ProtHub

Q02083 | NAAA_HUMAN | N-acylethanolamine-hydrolyzing acid amidase (NAAA)

Pfam Domain Table

Accession	Domain	Range	Color
PF02275	CBAH - Linear amide C-N hydrolases, choloylglycine hydrolase family	126~255
PF15508	NAAA-beta - beta subunit of N-acylethanolamine-hydrolyzing acid amidase	32~91

3D structures mapped by conservation among orthologs

[ Domain: "Penicillin acylase, catalytic domain" // UNK_F_TYPE ]

6DXW
6DXX

PyMOL session

[ Alpha Fold Model ] (go)

Known binders annotated in ChEMBL

IC50 CSV

Only the first 20 rows are shown.

molecule_chembl_id	assay_type	relation	value	unit	mol_wt	smiles	organism	assay_chembl_id	bao_label
CHEMBL4633233	IC50	=	0.35	nM	370.4	COc1ccc(-c2ccc(COC3(C4CC4)CN(C#N)C3)c(F)c2)cc1F	Homo sapiens	CHEMBL4610452	single protein format
CHEMBL4640552	IC50	=	0.46	nM	278.36	Cc1ccc(-c2ccc(COC3CN(C#N)C3)cc2)cc1	Homo sapiens	CHEMBL4610452	single protein format
CHEMBL4642793	IC50	=	0.47	nM	312.34	COc1cccc(-c2ccc(COC3CN(C#N)C3)c(F)c2)c1	Homo sapiens	CHEMBL4610452	single protein format
CHEMBL4635208	IC50	=	0.68	nM	282.32	N#CN1CC(OCc2ccc(-c3ccc(F)cc3)cc2)C1	Homo sapiens	CHEMBL4610452	single protein format
CHEMBL4640519	IC50	=	0.85	nM	362.35	COc1cccc(-c2ccc(COC3CN(C#N)C3)c(C(F)(F)F)c2)c1	Homo sapiens	CHEMBL4610452	single protein format
CHEMBL4644090	IC50	=	0.88	nM	324.38	COc1cccc(-c2ccc(COC3CN(C#N)C3)cc2)c1OC	Homo sapiens	CHEMBL4610452	single protein format
CHEMBL4633213	IC50	=	0.89	nM	294.35	COc1cccc(-c2ccc(COC3CN(C#N)C3)cc2)c1	Homo sapiens	CHEMBL4610452	single protein format
CHEMBL4649536	IC50	=	0.94	nM	294.35	COc1ccc(-c2ccc(COC3CN(C#N)C3)cc2)cc1	Homo sapiens	CHEMBL4610452	single protein format
CHEMBL4637701	IC50	=	1.03	nM	359.22	N#CN1CC(OCc2ccc(Oc3ccccc3)cc2Br)C1	Homo sapiens	CHEMBL4610452	single protein format
CHEMBL4646880	IC50	=	1.1	nM	280.33	N#CN1CC(OCc2ccc(Oc3ccccc3)cc2)C1	Homo sapiens	CHEMBL4610452	single protein format
CHEMBL4632623	IC50	=	1.4	nM	370.45	N#CN1CC(OCc2ccc(-c3cccc(OCc4ccccc4)c3)cc2)C1	Homo sapiens	CHEMBL4610452	single protein format
CHEMBL4635238	IC50	=	1.58	nM	321.38	COc1cccc(-c2ccc(C(=O)NC3(C)CN(C#N)C3)cc2)c1	Homo sapiens	CHEMBL4610452	single protein format
CHEMBL4645560	IC50	=	1.6	nM	323.37	COc1ccc(-c2ccc3c(c2)CN(C2CN(C#N)C2)C3)cc1F	Homo sapiens	CHEMBL4610452	single protein format
CHEMBL4646586	IC50	=	1.6	nM	332.32	N#CN1CC(OCc2ccc(-c3ccc(C(F)(F)F)cc3)cc2)C1	Homo sapiens	CHEMBL4610452	single protein format
CHEMBL4641417	IC50	=	1.8	nM	308.38	COc1cccc(-c2ccc(COC3(C)CN(C#N)C3)cc2)c1	Homo sapiens	CHEMBL4610452	single protein format
CHEMBL4872294	IC50	=	2.3	nM	374.49	COc1ccc(-c2ccc(S(=O)(=O)N[C@H]3C[C@@H](N=C=S)C3)cc2)cc1	Homo sapiens	CHEMBL4835807	single protein format
CHEMBL4643427	IC50	=	2.5	nM	381.44	N#Cc1ccc(-c2cc(Oc3ccccc3)ccc2COC2CN(C#N)C2)cc1	Homo sapiens	CHEMBL4610452	single protein format
CHEMBL4636322	IC50	=	2.8	nM	324.38	COc1cccc(-c2ccc(COC3CN(C#N)C3)c(OC)c2)c1	Homo sapiens	CHEMBL4610452	single protein format
CHEMBL4642907	IC50	=	2.8	nM	264.33	N#CN1CC(OCc2ccc(-c3ccccc3)cc2)C1	Homo sapiens	CHEMBL4610452	single protein format
CHEMBL4637755	IC50	=	2.8	nM	369.45	COc1cccc(-c2ccc(S(=O)(=O)N3CCC34CN(C#N)C4)cc2)c1	Homo sapiens	CHEMBL4610452	single protein format