Q01432 | AMPD3_HUMAN | AMP deaminase 3 (AMPD3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF19326 | AMP_deaminase - AMP deaminase | 128~759 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2042530 |  |
IC50 | = | 900.0 | nM | 322.37 | O=C(O)c1cc2c(c(CCc3cnc4cncnn34)c1)CCCC2 | Homo sapiens | CHEMBL2044566 | cell-based format |
| CHEMBL346040 |  |
Ki | = | 2.0 | nM | 433.31 | O=C(O)c1cc(CCn2cnc3c2NC=NCC3O)c2c(c1Br)CCCC2 | Homo sapiens | CHEMBL645676 | single protein format |
| CHEMBL157468 |  |
Ki | = | 9.0 | nM | 460.53 | O=C(O)c1cc(CCn2cnc3c2NC=NCC3O)c2c(c1OCc1ccccc1)CCCC2 | Homo sapiens | CHEMBL645676 | single protein format |
| CHEMBL157949 |  |
Ki | = | 15.0 | nM | 354.41 | O=C(O)c1cc2c(c(CCn3cnc4c3NC=NCC4O)c1)CCCC2 | Homo sapiens | CHEMBL645676 | single protein format |
| CHEMBL346360 |  |
Ki | = | 20.0 | nM | 350.38 | O=C(O)c1cc(CCn2cnc3c2NC=NCC3O)c2ccccc2c1 | Homo sapiens | CHEMBL645676 | single protein format |
| CHEMBL37273 |  |
Ki | = | 29.0 | nM | 468.43 | O=C(O)C(CCCCn1cnc2c1NC=NCC2O)(Cc1cccc(C(F)(F)F)c1)C(=O)O | Homo sapiens | CHEMBL644199 | single protein format |
| CHEMBL160174 |  |
Ki | = | 30.0 | nM | 384.44 | COc1c(C(=O)O)cc(CCn2cnc3c2NC=NCC3O)c2c1CCCC2 | Homo sapiens | CHEMBL645676 | single protein format |
| CHEMBL289398 |  |
Ki | = | 40.0 | nM | 468.43 | O=C(O)C(CCCCn1cnc2c1NC=NCC2O)(Cc1ccc(C(F)(F)F)cc1)C(=O)O | Homo sapiens | CHEMBL644199 | single protein format |
| CHEMBL157743 |  |
Ki | = | 40.0 | nM | 384.44 | COc1c(C(=O)O)cc2c(c1CCn1cnc3c1NC=NCC3O)CCCC2 | Homo sapiens | CHEMBL645676 | single protein format |
| CHEMBL288742 |  |
Ki | = | 41.0 | nM | 468.43 | O=C(O)C(CCCCn1cnc2c1NC=NCC2O)(Cc1ccccc1C(F)(F)F)C(=O)O | Homo sapiens | CHEMBL644199 | single protein format |
| CHEMBL280097 |  |
Ki | = | 50.0 | nM | 423.3 | O=C(O)c1c(Cl)c2c(c(CCn3cnc4c3NC=NCC4O)c1Cl)CCCC2 | Homo sapiens | CHEMBL645676 | single protein format |
| CHEMBL158023 |  |
Ki | = | 90.0 | nM | 412.49 | CC(C)Oc1c(C(=O)O)cc(CCn2cnc3c2NC=NCC3O)c2c1CCCC2 | Homo sapiens | CHEMBL645676 | single protein format |
| CHEMBL39940 |  |
Ki | = | 170.0 | nM | 400.44 | O=C(O)C(CCCCn1cnc2c1NC=NCC2O)(Cc1ccccc1)C(=O)O | Homo sapiens | CHEMBL644199 | single protein format |
| CHEMBL157426 |  |
Ki | = | 220.0 | nM | 418.38 | O=C(O)c1cc(CCn2cnc3c2NC=NCC3O)c2cccc(C(F)(F)F)c2c1 | Homo sapiens | CHEMBL645676 | single protein format |
| CHEMBL158136 |  |
Ki | = | 300.0 | nM | 488.59 | CCOC(=O)c1cc(CCn2cnc3c2NC=NCC3O)c2c(c1OCc1ccccc1)CCCC2 | Homo sapiens | CHEMBL645676 | single protein format |
| CHEMBL350676 |  |
Ki | = | 300.0 | nM | 513.43 | O=C(OCc1ccccc1)c1c(Cl)c2c(c(CCn3cnc4c3NC=NCC4O)c1Cl)CCCC2 | Homo sapiens | CHEMBL645676 | single protein format |
| CHEMBL39406 |  |
Ki | = | 360.0 | nM | 400.44 | O=C(O)C(CCCCn1cnc2c1NC=NCC2O)C(=O)OCc1ccccc1 | Homo sapiens | CHEMBL644199 | single protein format |
| CHEMBL286566 |  |
Ki | = | 360.0 | nM | 524.54 | CCOC(=O)C(CCCCn1cnc2c1NC=NCC2O)(Cc1ccccc1C(F)(F)F)C(=O)OCC | Homo sapiens | CHEMBL644199 | single protein format |
| CHEMBL35929 |  |
Ki | = | 410.0 | nM | 356.43 | O=C(O)C(CCCCn1cnc2c1NC=NCC2O)Cc1ccccc1 | Homo sapiens | CHEMBL645676 | single protein format |
| CHEMBL35524 |  |
Ki | = | 500.0 | nM | 300.32 | O=C(O)c1cccc(CCn2cnc3c2NC=NCC3O)c1 | Homo sapiens | CHEMBL645676 | single protein format |