Q01118 | SCN7A_HUMAN | Sodium channel protein type 7 subunit alpha (SCN7A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00520 | Ion_trans - Ion transport protein | 117~403 | |
| PF00520 | Ion_trans - Ion transport protein | 505~731 | |
| PF00520 | Ion_trans - Ion transport protein | 934~1199 | |
| PF00520 | Ion_trans - Ion transport protein | 1251~1501 | |
| PF06512 | Na_trans_assoc - Sodium ion transport-associated | 743~927 | |
| PF24609 | IQ_SCN5A_C - SCN5A-like, C-terminal IQ motif | 1618~1650 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3657855 |  |
IC50 | = | 0.4 | nM | 462.59 | O=C(NS(=O)(=O)N1CCC1)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F | Homo sapiens | CHEMBL4321987 | cell-based format |
| CHEMBL3662190 |  |
IC50 | = | 0.6 | nM | 435.56 | CC1(COc2cc(F)c(C(=O)NS(=O)(=O)C3CC3)cc2C2CC2)CCC2(CC1)CC2 | Homo sapiens | CHEMBL4321987 | cell-based format |
| CHEMBL5082131 |  |
IC50 | = | 0.8 | nM | 557.52 | CC(C)(c1cc(Cl)cc(Cl)c1)N1CCC(COc2cc(F)c(C(=O)NS(C)(=O)=O)cc2C2CC2)CC1 | Homo sapiens | CHEMBL5055691 | cell-based format |
| CHEMBL3657932 |  |
IC50 | = | 1.1 | nM | 447.57 | O=C(NS(=O)(=O)C1CC1)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F | Homo sapiens | CHEMBL5055691 | cell-based format |
| CHEMBL3657851 |  |
IC50 | = | 1.6 | nM | 421.53 | CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F | Homo sapiens | CHEMBL5055691 | cell-based format |
| CHEMBL5094715 |  |
IC50 | = | 1.8 | nM | 543.49 | C[C@@H](c1cc(Cl)cc(Cl)c1)N1CCC(COc2cc(F)c(C(=O)NS(C)(=O)=O)cc2C2CC2)CC1 | Homo sapiens | CHEMBL5055691 | cell-based format |
| CHEMBL5079176 |  |
IC50 | = | 1.8 | nM | 543.49 | C[C@H](c1cc(Cl)cc(Cl)c1)N1CCC(COc2cc(F)c(C(=O)NS(C)(=O)=O)cc2C2CC2)CC1 | Homo sapiens | CHEMBL5055691 | cell-based format |
| CHEMBL3657938 |  |
IC50 | = | 2.2 | nM | 476.61 | O=C(NS(=O)(=O)N1CCCC1)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F | Homo sapiens | CHEMBL5055691 | cell-based format |
| CHEMBL3657939 |  |
IC50 | = | 2.3 | nM | 492.61 | O=C(NS(=O)(=O)N1CCOCC1)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F | Homo sapiens | CHEMBL5055691 | cell-based format |
| CHEMBL5082321 |  |
IC50 | = | 2.4 | nM | 529.46 | CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCN(Cc3cc(Cl)cc(Cl)c3)CC2)cc1F | Homo sapiens | CHEMBL5055691 | cell-based format |
| CHEMBL3945969 |  |
IC50 | = | 3.2 | nM | 543.94 | COc1cc(-c2cc(F)cc(Cl)c2)c(F)cc1-n1c(=O)ccc2cc(S(=O)(=O)Nc3ccon3)ccc21 | Homo sapiens | CHEMBL4321987 | cell-based format |
| CHEMBL5091342 |  |
IC50 | = | 3.6 | nM | 536.67 | CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCN(C(c3ccccc3)c3ccccc3)CC2)cc1F | Homo sapiens | CHEMBL5055691 | cell-based format |
| CHEMBL5082739 |  |
IC50 | = | 4.0 | nM | 463.57 | O=C(NS(=O)(=O)C1COC1)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F | Homo sapiens | CHEMBL5055691 | cell-based format |
| CHEMBL3662226 |  |
IC50 | = | 5.5 | nM | 508.62 | CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CN(C(c3ccccc3)c3ccccc3)C2)cc1F | Homo sapiens | CHEMBL5055691 | cell-based format |
| CHEMBL5071877 |  |
IC50 | = | 7.7 | nM | 544.57 | CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCN(Cc3ccc(OC(F)(F)F)cc3)CC2)cc1F | Homo sapiens | CHEMBL5055691 | cell-based format |
| CHEMBL5080495 |  |
IC50 | = | 9.8 | nM | 543.44 | CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCN(C(=O)c3cc(Cl)cc(Cl)c3)CC2)cc1F | Homo sapiens | CHEMBL5055691 | cell-based format |
| CHEMBL2325014 |  |
IC50 | = | 11.0 | nM | 500.36 | Nc1[nH]ncc1-c1cc(Cl)ccc1Oc1cc(F)c(S(=O)(=O)Nc2cscn2)cc1Cl | Homo sapiens | CHEMBL4321987 | cell-based format |
| CHEMBL4547737 |  |
IC50 | = | 19.0 | nM | 298.3 | CC(=O)OC[C@@H]1NC(=N)N2CCC(O)(O)[C@@]23NC(=N)N[C@@H]13 | Homo sapiens | CHEMBL4321987 | cell-based format |
| CHEMBL5080891 |  |
IC50 | = | 22.0 | nM | 495.02 | CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCN(Cc3ccc(Cl)cc3)CC2)cc1F | Homo sapiens | CHEMBL5055691 | cell-based format |
| CHEMBL507974 |  |
IC50 | = | 36.0 | nM | 319.27 | NC1=N[C@H](O)[C@H]2[C@H]3O[C@]4(O)O[C@@H]([C@@H](O)[C@@]2(N1)[C@@H]4O)[C@]3(O)CO | Homo sapiens | CHEMBL4321987 | cell-based format |