Q02156 | KPCE_HUMAN | Protein kinase C epsilon type (PRKCE)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 409~667 | |
| PF00130 | C1_1 - Phorbol esters/diacylglycerol binding domain (C1 domain) | 170~221 | |
| PF00130 | C1_1 - Phorbol esters/diacylglycerol binding domain (C1 domain) | 243~294 | |
| PF00168 | C2 - C2 domain | 7~116 | |
| PF00433 | Pkinase_C - Protein kinase C terminal domain | 689~730 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2151411 |  |
IC50 | = | 0.7 | nM | 452.52 | Cc1cccc2c(C3=C(c4nc(N5CCN(C)CC5)nc5ccccc45)C(=O)NC3=O)c[nH]c12 | Homo sapiens | CHEMBL2156014 | single protein format |
| CHEMBL1996510 |  |
IC50 | = | 0.9 | nM | 424.46 | O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1c1nc(N2CCNCC2)nc2ccccc12 | Homo sapiens | CHEMBL2156014 | single protein format |
| CHEMBL1080994 |  |
IC50 | = | 1.6 | nM | 512.64 | Cc1c(Nc2c(C#N)cncc2/C=C/c2cccc(S(=O)(=O)N3CCN(C)CC3)c2)ccc2[nH]ccc12 | Homo sapiens | CHEMBL1114004 | single protein format |
| CHEMBL1084411 |  |
IC50 | = | 2.0 | nM | 463.59 | Cc1c(Nc2c(C#N)cncc2/C=C/c2cccc(CN3CCN(C)CC3)n2)ccc2[nH]ccc12 | Homo sapiens | CHEMBL1105155 | single protein format |
| CHEMBL2153750 |  |
IC50 | = | 2.0 | nM | 456.48 | CN1CCN(c2nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3cc(F)ccc3n2)CC1 | Homo sapiens | CHEMBL2156014 | single protein format |
| CHEMBL571581 |  |
IC50 | = | 2.5 | nM | 476.58 | Cc1c(Nc2c(C#N)cncc2-c2cc3cc(CN4CCN(C)CC4)ccc3o2)ccc2[nH]ccc12 | Homo sapiens | CHEMBL1047194 | single protein format |
| CHEMBL603418 |  |
IC50 | = | 2.5 | nM | 386.5 | Cc1c(Nc2c(C#N)cncc2/C=C/CCN2CCNCC2)ccc2[nH]ccc12 | Homo sapiens | CHEMBL1070548 | single protein format |
| CHEMBL2151415 |  |
IC50 | = | 3.8 | nM | 438.49 | Cn1cc(C2=C(c3nc(N4CCNCC4)nc4ccccc34)C(=O)NC2=O)c2ccccc21 | Homo sapiens | CHEMBL2156014 | single protein format |
| CHEMBL2153751 |  |
IC50 | = | 3.9 | nM | 472.94 | CN1CCN(c2nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3cc(Cl)ccc3n2)CC1 | Homo sapiens | CHEMBL2156014 | single protein format |
| CHEMBL4085837 |  |
IC50 | = | 4.3 | nM | 429.91 | CN(C)Cc1ccc2c(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c(Cl)ccc2c1 | Homo sapiens | CHEMBL4004543 | single protein format |
| CHEMBL2153748 |  |
IC50 | = | 4.3 | nM | 437.5 | CN1CCN(c2cc3ccccc3c(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)n2)CC1 | Homo sapiens | CHEMBL2156014 | single protein format |
| CHEMBL2147537 |  |
IC50 | = | 5.0 | nM | 279.35 | C[C@H](N)CNc1nc(-c2ccncc2)cc2cnccc12 | Homo sapiens | CHEMBL2150523 | single protein format |
| CHEMBL1214929 |  |
IC50 | = | 5.0 | nM | 265.32 | NCCNc1nc(-c2ccncc2)cc2cnccc12 | Homo sapiens | CHEMBL2150523 | single protein format |
| CHEMBL565632 |  |
IC50 | = | 5.5 | nM | 425.49 | CN(C)CCOc1cc(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)c2ccccc2c1 | Homo sapiens | CHEMBL1040089 | single protein format |
| CHEMBL7463 |  |
IC50 | = | 6.0 | nM | 412.49 | CN(C)CCCn1cc(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)c2ccccc21 | Homo sapiens | CHEMBL966809 | single protein format |
| CHEMBL2153749 |  |
IC50 | = | 6.2 | nM | 452.52 | Cc1cccc2nc(N3CCN(C)CC3)nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c12 | Homo sapiens | CHEMBL2156014 | single protein format |
| CHEMBL565612 |  |
IC50 | = | 6.2 | nM | 438.49 | CN1CCN(c2nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3ccccc3n2)CC1 | Homo sapiens | CHEMBL1040089 | single protein format |
| CHEMBL593883 |  |
IC50 | = | 6.5 | nM | 400.53 | Cc1c(Nc2c(C#N)cncc2/C=C/CCN2CCC(N)CC2)ccc2[nH]ccc12 | Homo sapiens | CHEMBL1070548 | single protein format |
| CHEMBL2147542 |  |
IC50 | = | 7.0 | nM | 305.39 | c1cc(-c2cc3cnccc3c(N3CCCNCC3)n2)ccn1 | Homo sapiens | CHEMBL2150523 | single protein format |
| CHEMBL567124 |  |
IC50 | = | 7.0 | nM | 492.63 | Cc1c(Nc2c(C#N)cncc2/C=C/c2cccc(OCCN3CCN(C)CC3)c2)ccc2[nH]ccc12 | Homo sapiens | CHEMBL1039938 | single protein format |