Q01718 | ACTHR_HUMAN | Adrenocorticotropic hormone receptor (MC2R)
Helixβ‑strandTurn secondary structure
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 | 41–276 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5406402 |  |
Ki | = | 1.3 | nM | 587.69 | CCOc1ccccc1-c1ccc(N2CCN(C(=O)C3(C(F)(F)F)CCC3)C[C@H]2CC)c(C(=O)N[C@@H]2CCN(C)C2)n1 | Homo sapiens | CHEMBL5346798 | single protein format |
| CHEMBL5422885 |  |
Ki | = | 3.7 | nM | 588.68 | CCOc1ncccc1-c1ccc(N2CCN(C(=O)C3(C(F)(F)F)CCC3)C[C@H]2CC)c(C(=O)N[C@@H]2CCN(C)C2)n1 | Homo sapiens | CHEMBL5346798 | single protein format |
| CHEMBL5405192 |  |
Ki | = | 4.8 | nM | 569.53 | CCOc1ccccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3Cl)C[C@H]2CC)c(C(=O)NCCN)c1 | Homo sapiens | CHEMBL5346798 | single protein format |
| CHEMBL5435301 |  |
Ki | = | 21.0 | nM | 593.48 | CC[C@@H]1CN(C(=O)c2ccc(C(F)(F)F)cc2Cl)CCN1c1ccc(-c2ccccc2Cl)cc1C(=O)NCCN | Homo sapiens | CHEMBL5346798 | single protein format |
| CHEMBL5396826 |  |
Ki | = | 25.0 | nM | 584.04 | CC[C@@H]1CN(C(=O)c2ccc(C(F)(F)F)cc2Cl)CCN1c1ccc(-c2ccccc2C#N)cc1C(=O)NCCN | Homo sapiens | CHEMBL5346798 | single protein format |
| CHEMBL5438731 |  |
Ki | = | 47.0 | nM | 577.02 | CC[C@@H]1CN(C(=O)c2ccc(C(F)(F)F)cc2Cl)CCN1c1ccc(-c2ccccc2F)cc1C(=O)NCCN | Homo sapiens | CHEMBL5346798 | single protein format |