Q01064 | PDE1B_HUMAN | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (PDE1B)
Pfam Domain Table
Accession | Domain | Range | Color |
---|---|---|---|
PF00233 | PDEase_I - 3'5'-cyclic nucleotide phosphodiesterase | 222~449 | |
PF08499 | PDEase_I_N - 3'5'-cyclic nucleotide phosphodiesterase N-terminal | 77~137 |
3D structures mapped by conservation among orthologs
[ Domain: "HD-domain/PDEase-like" // PDEase_I ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
---|---|---|---|---|---|---|---|---|---|---|
CHEMBL3601563 | IC50 | = | 2.4 | nM | 339.82 | COc1ccc2c([C@H]3CCc4ccc(Cl)cc43)nccc2c1OC | Homo sapiens | CHEMBL3602928 | single protein format | |
CHEMBL4644729 | IC50 | = | 2.9 | nM | 453.95 | C[C@@H](Nc1nc2c(cnn2C(C)(C)C)c(=O)n1Cc1ccc(F)cc1)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4613137 | single protein format | |
CHEMBL4095097 | IC50 | = | 3.0 | nM | 501.56 | COc1ccc(Cn2c(=O)n3ncnc3c3c4c(sc32)CN(CC2CCOCC2)CC4(F)F)cc1 | Homo sapiens | CHEMBL4011522 | single protein format | |
CHEMBL3601549 | IC50 | = | 4.0 | nM | 340.81 | COc1ccc2c(C3CCc4ccc(Cl)cc43)ncnc2c1OC | Homo sapiens | CHEMBL3602928 | single protein format | |
CHEMBL4126270 | IC50 | = | 4.5 | nM | 340.81 | COc1ccc2c([C@H]3CCc4ccc(Cl)cc43)ncnc2c1OC | Homo sapiens | CHEMBL4122466 | single protein format | |
CHEMBL3601550 | IC50 | = | 8.0 | nM | 385.26 | COc1ccc2c(C3CCc4ccc(Br)cc43)ncnc2c1OC | Homo sapiens | CHEMBL3602928 | single protein format | |
CHEMBL4128481 | IC50 | = | 9.1 | nM | 327.39 | COc1ccc2c(N[C@@H](C)Cc3cc(C)[nH]n3)ncnc2c1OC | Homo sapiens | CHEMBL4122466 | single protein format | |
CHEMBL4094575 | IC50 | = | 11.0 | nM | 471.49 | COc1ccc(Cn2c(=O)n3ncnc3c3c4c(sc32)CN(C(=O)C2CC2(F)F)CC4)cc1 | Homo sapiens | CHEMBL4011522 | single protein format | |
CHEMBL4127641 | IC50 | = | 21.0 | nM | 327.39 | COc1ccc2c(NC(C)Cc3cc(C)[nH]n3)ncnc2c1OC | Homo sapiens | CHEMBL4122466 | single protein format | |
CHEMBL3601548 | IC50 | = | 22.0 | nM | 328.8 | COc1ccc2c(C(C)c3cccc(Cl)c3)ncnc2c1OC | Homo sapiens | CHEMBL3602928 | single protein format | |
CHEMBL4649493 | IC50 | = | 23.0 | nM | 447.97 | C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)n1Cc1ccccc1)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4613137 | single protein format | |
CHEMBL4067682 | IC50 | = | 26.0 | nM | 483.57 | COc1ccc(Cn2c(=O)n3ncnc3c3c4c(sc32)CN(CC2CCOCC2)CC4)c(F)c1 | Homo sapiens | CHEMBL4011522 | single protein format | |
CHEMBL4102858 | IC50 | = | 27.0 | nM | 465.58 | COc1ccc(Cn2c(=O)n3ncnc3c3c4c(sc32)CN(CC2CCOCC2)CC4)cc1 | Homo sapiens | CHEMBL4011522 | single protein format | |
CHEMBL4128897 | IC50 | = | 27.0 | nM | 357.41 | COc1cc2c(NC(C)Cc3cc(C)n[nH]3)ncnc2c(OC)c1OC | Homo sapiens | CHEMBL4122466 | single protein format | |
CHEMBL4078578 | IC50 | = | 31.0 | nM | 487.99 | O=c1n(Cc2ccc(Cl)cc2F)c2sc3c(c2c2ncnn12)CCN(CC1CCOCC1)C3 | Homo sapiens | CHEMBL4011522 | single protein format | |
CHEMBL3601554 | IC50 | = | 35.0 | nM | 305.38 | CCC(CC)Nc1ncnc2c(OC)c(OC)c(OC)cc12 | Homo sapiens | CHEMBL4122466 | single protein format | |
CHEMBL512790 | IC50 | = | 38.0 | nM | 302.76 | CC(C)c1n[nH]c2c(=O)[nH]c(Cc3cccc(Cl)c3)nc12 | Homo sapiens | CHEMBL966925 | single protein format | |
CHEMBL3601551 | IC50 | = | 38.0 | nM | 324.36 | COc1ccc2c(C3CCc4ccc(F)cc43)ncnc2c1OC | Homo sapiens | CHEMBL3602928 | single protein format | |
CHEMBL4090245 | IC50 | = | 41.0 | nM | 470.0 | O=c1n(Cc2ccc(Cl)cc2)c2sc3c(c2c2ncnn12)CCN(CC1CCOCC1)C3 | Homo sapiens | CHEMBL4011522 | single protein format | |
CHEMBL431377 | IC50 | = | 48.0 | nM | 501.63 | CN1C(=O)c2c(nc(Cc3ccc(-c4ccccc4)cc3)n2Cc2ccccc2)N2CC3(CCCC3)N=C12 | Homo sapiens | CHEMBL4011522 | single protein format |