |
| CHEMBL4466617 |  |
IC50 | = | 19.0 | nM | 555.48 | COc1cccc2nc(C(=O)N(CCN(C)C)C3CCc4c3ccc(Cl)c4Cl)c(-c3ccc(F)c(C)c3)n12 | Homo sapiens | CHEMBL4427798 | single protein format |
| CHEMBL4483703 |  |
IC50 | = | 24.0 | nM | 556.47 | COc1cccc2nc(C(=O)N(CCN(C)C)C3CNc4c3ccc(Cl)c4Cl)c(-c3ccc(F)c(C)c3)n12 | Homo sapiens | CHEMBL4427798 | single protein format |
| CHEMBL2413142 |  |
IC50 | = | 32.0 | nM | 569.33 | CN(C)CCN(Cc1ccc(Cl)c(Cl)c1)C(=O)c1cc2scc(Br)c2n1-c1ccc(F)cc1 | Homo sapiens | CHEMBL2416484 | single protein format |
| CHEMBL2413143 |  |
IC50 | = | 35.0 | nM | 524.88 | CN(C)CCN(Cc1ccc(Cl)c(Cl)c1)C(=O)c1cc2scc(Cl)c2n1-c1ccc(F)cc1 | Homo sapiens | CHEMBL2416484 | single protein format |
| CHEMBL2413146 |  |
IC50 | = | 50.0 | nM | 564.29 | CN(C)CCN(Cc1ccc(Cl)c(Cl)c1)C(=O)c1nc2cccc(Br)n2c1-c1ccc(F)cc1 | Homo sapiens | CHEMBL2416484 | single protein format |
| CHEMBL2413135 |  |
IC50 | = | 72.0 | nM | 532.47 | CN(C)CCn1c(C(=O)N(C)Cc2ccc(Cl)c(Cl)c2)c(-c2ccc(F)cc2)c2cscc2c1=O | Homo sapiens | CHEMBL2416484 | single protein format |
| CHEMBL2413137 |  |
IC50 | = | 100.0 | nM | 532.47 | CN(C)CCN(Cc1ccc(Cl)c(Cl)c1)C(=O)c1c(-c2ccc(F)cc2)c2cscc2c(=O)n1C | Homo sapiens | CHEMBL2416484 | single protein format |
| CHEMBL2413144 |  |
IC50 | = | 140.0 | nM | 558.43 | CN(C)CCN(Cc1ccc(Cl)c(Cl)c1)C(=O)c1cc2scc(C(F)(F)F)c2n1-c1ccc(F)cc1 | Homo sapiens | CHEMBL2416484 | single protein format |
| CHEMBL2413136 |  |
IC50 | = | 300.0 | nM | 546.5 | CN(C)CCCn1c(C(=O)N(C)Cc2ccc(Cl)c(Cl)c2)c(-c2ccc(F)cc2)c2cscc2c1=O | Homo sapiens | CHEMBL2416484 | single protein format |
| CHEMBL2413141 |  |
IC50 | = | 370.0 | nM | 504.46 | Cc1csc2cc(C(=O)N(CCN(C)C)Cc3ccc(Cl)c(Cl)c3)n(-c3ccc(F)cc3)c12 | Homo sapiens | CHEMBL2416484 | single protein format |
| CHEMBL2413145 |  |
IC50 | = | 540.0 | nM | 515.44 | CN(C)CCN(Cc1ccc(Cl)c(Cl)c1)C(=O)c1cc2scc(C#N)c2n1-c1ccc(F)cc1 | Homo sapiens | CHEMBL2416484 | single protein format |
| CHEMBL4303470 |  |
Ki | = | 3.2 | nM | 592.14 | CC(C)Oc1ccc(C(=O)N[C@H](CNC(=O)CN(C)C)Cc2ccc(-c3cn4cccc([C@H](C)O)c4n3)cc2)cc1Cl | Homo sapiens | CHEMBL5446134 | single protein format |