Q01433 | AMPD2_HUMAN | AMP deaminase 2 (AMPD2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF19326 | AMP_deaminase - AMP deaminase | 163~806 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5269095 |  |
IC50 | = | 30.0 | nM | 313.38 | CC1(C)CN(C(N)=O)c2cccc(F)c2N1Cc1ccccc1 | Homo sapiens | CHEMBL5240593 | single protein format |
| CHEMBL5271711 |  |
IC50 | = | 60.0 | nM | 331.37 | CC1(C)CN(C(N)=O)c2ccc(F)c(F)c2N1Cc1ccccc1 | Homo sapiens | CHEMBL5240593 | single protein format |
| CHEMBL5272816 |  |
IC50 | = | 100.0 | nM | 467.52 | CC1(C)CN(C(N)=O)c2ccc(F)c(F)c2N1Cc1ccc(COc2ccc(CO)cc2)cc1 | Homo sapiens | CHEMBL5240593 | single protein format |
| CHEMBL5270167 |  |
IC50 | = | 110.0 | nM | 401.51 | CC1(C)CN(C(N)=O)c2ccccc2N1Cc1ccc(COc2ccccc2)cc1 | Homo sapiens | CHEMBL5240593 | single protein format |
| CHEMBL5287644 |  |
IC50 | = | 130.0 | nM | 437.49 | CC1(C)CN(C(N)=O)c2ccc(F)c(F)c2N1Cc1ccc(COc2ccccc2)cc1 | Homo sapiens | CHEMBL5240593 | single protein format |
| CHEMBL5287535 |  |
IC50 | = | 140.0 | nM | 379.38 | CC1(C)CN(C(N)=O)c2ccccc2N1Cc1cccc(OC(F)(F)F)c1 | Homo sapiens | CHEMBL5240593 | single protein format |
| CHEMBL5276735 |  |
IC50 | = | 170.0 | nM | 309.41 | Cc1ccc(CN2c3ccccc3N(C(N)=O)CC2(C)C)cc1 | Homo sapiens | CHEMBL5240593 | single protein format |
| CHEMBL5281489 |  |
IC50 | = | 170.0 | nM | 494.54 | CC(=O)Nc1ccc(OCc2ccc(CN3c4c(ccc(F)c4F)N(C(N)=O)CC3(C)C)cc2)cc1 | Homo sapiens | CHEMBL5240593 | single protein format |
| CHEMBL5284620 |  |
IC50 | = | 180.0 | nM | 329.83 | CC1(C)CN(C(N)=O)c2cccc(Cl)c2N1Cc1ccccc1 | Homo sapiens | CHEMBL5240593 | single protein format |
| CHEMBL5289502 |  |
IC50 | = | 190.0 | nM | 329.83 | CC1(C)CN(C(N)=O)c2ccccc2N1Cc1ccc(Cl)cc1 | Homo sapiens | CHEMBL5240593 | single protein format |
| CHEMBL5281034 |  |
IC50 | = | 200.0 | nM | 480.52 | CC1(C)CN(C(N)=O)c2ccc(F)c(F)c2N1Cc1ccc(COc2ccc(C(N)=O)cc2)cc1 | Homo sapiens | CHEMBL5240593 | single protein format |
| CHEMBL5271550 |  |
IC50 | = | 200.0 | nM | 329.83 | CC1(C)CN(C(N)=O)c2ccccc2N1Cc1cccc(Cl)c1 | Homo sapiens | CHEMBL5240593 | single protein format |
| CHEMBL5266374 |  |
IC50 | = | 240.0 | nM | 313.38 | CC1(C)CN(C(N)=O)c2cc(F)ccc2N1Cc1ccccc1 | Homo sapiens | CHEMBL5240593 | single protein format |
| CHEMBL5283087 |  |
IC50 | = | 260.0 | nM | 331.37 | CC1(C)CN(C(N)=O)c2cc(F)cc(F)c2N1Cc1ccccc1 | Homo sapiens | CHEMBL5240593 | single protein format |
| CHEMBL5284666 |  |
IC50 | = | 270.0 | nM | 379.38 | CC1(C)CN(C(N)=O)c2ccccc2N1Cc1ccc(OC(F)(F)F)cc1 | Homo sapiens | CHEMBL5240593 | single protein format |
| CHEMBL5280447 |  |
IC50 | = | 270.0 | nM | 295.39 | CC1(C)CN(C(N)=O)c2ccccc2N1Cc1ccccc1 | Homo sapiens | CHEMBL5240593 | single protein format |
| CHEMBL5277889 |  |
IC50 | = | 300.0 | nM | 309.41 | Cc1cccc(CN2c3ccccc3N(C(N)=O)CC2(C)C)c1 | Homo sapiens | CHEMBL5240593 | single protein format |
| CHEMBL5280490 |  |
IC50 | = | 410.0 | nM | 399.54 | CC1(C)CN(C(N)=O)c2ccccc2N1Cc1ccc(CCc2ccccc2)cc1 | Homo sapiens | CHEMBL5240593 | single protein format |
| CHEMBL5282638 |  |
IC50 | = | 500.0 | nM | 399.54 | CC1(C)CN(C(N)=O)c2ccccc2N1Cc1cccc(CCc2ccccc2)c1 | Homo sapiens | CHEMBL5240593 | single protein format |
| CHEMBL5284646 |  |
IC50 | = | 500.0 | nM | 313.38 | CC1(C)CN(C(N)=O)c2c(F)cccc2N1Cc1ccccc1 | Homo sapiens | CHEMBL5240593 | single protein format |