Q01064 | PDE1B_HUMAN | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (PDE1B)

Pfam Domain Table

AccessionDomainRangeColor
PF00233PDEase_I - 3'5'-cyclic nucleotide phosphodiesterase222~449
PF08499PDEase_I_N - 3'5'-cyclic nucleotide phosphodiesterase N-terminal77~137

3D structures mapped by conservation among orthologs

[ Domain: "HD-domain/PDEase-like" // PDEase_I ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL3601563 IC50 = 2.4 nM 339.82 COc1ccc2c([C@H]3CCc4ccc(Cl)cc43)nccc2c1OC Homo sapiens CHEMBL3602928 single protein format
CHEMBL4644729 IC50 = 2.9 nM 453.95 C[C@@H](Nc1nc2c(cnn2C(C)(C)C)c(=O)n1Cc1ccc(F)cc1)c1ccc(Cl)cc1 Homo sapiens CHEMBL4613137 single protein format
CHEMBL4095097 IC50 = 3.0 nM 501.56 COc1ccc(Cn2c(=O)n3ncnc3c3c4c(sc32)CN(CC2CCOCC2)CC4(F)F)cc1 Homo sapiens CHEMBL4011522 single protein format
CHEMBL3601549 IC50 = 4.0 nM 340.81 COc1ccc2c(C3CCc4ccc(Cl)cc43)ncnc2c1OC Homo sapiens CHEMBL3602928 single protein format
CHEMBL4126270 IC50 = 4.5 nM 340.81 COc1ccc2c([C@H]3CCc4ccc(Cl)cc43)ncnc2c1OC Homo sapiens CHEMBL4122466 single protein format
CHEMBL3601550 IC50 = 8.0 nM 385.26 COc1ccc2c(C3CCc4ccc(Br)cc43)ncnc2c1OC Homo sapiens CHEMBL3602928 single protein format
CHEMBL4128481 IC50 = 9.1 nM 327.39 COc1ccc2c(N[C@@H](C)Cc3cc(C)[nH]n3)ncnc2c1OC Homo sapiens CHEMBL4122466 single protein format
CHEMBL4094575 IC50 = 11.0 nM 471.49 COc1ccc(Cn2c(=O)n3ncnc3c3c4c(sc32)CN(C(=O)C2CC2(F)F)CC4)cc1 Homo sapiens CHEMBL4011522 single protein format
CHEMBL4127641 IC50 = 21.0 nM 327.39 COc1ccc2c(NC(C)Cc3cc(C)[nH]n3)ncnc2c1OC Homo sapiens CHEMBL4122466 single protein format
CHEMBL3601548 IC50 = 22.0 nM 328.8 COc1ccc2c(C(C)c3cccc(Cl)c3)ncnc2c1OC Homo sapiens CHEMBL3602928 single protein format
CHEMBL4649493 IC50 = 23.0 nM 447.97 C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)n1Cc1ccccc1)c1ccc(Cl)cc1 Homo sapiens CHEMBL4613137 single protein format
CHEMBL4067682 IC50 = 26.0 nM 483.57 COc1ccc(Cn2c(=O)n3ncnc3c3c4c(sc32)CN(CC2CCOCC2)CC4)c(F)c1 Homo sapiens CHEMBL4011522 single protein format
CHEMBL4102858 IC50 = 27.0 nM 465.58 COc1ccc(Cn2c(=O)n3ncnc3c3c4c(sc32)CN(CC2CCOCC2)CC4)cc1 Homo sapiens CHEMBL4011522 single protein format
CHEMBL4128897 IC50 = 27.0 nM 357.41 COc1cc2c(NC(C)Cc3cc(C)n[nH]3)ncnc2c(OC)c1OC Homo sapiens CHEMBL4122466 single protein format
CHEMBL4078578 IC50 = 31.0 nM 487.99 O=c1n(Cc2ccc(Cl)cc2F)c2sc3c(c2c2ncnn12)CCN(CC1CCOCC1)C3 Homo sapiens CHEMBL4011522 single protein format
CHEMBL3601554 IC50 = 35.0 nM 305.38 CCC(CC)Nc1ncnc2c(OC)c(OC)c(OC)cc12 Homo sapiens CHEMBL4122466 single protein format
CHEMBL512790 IC50 = 38.0 nM 302.76 CC(C)c1n[nH]c2c(=O)[nH]c(Cc3cccc(Cl)c3)nc12 Homo sapiens CHEMBL966925 single protein format
CHEMBL3601551 IC50 = 38.0 nM 324.36 COc1ccc2c(C3CCc4ccc(F)cc43)ncnc2c1OC Homo sapiens CHEMBL3602928 single protein format
CHEMBL4090245 IC50 = 41.0 nM 470.0 O=c1n(Cc2ccc(Cl)cc2)c2sc3c(c2c2ncnn12)CCN(CC1CCOCC1)C3 Homo sapiens CHEMBL4011522 single protein format
CHEMBL431377 IC50 = 48.0 nM 501.63 CN1C(=O)c2c(nc(Cc3ccc(-c4ccccc4)cc3)n2Cc2ccccc2)N2CC3(CCCC3)N=C12 Homo sapiens CHEMBL4011522 single protein format